Kakehashi Anna

• 2023 - 2025 Identification of early detection diagnostic markers for invasive pancreatic ductal carcinoma and development of a new organoid culture model
• 2021 - 2023 Identification of novel biomarkers and molecular targets for early detection and treatment of invasive pancreatic ductal carcinoma
• 2017 - 2020 Investigation of markers and mechanisms of NASH-associated liver cancer
• 2016 - Novel biomarkers and mechanisms in NASH-related hepatocarcinogenesis
• 2012 - 2015 Pinpoint targeting of hepatocellular carcinoma for new therapeutic application
2012 - 2015 Pinpoint targeting of hepatocellular carcinoma for new therapeutic application
2012 - 2013 ラットにおける2-エトキシ-2-メチルプロパンの肝臓発がん性のメカニズム解析試験-透過電子顕微鏡解析
2011 - 2013 Proteomics of Human Pancreatic Ductal Adenocarcinoma using FFPE Sections
2010 - 2013 Proteome analysis of isolated glomeruli of diabetic nephropathy
2011 - 2012 ラットにおける2-エトキシ-2-メチルプロパンの肝臓発がん性のメカニズム解析試験における分子生物学的検索
2010 - 2012 The strategic proteome analysis for the development of early diagnosis and therapeutic target of primary lung adenocarcinoma
2008 - 2009 ナノマテリアルのヒト健康影響の評価手法に関する総合研究
2007 - 2008 Investigation of hepatocarcinogenesis mechanisms : targeted proteomics of liver preneoplastic lesions and tumors
2003 - がんの化学予防
2003 - 発がんの機序解明:生化学及び分子生物学的解析
2002 - Hormesis in rat hepatocarcinogenesis
1999 - 環境化学物質の発がんリスク評価
ヒ素発がん機序解明

• Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota, et al. Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells. Archives of toxicology. 2024. 98. 7. 2065-2084
• Shugo Suzuki, Min Gi, Masami Komiya, Asuka Obikane, Arpamas Vachiraarunwong, Masaki Fujioka, Anna Kakehashi, Yukari Totsuka, Hideki Wanibuchi. Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis. Biomolecules. 2023
• Tomoki Yamamoto, Min Gi, Satoshi Yamashita, Shugo Suzuki, Masaki Fujioka, Arpamas Vachiraarunwong, Runjie Guo, Guiyu Qiu, Anna Kakehashi, Minoru Kato, et al. DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis. Cancers. 2023. 15. 21
• Shugo Suzuki, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi. Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway. Toxicology letters. 2023. 384. 128-135
• Yuka Yokota, Shugo Suzuki, Min Gi, Yukie Yanagiba, Nao Yoneda, Masaki Fujioka, Anna Kakehashi, Shigeki Koda, Hiroshi Suemizu, Hideki Wanibuchi. o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice. Toxicology. 2023. 488. 153483-153483

ｍore...

• 魏 民, 藤岡 正喜, 梯 アンナ, 奥野 高裕, 増村 健一, 能美 健彦, 松本 道治, 大森 雅子, 鰐渕 英機, 福島 昭治. 1,4-ジオキサンはin vivo変異原性陽性である その変異原性および発がん性の定量解析. 大阪市医学会雑誌. 2020. 69. 32-32
• 梯 アンナ, 鈴木 周五, 魏 民, 鰐渕 英機. NASH肝発がんにおける特異的候補分子および新規マーカーとしてCACHD1の役割. 日本癌学会総会記事. 2020. 79回. PE1-6
• 魏 民, 行松 直, 鈴木 周五, 梯 アンナ, 鰐渕 英機. ラットにおけるacetoaceto-o-toluidideの膀胱発がん促進作用. The Journal of Toxicological Sciences. 2020. 45. Suppl. S159-S159
• 梯 アンナ, 石井 直美, 魏 民, 鈴木 周五, 鰐渕 英機. NASH肝臓発がんにおける新規マーカー候補分子の検討. 日本毒性病理学会講演要旨集. 2020. 36回. 79-79
• 魏 民, 鈴木 周五, 梯 アンナ, 山口 貴嗣, 鰐渕 英機. ジフェニルアルシン酸のマウスにおける経胎盤発がん作用. 日本毒性病理学会講演要旨集. 2020. 36回. 82-82

ｍore...

