Rchr

J-GLOBAL ID：200901079927976106 Update date: Sep. 20, 2024

Matsumoto Sohkichi

マツモトソウキチ | Matsumoto Sohkichi

Affiliation and department：
Job title： Professor
Other affiliations (2)：

Faculty of Medicine, Airlangga University Adjacent Professor
大阪市立大学大学院医学研究科客員教授

Homepage URL (2)： http://www.med-niigatauniv-bacteriol.org , http://www.med.niigata-u.ac.jp/eng/research/kiso/saikin.html

Research field (2)： Bacteriology , Immunology

Research keywords (10)： persister , tuberculosis , dormancy and latent infection , Bacteria , mycobacteria , Drug development against mycobacterial diseases , Host immunity and Vaccine Development against tuberculosis , Development of diagnosis of mycobacterial diseases , Infectious diseases , Mycobacterium

Research theme for competitive and other funds (33)：

2021 - 2025 International joint research aimed at developing new diagnostic and control methods for tuberculosis
2020 - 2024 天然変性ヒストン様蛋白質による、結核菌の個性の創出と多様性獲得の分子機構
2020 - 2023 Analysis of molecular mechanism of mitochondrial damage and immune suppression induced by Mycobacterium tuberculosis
2016 - 2019 Study of tuberculosis latency and development of anti-tuberculosis strategy by keeping latent state
2016 - 2019 A new treatment for postoperative intractable inflammatory condition focusing on antibacterial effect and intestinal regulation of yogurt

2015 - 2018 Study of the protective immune mechanism against tuberculosis through pDC activation induced by CpG-ODN and Mycobacterium tuberculosis antigen

2015 - 2018 Investigation of genomic characters specific for high-virulence multidrug-resistant Mycobacterium tuberculosis

2014 - 2018 The research in Kenya for the development a diagnostic method of asymptomatic M tuberculosis infection and disease progression

2013 - 2016 Possibility of epigenetic regulation in bacteria through the post-translational modification of a histone-like protein

2013 - 2016 Biofilm formation mechanism by intercellular signaling molecule of environmental pathogen

2012 - 2016 The motion of novel strategy against tuberculosis based on the analysis of latent tuberculosis

2012 - 2015 Research for genetic specificity of the Multi Drug-resistant Mycobacterium tuberculosis Spreading in Osaka Prefecture.

2011 - 2014 Research in Kenya for the development of diagnosis of latent and active tuberculosis

2009 - 2011 Molecular mechanism of drug tolerance in dormant mycobacteria and identification of the drug target

2009 - 2010 潜在性結核対策を想定した、抗酸菌の長期生存を可能にする分子メカニズムの解明

2007 - 2008 Ribosome-binding dependent induction of translational suppression and acquiring drug resistance caused by M. tuberculosis protein, MDP1

2006 - 2007 結核菌の休眠誘導と潜伏感染成立/回避の分子機構

2004 - 2006 The molecular mechanism of host responses against cell wall components of mycobacteria

2005 - 2005 結核菌のヒストン様蛋白質MDP1による菌の休眼誘導と潜伏感染成立/回避の分子機構

2002 - 2003 結核菌の新規蛋白質MDP1による,菌の増殖抑制及び休眠状態誘導の機構解析

2002 - 2002 抗酸菌感染における気道上皮細胞応答の分子機構

2002 - 2002 SERA高分泌型、組み換えBCG菌の作製及び免疫原性の検討

2001 - 2001 ヒトマラリアの防御抗原を発現する組み換えBCGワクチンの作製

1997 - 2000 A study for non-specific or specific immunochemotherapy by using recombinant BCG

1999 - 1999 組み換えBCGワクチンシステムを用いた、う蝕予防ワクチンの開発

1999 - 1999 SERAを発現する組み換えBCGワクチンの作製及び防御効果の検討

1998 - 1998 マラリアのワクチン開発を目指した,BCGからのSERA抗原発現の試み

1996 - 1996 歯周病関連菌由来,ストレス蛋白質の免疫学的研究

1995 - 1995 A.actinomycetecomcomitansの熱ショック蛋白質の研究

1994 - 1994 A.actinomycetemcomitansの熱ショック蛋白質の研究

Development of malaria vaccine

Study of artigenic proteins of the microbiol of periodontal disease

Study of antigenic proteins of mycobacteria

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Papers (133)：

Yuriko Ozeki, Akira Yokoyama, Akihito Nishiyama, Yutaka Yoshida, Yukiko Ohara, Tsukasa Mashima, Chikako Tomiyama, Amina K Shaban, Atsuki Takeishi, Mayuko Osada-Oka, et al. Recombinant mycobacterial DNA-binding protein 1 with post-translational modifications boosts IFN-gamma production from BCG-vaccinated individuals' blood cells in combination with CpG-DNA. Scientific reports. 2024. 14. 1. 9141-9141
Ikkoh Yasuda, Naomi Ruth D. Saludar, Ana Ria Sayo, Shuichi Suzuki, Akira Yokoyama, Yuriko Ozeki, Haruka Kobayashi, Akihito Nishiyama, Sohkichi Matsumoto, Sharon E. Cox, et al. Evaluation of cytokine profiles related to Mycobacterium tuberculosis latent antigens using a whole-blood assay in the Philippines. Frontiers in Immunology. 2024. 15
Atsuki Takeishi, Amina K. Shaban, Taichi Kakihana, Hayato Takihara, Shujiro Okuda, Hidekazu Osada, Desak Nyoman Surya Suameitria Dewi, Yuriko Ozeki, Yutaka Yoshida, Akihito Nishiyama, et al. Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo. Microbiology and Immunology. 2024
Madoka Kishino, Azumi Hida, Evans A Chadeka, Manabu Inoue, Mayuko Osada-Oka, Sohkichi Matsumoto, Sammy M Njenga, Shinjiro Hamano, Sachiyo Nagi. Association between diet quality and risk of stunting among school-aged children in Schistosoma mansoni endemic area of western Kenya: a cross-sectional study. Tropical medicine and health. 2024. 52. 1. 12-12
Akihito Nishiyama, Masahiro Shimizu, Tomoyuki Narita, Noriyuki Kodera, Yuriko Ozeki, Akira Yokoyama, Kouta Mayanagi, Takehiro Yamaguchi, Mariko Hakamata, Amina Kaboso Shaban, et al. Dynamic action of an intrinsically disordered protein in DNA compaction that induces mycobacterial dormancy. Nucleic acids research. 2023

