Sasaoka Toshiyasu

ササオカトシヤス | Sasaoka Toshiyasu

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www.pha.u-toyama.ac.jp/clinphar/index-j.html

Research field (2)： Obstetrics and gynecology , Metabolism and endocrinology

Research keywords (2)：内分泌・代謝学 , Endocrinology & Metabolism

Research theme for competitive and other funds (32)：

2024 - 2028 脂肪組織の可塑性メモリーを規定するエピゲノム制御による肥満リバウンド抑止法の開発
2022 - 2026 飽食病態改善のための「嗅覚」刺激を介した飢餓対応型代謝の活用と脂質利用の拡大
2021 - 2024 血管リモデリングが誘導する脂肪幹細胞制御因子の同定による新規肥満病態改善法の創出
2021 - 2023 オレキシンが奏でる中枢性代謝統合による非アルコール性脂肪肝炎と肝癌の撲滅
2019 - 2022 Preventive and therapeutic significance of CD52 in metabolic diseases with obesity

2019 - 2021 Strengthen of willdynamics via the olfactory system to prevent the vicious cycle of depression and diabetes

2018 - 2021 Mechanism of adipose angiogenesis by the cooperative action of angiogenic factors

2018 - 2021 The finding of functional link between olfactory and metabolic system: a novel perspective on diabetes research

2015 - 2018 Development of therapeutic strategy against obesity-associated chronic inflammations based on the mechanism involved in sex-specific difference of Treg localization in adipose tissue.

2015 - 2018 Significance of homeodynamic regulation by hypothalamic orexin in preventing obesity and type 2 diabetes

2015 - 2018 Studies on novel insulin-sensitizing agent based on SHIP2 inhibitors

2015 - 2018 Discovery of SHIP2 inhibitors for novel drugs against type 2 diabetes accompanying dementia of Alzheimer's type

2015 - 2017 Impact of the cooperative effect of estrogen and orexin on abnormalities with emotion and metabolism in menopausal mice

2012 - 2016 Development of therapeutics for diabetes with dysregulation of sleep/wake rhythm and depressive disorders by timed regulation of hypothalamic orexin system

2013 - 2015 Role of estrogen via the recruitment of Treg in the control of glucose homeostasis in female mice.

2012 - 2015 Enhanced PDGF signaling contributes adipose tissue angiogenesis, expansion, and systemic glucose intolerance in obesity.

2012 - 2015 Daily rhythmic regulation of glucose metabolism by hypothalamic orexin system: a chronotherapeutic target for type 2 diabetes

2011 - 2012 Development of a new therapeutics of gestational diabetes by inhibition of the central action of lipid phosphatase

2009 - 2011 Involvement of hypothalamic orexin in the development of insulin resistance associated with depression

2008 - 2010 Role of lipid phosphatase in brain insulin resistance related to neuroprotection and memory function

2007 - 2008 Central role of orexin in the regulation of insulin-mediated glucose metabolism

2005 - 2008 Synthetic Studies on Poison-frog Alkaloids As Antagonists on nicotinic Acetylcholine Receptors

2005 - 2006 Clarification of the mechanism of estrogen-induced regulation of insulin sensitivity in the pathogenesis of type 2 diabetes in female

2004 - 2005 LC-MS及びTOF-MSによる植物成分の解析:糖尿病合併症の予防・治療薬の開発

2001 - 2002 Regulation of insulin-induced metabolic action in whole body by lipid phosphatase

1999 - 2000 Impact of the regulation of PI3-kinase product on insulin action and its role in the disease state.

