YUTAKA KAWAKAMI | Researcher Information

2023 - 2028 犬腫瘍に対する個別化併用がん免疫療法の開発
2023 - 2026 T細胞の代謝と分化を制御するリソソーム不等分配におけるV-ATPaseの役割
2021 - 2024 免疫チェックポイント阻害剤応答性細胞集団に発現する新規機能分子の解析
2020 - 2023 がん微小環境におけるがん遺伝子と脂質代謝異常による免疫抑制機構の解明とその制御
2019 - 2022 Berberineによる抗腫瘍免疫増強効果の機構解明と効果的な併用免疫療法の開発

2018 - 2021 Evaluation of the role of beta-catenin pathway in human melanoma in anti-cancer immune responses

2018 - 2021 The development of novel molecularly target therapy against melanomas by targeting NUAK2

2018 - 2021 Development of novel combined immunotherapy using in silico screening system

2016 - 2019 Analysis of non-uniform immune-suppressive mechanisms in tumor microenvironment and development of effective anti-tumor immune therapies

2014 - 2019 Investigation of differential immune status among cancer patients and development of personalized cancer therapy by combining immunomodulation

2015 - 2018 Involvement of transcription factor HOXD9 in the malignant phenotype of cervical cancer

2015 - 2018 Immunomodulation of ovarian clear cell carcinoma by targeting HNF-1 beta pathway

2015 - 2018 Identification of the sub-population in human malignant melanoma showing strong resistance to tumor specific cytotoxic T cells

2015 - 2018 Development of a novel molecular targeted therapy against acral melanomas

2015 - 2018 Analysis of molecular biological and tumor immunological characteristics of HPV negative cervical adenocarcinoma

2014 - 2017 Development of novel immunotherapy targeting leukemic stem cells.

2014 - 2016 Effects of cancer-testis antigens on the signaling and biological activity of the malignant melanoma cells

2013 - 2016 Study on roles of aryl hydrocarbon receptor (AhR) in tumor microenvironment and estimation of AhR as a therapeutic target for cancer patients

2013 - 2015 Systematic analysis of cellular signaling involved in the melanoma induced immunosuppression

2012 - 2015 Immunosuppressive roles of HNF-1beta in ovarian clear cell carcinoma (OCCC)

2012 - 2015 Expression and Functional Analysis of HOXD9 in Cervical Cancer

2012 - 2015 Elucidation of the condition of construction mechanisms of immunity on sentinel lymph nodes of patients with melanoma and development of novel immunotherapy

2011 - 2014 Development of effective immunotherapy by combining interventions on key points in the anti-tumor immune network

2011 - 2013 Elucidation of the mechanism of immunosuppression by stromal cells and mesenchymal stem cells in ovarian cancer

2011 - 2013 Functional analysis of CHD family in neural stem cells and glioma stem cells

2011 - 2012 Investigation of roles of miRNA in the immunosuppression and clinical use for patients with melanoma

2010 - 2012 Analysis of mechanisms for immunosuppression through ILT7/NKp44/BDCA2 ligands expressed on cancer cells

2010 - 2012 Metabolic status of sentinel lymph node from gastrointestinal cancer

2009 - 2011 Analysis of immunosuppressive microenvironment associated with Epithelial-Mesenchymal Transition in uterine cancer.

2009 - 2011 Elucidation of the resistance mechanisms of immunotherapy by the abnormal signal transduction in melanoma and development of methods to overcome it

2009 - 2011 Bone-metastatic tumor cells induce systemic immunosuppression through increase of immunoregulatory mesenchymal stem cells

2009 - 2010 iPS細胞・間葉系幹細胞からの色素細胞と悪性黒色腫の作成と発現分子の臨床応用

2008 - 2010 Detection of immunoresponse to flame-shift proteins in MSI positive endometrial cancer patients.

