Kakehashi Anna

Research field (1)： Experimental pathology

Research keywords (10)： NAFLD/NASH , Oxidative stress-DNA damage-DNA repair , Cancer Risk Assessment , Translational Research , Cancer Prevention , 機能生物化学 , 分子生物学 , 毒性病理学 , Molecular Pathology , Chemical Carcinogenesis

Research theme for competitive and other funds (16)：

2017 - 2020 Investigation of markers and mechanisms of NASH-associated liver cancer
2016 - Novel biomarkers and mechanisms in NASH-related hepatocarcinogenesis
2012 - 2015 Pinpoint targeting of hepatocellular carcinoma for new therapeutic application
2012 - 2015 Pinpoint targeting of hepatocellular carcinoma for new therapeutic application
2012 - 2013 ラットにおける2-エトキシ-2-メチルプロパンの肝臓発がん性のメカニズム解析試験-透過電子顕微鏡解析

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Papers (185)：

Shugo Suzuki, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi. Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway. Toxicology letters. 2023. 384. 128-135
Yuka Yokota, Shugo Suzuki, Min Gi, Yukie Yanagiba, Nao Yoneda, Masaki Fujioka, Anna Kakehashi, Shigeki Koda, Hiroshi Suemizu, Hideki Wanibuchi. o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice. Toxicology. 2023. 488. 153483-153483
Taisuke Matsue, Min Gi, Masayuki Shiota, Hirokazu Tachibana, Shugo Suzuki, Masaki Fujioka, Anna Kakehashi, Tomoki Yamamoto, Minoru Kato, Junji Uchida, et al. The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β-catenin signaling. Cancer science. 2022. 113. 8. 2642-2653
Anna Kakehashi, Shugo Suzuki, Masayuki Shiota, Nina Raymo, Min Gi, Taro Tachibana, Vasily Stefanov, Hideki Wanibuchi. Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis. Cancers. 2021. 13. 14
Anna Kakehashi, Arpamas Chariyakornkul, Shugo Suzuki, Napaporn Khuanphram, Kumiko Tatsumi, Shotaro Yamano, Masaki Fujioka, Min Gi, Rawiwan Wongpoomchai, Hideki Wanibuchi. Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis. Cancers. 2021. 13. 6

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MISC (165)：

魏民, 藤岡正喜, 梯アンナ, 奥野高裕, 増村健一, 能美健彦, 松本道治, 大森雅子, 鰐渕英機, 福島昭治. 1,4-ジオキサンはin vivo変異原性陽性であるその変異原性および発がん性の定量解析. 大阪市医学会雑誌. 2020. 69. 32-32
梯アンナ, 鈴木周五, 魏民, 鰐渕英機. NASH肝発がんにおける特異的候補分子および新規マーカーとしてCACHD1の役割. 日本癌学会総会記事. 2020. 79回. PE1-6
魏民, 行松直, 鈴木周五, 梯アンナ, 鰐渕英機. ラットにおけるacetoaceto-o-toluidideの膀胱発がん促進作用. The Journal of Toxicological Sciences. 2020. 45. Suppl. S159-S159
梯アンナ, 石井直美, 魏民, 鈴木周五, 鰐渕英機. NASH肝臓発がんにおける新規マーカー候補分子の検討. 日本毒性病理学会講演要旨集. 2020. 36回. 79-79
魏民, 鈴木周五, 梯アンナ, 山口貴嗣, 鰐渕英機. ジフェニルアルシン酸のマウスにおける経胎盤発がん作用. 日本毒性病理学会講演要旨集. 2020. 36回. 82-82

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Books (3)：

遺伝毒性発がん物質の低用量の発がんリスク評価
Chapter 1, In book: Thresholds of Genotoxic Carcinogens, Dec 2016, Pages 1-17, DOI10.1016/B978-0-12-801663-3.00001-7 2016
Isoleucine, Leucine and Their Role in Experimental Models of Bladder Carcinogenesis. In: Branched Chain Amino Acids in Clinical Nutrition
In: Branched Chain Amino Acids in Clinical Nutrition, Springer New York, pp. 253-260, 2015 2015
Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies
In: Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification, Chapter 8. Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies. Editors: Hsu C.-H. and Stedeford T. John Wiley & Sons, Inc., Hoboken, NJ, USA, 832 pages, pp. 207-222, 2010. 2010

Lectures and oral presentations (154)：

ラットにおけるBBN誘発膀胱発がんに対するo-Acetoacetotoluidideの促進効果
(第36回日本毒性病理学会総会及び学術集会 2020)
ジフェニルアルシン酸のマウスにおける経胎盤発がん作用
(第36回日本毒性病理学会総会及び学術集会 2020)
NASH肝臓発がんにおける新規マーカー候補分子の検討
(第36回日本毒性病理学会総会及び学術集会 2020)
ジフェニルアルシン酸の長期毒性及びその発現機序-動物試験から得られた知見-
(第23回ヒ素シンポジウム 2019)
非アルコール性脂肪肝炎の肝臓癌におけるアルギニン及び糖代謝産物の蓄積
(第78回日本癌学会学術総会 2019)

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Works (3)：

Proteomics in resolving mechanisms of hepatocarcinogenesis
2005 -
Carcinogenicity mechanisms of phenobarbital and organic arsenicals (DMA, MMA and TMAO)
1999 - 2003
Hormesis in carcinogenicity of non-genotoxic carcinogens
2000 -

Education (1)：

- 2003 Osaka City University Graduate School, Division of Medicine Chemical carcinogenesis Cancer risk assessment Mol.pathology

Professional career (1)：

Ph.D., D.M.Sc. (Osaka Metropolitan University)

Work history (5)：

2006/07/01 - 現在 Osaka City University Graduate School of Medicine Basic Medicine Course Lecturer
2011/09 - 2019/04 Osaka City University Graduate School of Medicine,Dept. Molecular Pathology Lecturer
2006 - Osaka City University, First Department of Pathology
2006 - Osaka City University
2006 - 大阪市立大学医学研究科堵市環境病理

Committee career (2)：

2020/02 - 2025 Cancers, The Journal of The Irish Association for Cancer Research (IACR) and Signal Transduction Society (STS) Paper (Topic) Editor
2020/02 - 2025 Cancers 、アイルランド癌学会論文トピック編集委員

Awards (11)：

2018/03/15 - Osaka City Medical Association President Award 2017 Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers
2018/03/15 - Dean Award of Excellence 2017 Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Journal: Oxidative Medicine and Cellular Longevity
2018/03/15 - Japan Osaka City Medical Association President Award 2017 Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital
2013/03/15 - Young Researcher Award & Traveler's Grant YT-4-1(YRA)
2013/03/15 - Osaka City Medical Association President Award 2012 2-Amino-3-methylimidazo(4,5-f)Quinoline (IQ) Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-beta and Wnt/beta-catenin Signaling Pathways

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Association Membership(s) (8)：

Japanese Association for Cancer Prevention , Japanese Toxicology Association , Japanese Toxicologic Pathology Association , Japanese Pathology Association , Japanese Association for Cancer Research , Society of Toxicology (USA) , Japanese Food and Chemical Association , Japanese Society for Carcinogenic Pathology

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