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MISC (263)：

山崎智也, 石川智史, 田村敏生, 塚本裕美子, Nyoman Desak, 吉田豊, 尾関百合子, 西山晃史, 立石善隆, 松本壮吉. 野生型結核菌抗原を用いた抗体検出による活動性結核の診断と発症予測法の検討. 日本細菌学雑誌. 2023. 78. 1. 69-69
阿部透, 若松のぞみ, 西山晃史, 立石善隆, 松本壮吉, 上田大次郎, 佐藤努. Identification of a new type of enzyme that reduces E- and Z-isoprene units. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
阿部透, 袴田真理子, 西山晃史, 立石善隆, 松本壮吉, 邊見久, 上田大次郎, 佐藤努. Functional analysis of a new type of Z, E-mixed prenyl reductase from mycobacteria. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
阿部透, 若松のぞみ, 西山晃史, 立石善隆, 松本壮吉, 上田大次郎, 佐藤努. E-及びZ-イソプレンユニットを還元する新しいタイプの酵素の同定. イソプレノイド研究会例会講演要旨集. 2022. 32nd
瀧井猛将, 瀧井猛将, 安田直美, 長谷川倫宏, 黒石隆司, 堀田康弘, 堀田康弘, 伊藤佐生智, 前田伸司, 和田崇之, et al. 抗結核化合物OCT313と類縁化合物の休眠期結核菌に対する抗菌活性の検討. 微生物シンポジウム講演要旨集. 2021. 33rd

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Patents (5)：

免疫原性を有するMDP1の製造方法
免疫刺激G9.1の抗結核ブースターワクチン創出への応用
遅発育性抗酸菌ポリペプチド
MDP1を用いた炭水化物を有する物質の分離方法
MDP1による微生物を凝集および/または沈殿させる方法

Books (12)：

バイオフィルム革新的制御技術
エヌ・ティー・エス 2023 ISBN:9784860438340
BCG : TB vaccine : application against tuberculosis and other diseases
Japan Anti-Tuberculosis Association 2022 ISBN:9784874513224
創薬研究者がこれだけは知っておきたい最新のウイルス学
技術情報協会 2021 ISBN:9784861048555
Microbiology
2021 ISBN:9784260043311
シンプル微生物学
南江堂 2018

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Lectures and oral presentations (36)：

Development of control strategies against tuberculosis based on molecular mechanisms of persistence of tuberculosis and host immune response to it (Abstract book P8).
(The 1st International Scientific Meeting on Clinical Microbiology and Infectious Diseases (ISM-CMID). 10th National Congress of Indonesian Society for Clinical Microbiology (KONAS-PAMKI), 12th National Symposium-Indonesian Antimicrobial Resistance Watch ( 2018)
From biology of Mycobacterium to the development of the control strategies against tuberculosis,
(The 13th Nagasaki-Singapore Medical Symposium 2017)
抗酸菌の「長生き」のメカニズムと結核対策への応用
(第92回日本結核病学会総会 2017)
Diagnosis of TB infections.
(6th Conference of International Union Against Tuberculosis and Lung Disease, Asia Pacific Region 2017)
結核・抗酸菌に特徴的な薬剤標的と新規薬剤の開発研究
(65回日本感染症学会東日本地方会 2016)

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Education (1)：

1986 - 1992 Nagasaki University Faculty of Dentistry

Professional career (2)：

Doctor (Medicine) (Nagasaki University)
Doctor (Dentistry) (Nagasaki University)

Work history (9)：

2023/04 - 現在 Hokkaido University
2018/10 - 現在 Airlangga University Adjunct Professor
2014/04 - 現在大阪市立大学大学院医学研究科客員教授
2013/09 - 現在 Niigata University School of Medicine, Faculty of Medicine
2007/04 - 2013/08 Osaka City University med, Medical School

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Committee career (5)：

2023/04 - 現在 Mycobacterial Diseases panel, US-Japan Cooperative Medical Science Program Chair
2016/07 - 現在 Member
2014/04 - 現在日本バイオフィルム学会理事
2009 - 現在日本細菌学会評議員
2012/04 - 2023/03 U.S.-Japan Cooperative Medical Sciences Program, Tuberculosis & Leprosy Panel

Awards (1)：

2011 - 日本細菌学会小林六造記念賞結核菌の病原性および増殖制御機構の分子遺伝学的解析と応用研究

Association Membership(s) (4)：

JAPANESE SOCIETY FOR BACTERIOLOGY , THE JAPANESE SOCIETY FOR BIOFILM RESEARCH , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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