1997 - 1998 インスリン非依存性糖尿病(NIDDM)におけるShc蛋白異常の解析

1996 - 1996 Shc蛋白のインスリン代謝作用における役割の標的細胞での解析

インスリン抵抗性病態の改善によるメタボリック症候群の新規治療法の開発

加齢と性差に着目した2型糖尿病の新規時間治療法の開発

覚醒・睡眠と嗅覚による糖/脂質代謝のダイナミック制御による糖尿病予防と治療

Study on the Mechanisms of insulin signaling

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Papers (128)：

Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka. Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity. Molecular Medicine. 2024. 30. 1
Hiroshi Tsuneki, Masanori Sugiyama, Kiyofumi Sato, Hisakatsu Ito, Sanaka Nagai, Kanta Kon, Tsutomu Wada, Nao Kobayashi, Takuya Okada, Naoki Toyooka, et al. Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice. European journal of pharmacology. 2023. 961. 176190-176190
Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka. A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice. Nutrition & Metabolism. 2023. 20. 1
Hiroshi Tsuneki, Masanori Sugiyama, Toshihiro Ito, Kiyofumi Sato, Hiroki Matsuda, Kengo Onishi, Koharu Yubune, Yukina Matsuoka, Sanaka Nagai, Towa Yamagishi, et al. Food odor perception promotes systemic lipid utilization. Nature metabolism. 2022. 4. 11. 1514-1531
Zydrune Polianskyte-Prause, Tuomas A Tolvanen, Sonja Lindfors, Kanta Kon, Laura C Hautala, Hong Wang, Tsutomu Wada, Hiroshi Tsuneki, Toshiyasu Sasaoka, Sanna Lehtonen. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. International journal of biological sciences. 2022. 18. 5. 1852-1864

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MISC (132)：

杉山聖典, 恒枝宏史, 湯舟香春, 山岸永和, 永井真華, 佐藤清史, 松田樹大, 大西兼悟, 和田努, 笹岡利安. 嗅覚系による脂質恒常性の制御と2型糖尿病の防止効果. 糖尿病(Web). 2022. 65. Suppl
Z. Polianskyte-Prause, T. A. Tolvanen, S. Lindfors, K. Kon, H. Wang, V. Dumont, P-H. Groop, T. Wada, H. Tsuneki, T. Sasaoka, et al. Novel small molecules targeting lipid phosphatase SHIP2: new treatments for type 2 diabetes. DIABETOLOGIA. 2017. 60. S226-S227
Akari Ishikawa, Tsutomu Wada, Eri Watanabe, Hayate Hasegawa, Yuto Nakamura, Hiroshi Tsuneki, Yoko Ishii, Masakiyo Sasahara, Toshiyasu Sasaoka. Impact of Mineralocorticoid Receptor Blockade on Energy Metabolism and NLRP3-Inflammasome Activation in Diet-Induced Obese Mice. DIABETES. 2017. 66. A541-A542
Watanabe Eri, Wada Tsutomu, Onogi Yasuhiro, Tsuneki Hiroshi, Sasaoka Toshiyasu. Anagliptin, a DPP-4 Inhibitor, Attenuates Diet-Induced Obesity by Modulating Adipose Tissue Angiogenesis in Mice. DIABETES. 2017. 66. A541-A541
H. Tsuneki, K. Kon, T. Wada, T. Sasaoka. The ameliorating effect of suvorexant, a dual orexin receptor antagonist, on glucose metabolism in type 2 diabetic db/db mice. DIABETOLOGIA. 2016. 59. S119-S119

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Books (4)：

視床下部オレキシンによる代謝調節
科学評論社 2015
睡眠とインスリン抵抗性-オレキシンによる代謝調節-
医歯薬出版 2015
インスリン受容体
メディカルレビュー社 2015
インスリン抵抗性と認知機能
日本臨床社 2014

Education (4)：

- 1989 Shiga University of Medical Science
- 1989 Shiga University of Medical Science Graduate School, Division of Medicine
- 1985 Shiga University of Medical Science Undergraduate School of Medicine Faculty of Medicine
- 1985 Shiga University of Medical Science Faculty of Medicine

Professional career (1)：

Ph.D. (Shiga University of Medical Science)

Work history (4)：

2005/05 - 現在 University of Toyama Department of Clinical Pharmacology Professor
2000 - 2005 University of Toyama Department of Clinical Pharmacology Associate Prifessor
1995 - 2000 Toyama Medical & Pharmaceutical University, Assistant Professor
1995 - 2000 University of Toyama First Department of Medicine Assistant Professor

Awards (2)：

2003 - 富山県とやま賞
1998 - 日本内分泌学会研究奨励賞

Association Membership(s) (11)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本薬学会 , アメリカ糖尿病学会 , 日本内分泌学会 , 日本糖尿病学会 , 日本内科学会 , American Dabetes Association , Japan Pharmacology Society , Japan Endocrinology Society , Japan Diabetes Society , Japanese Society of Internal Medicine

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