Rchr
J-GLOBAL ID:200901079724392060
Update date: Oct. 03, 2024
Takahashi Akiko
Takahashi Akiko | Takahashi Akiko
Affiliation and department:
Job title:
Chief
Research field (3):
Tumor biology
, Oral medicine (pathology)
, Molecular biology
Research keywords (5):
Epigenetics
, SASP
, Exosome
, 分子生物学
, Molecular Biology
Research theme for competitive and other funds (9):
- 2022 - 2025 染色体構造異常によるがんの悪性化機構の解析
- 2021 - 2023 自己DNAを標的としたSASP制御への挑戦
- 2019 - 2022 Functional Analysis of Cytoplasmic Nucleic Acid Sensor in the Tumor Microenvironment
- 2019 - 2021 Challenge for elucidation of cross talk between cellular senescence and cell competition
- 2017 - 2019 老化細胞分泌因子による細胞競合制御機構の解明
- 2017 - 2019 Molecular mechanism of genomic DNA fragmentation and secretion
- 2016 - 2019 Elucidation of transformation mechanism from benign tumor to cancer
- 2013 - 2016 Analysis of tumor promotion factors secreted from senescent cells
- Cellular senescence
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Papers (55):
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Hisamichi Tanaka, Sho Sugawara, Yoko Tanaka, Tze Mun Loo, Ryo Tachibana, Atsuki Abe, Mako Kamiya, Yasuteru Urano, Akiko Takahashi. Dipeptidylpeptidase-4-targeted activatable fluorescent probes visualize senescent cells. Cancer Science. 2024
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Kyosuke Yanagawa, Akiko Kuma, Maho Hamasaki, Shunbun Kita, Tadashi Yamamuro, Kohei Nishino, Shuhei Nakamura, Hiroko Omori, Tatsuya Kaminishi, Satoshi Oikawa, et al. The Rubicon-WIPI axis regulates exosome biogenesis during aging. Nature cell biology. 2024
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Hikaru Okawa, Yoko Tanaka, Akiko Takahashi. Network of extracellular vesicles surrounding senescent cells. Archives of Biochemistry and Biophysics. 2024. 754. 109953-109953
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Masatomo Chiba, Kenichi Miyata, Hikaru Okawa, Yoko Tanaka, Koji Ueda, Hiroyuki Seimiya, Akiko Takahashi. YBX1 Regulates Satellite II RNA Loading into Small Extracellular Vesicles and Promotes the Senescent Phenotype. International Journal of Molecular Sciences. 2023. 24. 22. 16399-16399
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Kenichi Miyata, Xiangyu Zhou, Mika Nishio, Aki Hanyu, Masatomo Chiba, Hiroko Kawasaki, Tomo Osako, Kengo Takeuchi, Shinji Ohno, Takayuki Ueno, et al. Chromatin conformational changes at human satellite II contribute to the senescence phenotype in the tumor microenvironment. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 32. e2305046120
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MISC (61):
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千葉 正智, 三澤 知香, 田中 陽子, 高橋 暁子. 【EVs 細胞外小胞の生物学 エクソソームをはじめとする多様な小胞の生理・病理の理解と新しい解析法】(第1章)細胞外小胞の形成と伝播のメカニズム 細胞老化と細胞外小胞. 実験医学. 2021. 39. 20. 3148-3153
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高橋 暁子, 原 英二. いま知りたい!!cGAS-STING経路がいま熱い!明かされる多彩な生命現象への関与と高まる治療標的としての期待 cGAS-STING経路は細胞老化による炎症反応を誘発する. 実験医学. 2021. 39. 9. 1391-1394
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荒谷紗絵, 田中陽子, 酒井直行, 高橋暁子. 老化細胞が分泌する細胞外小胞と腎臓における細胞外小胞の機能. 2020. 12. 233-239
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菅原 祥, 宮田憲一, 田中久道, 高橋暁子. 老化研究と細胞老化の基礎. バイオマテリアル学会誌. 2020. 38. 160-165
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高橋暁子, 宮田憲一, 羅智文, 菅原祥. The Analysis of Epigenetic alteration in cellular senescence and cancer. 日本癌学会学術総会抄録集(Web). 2020. 79th
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Books (4):
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がん分子標的治療研究 実践マニュアル
金芳堂 2009
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Degradayion factors of Dental Polycarbonate
2001
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Degradation Factors of Dental Polycarbonates
"Caries Preventive Restoration" Forum in Sapporo '99 2001
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Long-term Durability of Resin-dentin Bonds
Modern Trands in Adhesive Dentistry Proceedings of the Adhesive Dentistry Forum'99 in tsurumi 1999
Education (3):
- - 2003 Hokkaido University Graduate School of Dental Medicine
- - 1999 Hokkaido University School of Dental Medicine
- - 1999 Hokkaido University Faculty of Dentistry
Professional career (2):
Work history (2):
- 2022/10 - 現在 Japanese Foundation for Cancer Research Division of Cellular Senescence, Cancer Institute Chief
- 2017/04 - 2022/09 Japanese Foundation for Cancer Research Project for Cellular Senescence, Cancer Institute Project Leader
Awards (4):
- 2014/09 - SYMPHONY 優秀ポスター賞
- 2012/09 - 日本癌学会 日本癌学会奨励賞
- 2008/02 - 口腔医科学フロンティア 奨励賞
- 2004/04 - 北海道歯学会 北海道歯学会賞
Association Membership(s) (7):
日本生化学会
, International Society for Extracellular Vesicles
, International Cellular Senescence Association
, 歯科保存学会
, 日本病理学会
, 日本分子生物学会
, 日本癌学会
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