2005 - 2009 Development of immunotherapy based on the identification of tumor antigens

2007 - 2008 Development of diagnostic method and immunotherapy using a novel molecule specifically expressed in colorectal carcinomas

2007 - 2008 Functional analysis of molecules identified by comprehensive geneexpressive analysis for development of diagnosis and treatment ofmelanoma

2007 - 2008 Investigation of the significance of HERV expression in cancer cells for development of effective cancer therapy

2007 - 2008 Development of effective immunotherapy by combining methods to restore immunocompetence of cancer patients

2007 - 2008 Development of new treatment for endometrial cancer based on theanalysis of immune suppressive molecules

2006 - 2007 Role of donorderived fibroblasts in the pathogenic process of lacriimal gland chronic graft-versus-host disease

2006 - 2007 The study of immunosuppressive mechanisms induced by gastrointestinal cancer during epithelial-mesnchymal transition and clinical application of this target therapy

2005 - 2006 悪性黒色腫幹細胞と色素細胞特異的ABCB5の生物学的・臨床的意義の解明

2005 - 2006 Cellular Immunotherapy for Pathological Retinal Neovascularization

2005 - 2006 Functional analysis of candidate antigens identified by DNA microarray for highly expression in melanoma

2002 - 2006 Development of new diagnostic and immunotherapeutic methods for patients with cancer

2004 - 2005 Development of Cancer Gene Therapy against malignant melanoma by using RNA intereference.

2004 - 2005 Identification of novel autoantigens using human IgG in SCID mice implanted with lacrimal and salivary grands from patients with Sjogren's Syndrome

2004 - 2005 Analysis of human tumor immunity using a new model system with endometrial cancer transplanted SCID mice for clinical application

2004 - 2005 Identification of new cervical cancer antigens by SEREX using sera from cervical cancer tissue transplanted SCID mice

2003 - 2005 γ鎖/RAG2ダブルノックアウトマウスを用いた新しい癌特異的免疫反応評価法の確立

2003 - 2005 Development of immuno-monitoring methods and immunotherapy using glioma antigens

2003 - 2004 神経軸索伸展阻害分子を標的としたワクチンによる中枢神経再生の試み

2003 - 2004 Investigation of the function of genes expressed in melanoma/melanocyte with RNA interference for understanding of pigment disorders

2000 - 2004 メラノーマに対する新しい免疫療法の開発

2002 - 2003 Systemic identification of mutated proteins with frame-shifted from MSI positive colon carcinoma

2002 - 2003 Identification of minor histacompatibility antigens associated with graft uersus leukemia effect.

2001 - 2003 Development of novel minimally invasive surgery for solid tumors using sentinel node navigation

2001 - 2002 Identification of glioma specific genes for the molecular marker

2001 - 2002 Using soluble HLA-peptide tetramer, the studies on the cloning and immune-response monitoring of melanoma antigen-specific cytotoxic lymphocyte

2000 - 2002 Identification of antigens specific for brain tumors

2000 - 2002 Analysis of Pathogenic Autoreactive T cells in Patients with Antiphospholipid Syndrome and its Application for Developing Specific Immune Therapies

2001 - 2001 臨床応用可能なウイルスベクター製造のための企画調査

2000 - 2001 Identification of autoantigens in Vogt-Koyanagi-Harada disease using recombinant retrovirus encoding melanocyte-specitic antigen genes

2000 - 2001 IDENTIFICATION OF NEW ANTIGENS IN ENDOMETRIAL CARCINOMA

2000 - 2001 Development of diagnositic and therapeutic methods using frameshift mutated peptides for colorectal cancers with microsatellite instability

2000 - 2001 Systematic isolation of genes encoding candidate proteins for human melanoma antigens using serial analysis of gene expression (SAGE) and EST database

1999 - 2001 Study on transcutaneous immunization using peptides of melanomd entigens with high affinity to MHC

1999 - 2000 Using solubel peptide-MHC tetramer, the trial of staining and cloning the melanoma antigen-specific cytotoxic lymphocytes

1998 - 1999 移植片対宿主病(GVHD)に関わるマイナー組織適合抗原の同定

1998 - 1999 Identification of autoantigens recohnized by auto-react T cells in Vogt-Koyanagi-Harada disease

