Morita Akinori

モリタアキノリ | Morita Akinori

Affiliation and department：
Job title： Assistant Professor
Homepage URL (1)： https://www.tokushima-u.ac.jp/med/health_science/course/iyohoshasen/biomedical-science-technology/

Research field (4)： Environmental effects of chemicals , Environmental effects of radiation , Radiology , Molecular biology

Research keywords (2)： Radiation Biology, Radiation Oncology , Radiation Oncology

Research theme for competitive and other funds (13)：

2021 - 2024 A novel radioprotective mechanism of sodium orthovanadate and its application to radiotherapy
2019 - 2022 Development of radioprotectors that selectively protect normal tissues
2016 - 2018 p53標的創薬による新規放射線防護剤の開発
2012 - 2016 Development of novel kind of radioprotectors that relieve the damage of normal tissues in radiation injury
2009 - 2010 Development of novel kind of p53 inhibitorsthat target the zincbinding site of p53

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Papers (88)：

森田明典, 西山祐一, 坂井卓磨, 東優一. 急性放射線腸管障害の分子機構とその制御. 放射線生物研究. 2023. 58. 2. 93-109
Satoh Hidetoshi, Ochi Shintaroh, Mizuno Kosuke, Saga Yutaka, Ujita Shohei, Toyoda Mihiro, Nishiyama Yuichi, Tada Kasumi, Matsushita Yosuke, Deguchi Yuichi, et al. Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors. Bioorganic & Medicinal Chemistry. 2022. Vol.67. 116764-116764
佐藤秀哉, 越智進太朗, 氏田将平, 豊田美裕, 西山祐一, 多田佳寿美, 松下洋輔, 出口雄一, 鈴木啓司, 田中義正, et al. 放射線防護活性を有する2-Pyrrolone類STK160830の構造活性相関研究. 日本薬学会年会要旨集. 2022. 142年会. 28B-pm01S
Morita Akinori, Ochi Shintaro, Satoh Hidetoshi, Ujita Shohei, Matsushita Yosuke, Tada Kasumi, Toyoda Mihiro, Nishiyama Yuichi, Mizuno Kosuke, Deguchi Yuichi, et al. A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis. Life. 2021. Vol.11. No.10
Nishiyama Yuichi, Morita Akinori, Tatsuta Shogo, Kanamaru Misaki, Sakaue Masahiro, Ueda Kenta, Shono Manami, Fujita Rie, Wang Bing, Hosoi Yoshio, et al. Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome. Genes. 2021. Vol.12. No.10. 1514-1514

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MISC (38)：

Morita Akinori, Nishiyama Yuichi, Sakai Takuma, Higashi Yuichi. Molecular Mechanisms of Acute Radiation Intestinal Injury and Its Control. Radiation Environment and Medicine. 2024. Vol.13. No.1. 10-18
森田明典, 西山祐一, 坂井卓磨, 東優一. Molecular mechanisms of acute radiation intestinal injury and its control. 放射線生物研究. 2023. 58. 2
森田明典, WANG Bing, 田中薫, 勝部孝則, 村上正弘, 下川卓志, 西山祐一. Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice. 量子科学技術研究開発機構研究報告書(Web). 2022. 26
森田明典, WANG Bing, 田中薫, 勝部孝則, 村上正弘, 下川卓志, 西山祐一, 根井充. Evaluation of cell death regulatory agents for protecting particle beam-irradiated mice. 量子科学技術研究開発機構研究報告書(Web). 2021. 20
東優一, 森田明典, 西山祐一, 村田貴嗣, 酒井杏樹, 金井昭教, 谷本大河, 野口桃代, 坂井卓磨, 中田健也, et al. 免疫調節作用を有する新規化合物はDSS誘導大腸炎からマウスを保護する. 日本生化学会大会(Web). 2021. 94th

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Books (3)：

医用放射線辞典第6版執筆者(放射線生物学)
KYORITSU SHUPPAN.CO.,LTD 2023
Fundamentals of Radiological Technology, Radiation Biology
KYORITSU SHUPPAN.CO.,LTD 2020
Radiation biology to learn from mechanism of the human body
MEDICAL VIEW CO., LTD. 2017

Lectures and oral presentations (109)：

日本放射線腫瘍学会第14回放射線生物学セミナー「がん微小環境と放射線治療」 ~放射線細胞死の多様性とその制御~
(日本放射線腫瘍学会第14回放射線生物学セミナー 2024)
急性放射線誘発消化管症候群の分子機構とその制御
(第24回菅原・大西記念癌治療増感シンポジウム 2024)
Protective effect of sodium orthovanadate against radiation-induced male infertility in mice
(The 8th International Symposium of the Network-type Joint Usage/ Research Center for Radiation Disaster Medical Science 2024)
Sodium orthovanadate protects male fertility against radiation exposure
(日本放射線影響学会第66回大会 2023)
Rectal epithelial stem cell kinetics in acute radiation enteritis
(日本放射線影響学会第66回大会 2023)

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Education (1)：

1996 - 2001 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry

Professional career (1)：

Work history (8)：

2015/04 - 現在 Tokushima University Graduate School of Biomedical Sciences Professor
2013/06 - 2015/03 The University of Tokushima Graduate School Institute of Health Biosciences Associate Professor
2011/04 - 2013/05 Hiroshima University Research Institute for Radiation Biology and Medicine Assistant Professor
2007/04 - 2011/03 Faculty of Science and Technology, Tokyo University of Science Assistant Professor
2006/04 - 2007/03 Faculty of Science and Technology, Tokyo University of Science Associate

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Committee career (3)：

Awards (5)：

2018/02/02 - American Association for Cancer Research Molecular Cancer Therapeutics, "Refining Radiation for the Next Century," Focus selection A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist
2015/03 - 公益財団法人放射線影響協会平成26年度放射線影響研究奨励賞 p53を標的とする新規放射線防護剤の開発
2015/02/23 - School of Health Sciences 保健学科教育賞保健学科教育賞
2010/10/21 - Japan Radiation Research Society 日本放射線影響学会第53回大会奨励賞放射線誘発アポトーシスの分子機構とそれを利用した防護剤に関する研究
2007/11/17 - Japan Radiation Research Society 日本放射線影響学会第50回大会優秀発表賞オルトバナジン酸ナトリウムによるp53制御メカニズムの解明

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