2017 - 2019 Biomarker development and clinical application by extraction of pathogenesis-related factors from early fibrosis foci of interstitial pneumonia
2016 - 2018 The identification of the novel gene mutation and development of the novel therapy for dyskeratosis congenita
2014 - 2017 MicroRNA and exosome in interstitial pneumonia
2015 - 2017 The gene therapy for hypophosphatasia animal model
2015 - 2017 Development a novel gene therapy for Lysosomal disease with neurological disorders
2014 - 2017 Development of mouse model and therapy of Diamond-Blackfan anemia
2013 - 2016 Comprehensive analysis of neuropathic pain-specific microRNA cluster
2014 - 2016 Elucidation of molecular mechanism of survivin in inflammatory lung disease and development of new gene therapy method
2011 - 2015 Physiological function of the rat SDN-POA analyzed by sst-siRNA recombinant adenovirus vector
2013 - 2015 Development of regenerative medicine and cell therapy for inherited metabolic diseases using hypophosphatasia mice
2013 - 2015 Analysis of lymphoplasmacyte infiltrating fibrotic lung lesion using samples from human lung diseases and RA lung model in D1CC mice
2012 - 2014 Development of novel gene therapy for CNS disorders of lysosomal diseases
2011 - 2013 Analysis of angiogenetic factor in interstitial pneumonia
2011 - 2013 Development of molecular mechanism and therapy of Diamond-Blackfan anemia
2010 - 2012 Perinatal gene therapy for severe genetic diseases
2010 - 2012 The novel gene therapy using adeno-associated viral vector mediatedMDA7/IL-24 for human pancreatic cancer
2008 - 2010 Development of mouse model and novel gene therapy for Diamond-Blackfan anemia
2008 - 2010 Development of novel bone marrow transplantation for treatment of CNS disorders in lysosomal disease.
2006 - 2007 Molecular mechanism and development of gene therapy for Diamond-Blackfan anemia
2005 - 2007 Non-invasive gene therapy for inherited neurodegenerative disorders (How to cross the BBB?)
2003 - 2004 Gene therapy for rheumatoid arthritis using transduction with angiogenesis inhibitory factor
2002 - 2004 Therapeutic strategies for inherited neurodegerative disorders using gene transfer and stem-cell transplantation technologies
2000 - 2004 HIVベクターの開発
2002 - 2003 血管新生抑制物質による多発性骨髄腫の新規治療法(遺伝子治療)の開発
1997 - 1998 遺伝子治療を目的とた安全でかつ高率な組織特異的遺伝子導入法の開発
1996 - 1997 HIVベクターによる血球系細胞(リンパ球、造血幹細胞)への遺伝子導入
1995 - 1996 GENE TRANSFER INTO NON DIVIDING CELLS BY MEANS OF HIV
1995 - 1996 アデノ随伴ウィルスベクターによる造血幹細胞への遺伝子導入
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Papers (115)：
Tae Matsumoto, Sonoko Narisawa, José Luis Millán, Koichi Miyake. Gene Therapy for Hypophosphatasia: Current Management and Future. Genetically Modified Organisms [Working Title]. 2024
Flavia Amadeu de Oliveira, Fatma F Mohamed, Yuka Kinoshita, Sonoko Narisawa, Colin Farquharson, Koichi Miyake, Brian L Foster, Jose Luis Millan. Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP-D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia. JBMR plus. 2023. 7. 1. e10709
Noriko Miyake, Koichi Miyake, Atsushi Sakai, Motoko Yamamoto, Hidenori Suzuki, Takashi Shimada. Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A. Scientific reports. 2021. 11. 1. 20513-20513
Tae Matsumoto, Koichi Miyake, Noriko Miyake, Osamu Iijima, Kumi Adachi, Sonoko Narisawa, José Luis Millán, Hideo Orimo, Takashi Shimada. Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection. Molecular therapy. Methods & clinical development. 2021. 22. 330-337
Yuka Kinoshita, Fatma F Mohamed, Flavia Amadeu de Oliveira, Sonoko Narisawa, Koichi Miyake, Brian L Foster, José Luis Millán. Gene Therapy Using Adeno-Associated Virus Serotype 8 Encoding TNAP-D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl-/- Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2021. 36. 9. 1835-1849
Gene Therapy-Principles and Challenges
InTech 2015
Novel Gene Therapy Approaches
InTech 2013
Viral Gene Therapy
InTech 2011
Lectures and oral presentations (18)：
Direct comparison between single-stranded and self-complementary type 9 AAV vector to treat adult MLD model mice by intravenous injection
(he 24th Annual Meeting of Japan Society of Gene Therapy 2018)
Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of adeno-associated virus vector
(第75回脳神経外科学会学術総会 2016)
Involvement of miR-17-92 cluster in the neuropathic pain and axonal growth.
(第88回日本薬理学会年会 2015)