1998 - 1999 IDENTIFICATION OF NEW ANTIGENS IN RENAL CELL CARCINOMA

1998 - 1999 Development of novel immuno-gene therapy for gastrointestinal cancer using antigen presenting function of heat shock protein

1998 - 1999 Development and Characterization of Desmoglein-3 Specific T cells from Japanese Patients with Pemphigus Vulgaris

1998 - 1999 Identification of new tumor antigens using testis-specific proteins

1998 - 1999 Isolation of human melanoma antigens recognized bt T cells for development of immunotherapy and gene therapy

1998 - 1999 Isolation of human tumor antigens recognized by antibodies for development of immunotherapy and gene therapy

1997 - 1999 細胞性免疫の誘導に基づく免疫療法

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Toshihiro Sugi, Yuki Katoh, Toshikatsu Ikeda, Daichi Seta, Takashi Iwata, Hiroshi Nishio, Masaki Sugawara, Daiki Kato, Kanoko Katoh, Kei Kawana, et al. SCD1 inhibition enhances the effector functions of CD8+ T cells via ACAT1-dependent reduction of esterified cholesterol. Cancer science. 2023
岩田卓, 西尾浩, 野上侑哉, 松井友哉, 松田理沙, 菅原正貴, 陳冠良, 藤田知信, 舩越建, 平井郁子, et al. ここまで来た、婦人科がんにおける免疫療法進行子宮頸癌に対する腫瘍浸潤リンパ球輸注療法. 日本癌治療学会学術集会抄録集. 2023. 61回. OWS10-4
片桐楓汀, 西尾浩, 香川昌紀, 今川遼太郎, 佐々木千代美, 村木智子, 菅原正貴, 松田理沙, 杉山重里, 岩田卓, et al. HNF1betaを治療標的とした卵巣明細胞癌における新規複合的免疫療法の確立(Establishment of novel combination mmunotherapy by targeting HNF-1beta in ovarian clear cell carcinoma). 日本癌学会総会記事. 2023. 82回. 1164-1164
三沢彩, 大多茂樹, 池本篤史, 滝本哲也, 河上裕. 抗PD-1抗体の治療奏効と相関するCASCはT細胞代謝を制御する. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 175-175
Yamamoto Y, Shimada S, Akiyama S, Tsukihara S, Kabashima A, Tokunaga M, Kinugasa Y, Kawakami Y, Tanaka S. RTP4 silencing provokes tumor-intrinsic resistance to immune checkpoint blockade in colorectal cancer. J Gastroenterol. 2023. 58. 540-553

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片桐楓汀, 西尾浩, 香川昌紀, 今川遼太郎, 今川遼太郎, 佐々木千代美, 村木智子, 菅原正貴, 松田理沙, 杉山重里, et al. Establishment of novel combination mmunotherapy by targeting HNF-1beta in ovarian clear cell carcinoma. 日本癌学会学術総会抄録集(Web). 2023. 82nd
KATOH Yuki, KATOH Yuki, KATOH Yuki, YAGUCHI Tomonori, YAGUCHI Tomonori, KUBO Akiko, IWATA Takashi, IWATA Takashi, MORII Kenji, MORII Kenji, et al. Combination immunotherapy targeting stearoyl-CoA desaturase 1 (SCD1) with immunosuppressive activity. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
加藤侑希, 加藤侑希, 加藤侑希, 谷口智憲, 岩田卓, 岩田卓, 川名敬, 河上裕, 河上裕. がん微小環境における脂質代謝の制御は,抗腫瘍免疫応答を増強し,抗PD-1抗体の効果を増強する. Reproductive Immunology and Biology. 2021. 36. 1-2
大多茂樹, 大多茂樹, 伊澤直樹, 三沢彩, 三沢彩, 加藤侑希, 久保亜紀子, 門脇重憲, 三梨桂子, 仁科智裕, et al. 胃がんにおける複合がん免疫療法効果予測のためのバイオマーカー候補の同定. 日本癌学会学術総会抄録集(Web). 2021. 80th
三沢彩, 三沢彩, 大多茂樹, 大多茂樹, 川村直, 住本秀敏, 酒口るみ, 今川遼太郎, 加藤侑希, 辻川敬裕, et al. STK24による免疫抑制因子制御を介した腫瘍免疫回避. 日本癌学会学術総会抄録集(Web). 2021. 80th

