Sugihara Kazumi

Research field (1)： Pharmaceuticals - health and biochemistry

Research theme for competitive and other funds (30)：

2019 - 2023 Control of uric acid by considering the change xanthine oxidase activity with the circadian rhythm
2017 - 2020 Epigenetic regulation of sex-specific gene expression and investigation of the effects of environmental chemicals and drugs
2016 - 2019 Influence of chemicals used in consumer products on endocrine-system via activation of nuclear receptors
2016 - 2019 Appropriate administration of nicotine according to the metabolic enzyme activity estimated from the nicotine metabolites in saliva.
2014 - 2017 Investigation of the Pharmaceutical pollution in the pharmacy and the health impact assessment of occupational exposure

2013 - 2016 Estimation for the adequate dose of nicotine by using the ratio of the metabolites in urine

2013 - 2016 Estimation of target proteins of hydroxylated PCB and brominated flame retardants for thyroid hormone disruption and the influence by radiation

2011 - 2014 Risk assessment of chemicals using chimeric mice with humanized liver

2011 - 2012 Determination of targets for thyroid hormone disruption by brominated flame retardants

2009 - 2011 Study of PPCPs in Eastern Asian countries

2008 - 2010 Study of environmental pollution by pharmaceuticals and effect of environmental factors on the toxicity.

2008 - 2010 Effects of neonatal exposure to thyroid hormone disrupting chemicals in rats

2008 - 2010 Drug development using novel animal model based on the pathogenesis of Parkinson' s disease-related disorders

2008 - 2010 Pathogenetic mechanism of sporadic Parkinson's disease based on familial Parkinson's disease

2006 - 2007 Formation of Hydroxylated Metabolites Responsible for the Toxicity of Brominated Flame Retardants and Thyroid Hormone Disrupting Action

2006 - 2007 Integrated analysis of environmental and genetic factors against Caribbean parkinsonism

2006 - 2007 Development of anti-Parkinson's disease drugs using P-glycoprotein knockout mice heated with endogenous neurotoxin.

2005 - 2006 Pharmaceuticals in hospital sewages and their toxicities to ecosystem

2004 - 2005 Thyroid hormone-disrupting activity of brominated retardants and hydroxylated PCBs

2004 - 2005 Parkinsonism-inducing mechanism by endogenous multifunctional neurotoxins in the brain

2002 - 2003 Development of anti-parkinsonian drug using structure-activity relationship

2001 - 2003 内分泌攪乱物質並びにその前駆物質の代謝変換とホルモン作用の修飾

2001 - 2002 Effect of Dioxin and Endocrine disrupters on Adrenal Hormone

2001 - 2002 Metabolic activation of endocrine-disruptors in animal body

2000 - 2001 Research for the Parkinson's disease related proteins using endogenous neurotoxins

1999 - 2000 Metabolism and endocrine disrupting action of environmental pollutants

1998 - 1999 Early markers of Parkinson's disease

1998 - 1999 Investigation of Parkinson's disease causing substances

薬物の代謝及び活性化に関する研究

Drug metabolism and activation

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Papers (53)：

Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta. Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats. Journal of pharmaceutical health care and sciences. 2022. 8. 1. 31-31
Hiroyuki Kojima, Shinji Takeuchi, Seigo Sanoh, Katsuhiro Okuda, Shigeyuki Kitamura, Naoto Uramaru, Kazumi Sugihara, Kouichi Yoshinari. Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology. 2019. 413. 48-55
Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, et al. Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions. Biochemical Pharmacology. 2018. 154. 28-38
Junpei Mori, Seigo Sanoh, Keiko Kashiwagi, Hideki Hanada, Mitsuki Shigeta, Ken-ichi T. Suzuki, Takashi Yamamoto, Yaichiro Kotake, Kazumi Sugihara, Shigeyuki Kitamura, et al. Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis. JOURNAL OF TOXICOLOGICAL SCIENCES. 2017. 42. 5. 605-613
Hitomi Ozaki, Kazumi Sugihara, Yoko Watanabe, Kyoko Moriguchi, Naoto Uramaru, Tomomichi Sone, Shigeru Ohta, Shigeyuki Kitamura. Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues. FOOD AND CHEMICAL TOXICOLOGY. 2017. 100. 217-224

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MISC (22)：

Seigo Sanoh, Naoki Takaoka, Katsuhiro Okuda, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta. INHIBITORY EFFECTS OF DRUGS ON THE METABOLIC ACTIVITIES OF MOUSE AND HUMAN ALDEHYDE OXIDASE ISOFORMS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S83-S83
Seigo Sanoh, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Shigeru Ohta. Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy. DRUG METABOLISM AND PHARMACOKINETICS. 2015. 30. 1. 52-63
Seigo Sanoh, Mami Fujimoto, Yoichi Naritomi, Koya Sato, Akio Kawamura, Aya Horiguchi, Kazumi Sugihara, Shigeyuki Kitamura, Toru Horie, Chise Tateno, et al. PREDICTABILITY OF PLASMA CONCENTRATION-TIME PROFILES IN HUMANS USING CHIMERIC MICE WITH HUMANIZED LIVER. DRUG METABOLISM REVIEWS. 2014. 45. 60-60
Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Chise Tateno, Toru Horie, Shigeyuki Kitamura, Shigeru Ohta. Prediction of PK parameters of human using human chimeric mice. DRUG METABOLISM REVIEWS. 2011. 43. 50-50
Kazumi Sugihara, Hanaka Sako, Miyuki Arai, Seigo Sanoh, Shigeyuki Kitamura, Shigeru Ohta. Effect of Diet on Developmental Changes of Cytochrome P450 in Rat and Mouse. DRUG METABOLISM REVIEWS. 2010. 42. 134-134

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