• 遺伝毒性発がん物質の低用量の発がんリスク評価
  Chapter 1, In book: Thresholds of Genotoxic Carcinogens, Dec 2016, Pages 1-17, DOI10.1016/B978-0-12-801663-3.00001-7 2016
• Isoleucine, Leucine and Their Role in Experimental Models of Bladder Carcinogenesis. In: Branched Chain Amino Acids in Clinical Nutrition
  In: Branched Chain Amino Acids in Clinical Nutrition, Springer New York, pp. 253-260, 2015 2015
• Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies
  In: Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification, Chapter 8. Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies. Editors: Hsu C.-H. and Stedeford T. John Wiley & Sons, Inc., Hoboken, NJ, USA, 832 pages, pp. 207-222, 2010. 2010

• ラットにおけるBBN誘発膀胱発がんに対するo-Acetoacetotoluidideの促進効果
  (第36回日本毒性病理学会総会及び学術集会 2020)
• ジフェニルアルシン酸のマウスにおける経胎盤発がん作用
  (第36回日本毒性病理学会総会及び学術集会 2020)
• NASH肝臓発がんにおける新規マーカー候補分子の検討
  (第36回日本毒性病理学会総会及び学術集会 2020)
• ジフェニルアルシン酸の長期毒性及びその発現機序-動物試験から得られた知見-
  (第23回ヒ素シンポジウム 2019)
• 非アルコール性脂肪肝炎の肝臓癌におけるアルギニン及び糖代謝産物の蓄積
  (第78回日本癌学会学術総会 2019)

ｍore...

• Proteomics in resolving mechanisms of hepatocarcinogenesis
  2005 -
• Carcinogenicity mechanisms of phenobarbital and organic arsenicals (DMA, MMA and TMAO)
  1999 - 2003
• Hormesis in carcinogenicity of non-genotoxic carcinogens
  2000 -

• - 2003 Osaka City University Graduate School, Division of Medicine Chemical carcinogenesis Cancer risk assessment Mol.pathology

• Ph.D., D.M.Sc. (Osaka Metropolitan University)

• 2023/07 - 現在 Osaka Metropolitan University Graduate School of Medicine Molecular Pathology Associate Professor
• 2013/04 - 2023/06 Osaka City University Graduate School of Medicine,Dept. Molecular Pathology Assistant Professor
• 2006/07 - 2013/03 Osaka City University Graduate School of Medicine Basic Medicine Course Lecturer
• 2006 - Osaka City University, First Department of Pathology
• 2006 - 大阪市立大学医学研究科堵市環境病理

• 2020/02 - 2025 Cancers, The Journal of The Irish Association for Cancer Research (IACR) and Signal Transduction Society (STS) Paper (Topic) Editor
• 2020/02 - 2025 Cancers 、アイルランド癌学会 論文トピック編集委員

• 2018/03/15 - Osaka City Medical Association President Award 2017 Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers
• 2018/03/15 - Dean Award of Excellence 2017 Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Journal: Oxidative Medicine and Cellular Longevity
• 2018/03/15 - Japan Osaka City Medical Association President Award 2017 Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital
• 2013/03/15 - Young Researcher Award & Traveler's Grant YT-4-1(YRA)
• 2013/03/15 - Osaka City Medical Association President Award 2012 2-Amino-3-methylimidazo(4,5-f)Quinoline (IQ) Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-beta and Wnt/beta-catenin Signaling Pathways
2013/01/31 - The 29th Annual Meeting , President Award Possibility of Cancer Initiating Cell of Bronchiolar Alveolar Stem Cell for Mice Lung SCC
2011/01/31 - Japan JTP Best-Paper-of-the-Year Award Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis
2009/01/30 - JTP Scientific Awards 2009 Paper Award Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis
2003/07/20 - Award for young scientists from Society of Toxicology of Japan Carcinogenicity of low doses of phenobarbital in the rat liver: Evidence for hormesis
2002/01/25 - Award from the Chairman of Society of Toxicologic Pathology of Japan
2002 - 第18回日本日本毒性病理学会:会長賞;

Japanese Association for Cancer Prevention ,  Japanese Toxicology Association ,  Japanese Toxicologic Pathology Association ,  Japanese Pathology Association ,  Japanese Association for Cancer Research ,  Society of Toxicology (USA) ,  Japanese Food and Chemical Association ,  Japanese Society for Carcinogenic Pathology