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癌治療剤
悪性黒色腫の診断マーカー、ヒスタチン-1タンパク質の機能抑制物質を含有する医薬組成物、および、免疫抑制剤
ペプチド、樹状細胞、細胞傷害性T細胞、白血病ワクチン、及び白血病受動免疫療法剤
がん免疫療法
がんワクチン

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Immunobiology of Melanoma.
Springer. 2018
免疫チェックポイント阻害薬-作用機序と治療成績
医学書院 2018
複合がん免疫療法の開発
NTS 2017
免疫応答を利用した癌治療の現状と課題
NTS 2017
皮膚がんの遺伝学的検査
メディカル・サイエンス・インターナショナル 2017

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Response of nivolumab monotherapy in 124 Japanese patients with advanced melanoma; Interim analysis of prospective observational study (CREATIVE study)
(ESMO Asia Congress 2019 2019)
Immunoscore predicts significant differences in time to recurrence in stage I colon cancer patients
(ESMO Asia Congress 2019 2019)
がん治療における細胞免疫療法の最近の進捗
(第78回日本癌学会学術総会 2019)
シングルセルRNAシークエンス解析によるメラノーマ患者におけるPD-1抗体治療反応性と相関する末梢血CD8+T細胞サブセット
(第78回日本癌学会学術総会 2019)
固形がんに対するCAR-T細胞療法を用いた複合免疫療法
(第78回日本癌学会学術総会 2019)

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医学部国際交流委員会委員
2003 - 2005
国際交流委員会委員
2001 - 2003
国際交流委員会委員
1999 - 2001

1974 - 1980 Keio University School of Medicine
1971 - 1974 Senior High School at Komaba, Tokyo University of Education,

博士(医学) (Keio University)

2023/04 - 現在 Graduate School of Medicine, Intenational University of Health and Welfare Director
2019/04 - 現在 Keio University Professor emeritus
2019/04 - 現在 School of Medicine, International University of Health and Welfare Department of Immunology Professor
2019/04 - 2023/03 International University of Health and Welfare School of Medicine Dean
2019/04 - 2021/03 Keio University Division of Cellular Signaling, Institute for Advanced Medical Research, School of Medicine Professor

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2023/03 - 現在日本臨床腫瘍学会功労会員
2022/01 - 現在日本癌学会名誉会員
2021/10 - 現在日本臨床免疫学会監事
2021/04 - 現在日本がん免疫学会アドバイザー
2021 - 現在 Japanese Society of Immunotherapy for Hematological Disorder (JSIHD Honorary member

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2020/10 - JAPANESE CANCER ASSOCIATION The Mataro Nagayo Prize
2018/12 - Society of Immunology JSI Human Immunology Award Development of cancer immunotherapy through understanding human cancer immunopathology
2018/11 - Keio University Gijuku Prize Development of cancer immunotherapy through understanding human cancer immunopathology
2015 - 公益財団法人東京生化学研究会研究助成金
2011 - Academy of Cancer Immunology, Cancer Research Institute, New York

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American Association of Immunologists , American Association for Cancer Research , International Society of Biological Therapy of Cancer (iSBTc) , SITC(Society for Immunotherapy of Cancer) , Japanese Association of Cancer Immunology , 日本再生医療学会 , 日本研究皮膚科学会 , Japanese Society of Medicine , 日本リウマチ学会 , Japanese Society of Hematology , Japanese Society of Medical Oncology , Society for Fundamental Cancer Immunology , Japanese Society of Clinical Immunology , Japanese Association of Cancer