Takashiba Shogo

2019 - 2023 Development of periodontal tissue regeneration therapy for horizontal alveolar bone resorption with collagen-binding FGF-2

2019 - 2023 超高齢社会での応用を目指す低分子化合物terreinの標的分子の同定・機能解析

2019 - 2022 Metabolic control of periodontal fibrotic diseases by fluorides: A basic study

2020 - 2022 Development of novel protectant for oral mucosal disorder during cancer chemotherapy

2018 - 2021 Development of a New Evaluation Method for Exercise Training Using Mitochondrial Activation of Peripheral Blood Mononuclear Cells

2018 - 2021 Biological effect and preventive method for human serum albumin binding to transboundary air borne PM2.5.

2018 - 2021 Investigation of integrin peptide therapy regulating stem cell niche for periodontal regeneration

2018 - 2021 Elucidation of pathology of periodontal disease, sarcopenia, and diabetes centered on inflammation-aging

2018 - 2021 Study on pathogenicity of Rothia mucilaginosa and development of the anti-infective therapy

2016 - 2019 Application of anti-inflammatory small molecule compound, terrein and its novel analogue, for the treatment of endodontic or periodontal diseases.

2016 - 2018 Functional analysis of HMGB1 as an inflammatory mediator in periodontitis

2015 - 2018 Growth inhibition of selected bacterial species by peptide nucleic acids for control of oral microflora

2014 - 2017 Establishment of the concept of "febrile neutropenia caused by odontogenic infection" as periapical periodontitis

2014 - 2017 Induction of Migration of Periodontal Ligament Cells by Selective Regulation of Integrin Expression

2013 - 2017 An analysis of shared risk cytokine gene for periodontitis, diabetes mellitus, and rheumatoid arthritis

2012 - 2015 Application of antisense PNA as antibiotics against periodontal pathogens

2013 - 2014 唾液腺体性幹細胞とiPS細胞を用いた唾液腺機能再生に関する研究

2012 - 2014 Cohort Study on the Relation between Infection of Periodontopahic Bacteria and Safety of Dental Implants

2011 - 2013 Construction of the prevention system of a Bisphosphonate-Related Osteonecrosis of the Jaw judging from an intraoral infection degree

2011 - 2013 Cell cycle atlas of periodontium

2010 - 2012 Investigation on the automation and speeding up ofmeasurement of the plasma IgG antibody titers against periodontopathic bacteria

2010 - 2012 How periodontitis can affect prostate cancer metastasis?

2010 - 2011 The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

2009 - 2011 Chronic infection and immune response in COPD patients

2009 - 2011 Cross reactivity of archaeal chaperonin with human CCT involved in the pathogenesis of periodontitis and autoimmune disease

2008 - 2010 Healing mechanism of rat experimental periapical lesions targeting laminin γ2 expression

2008 - 2010 Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients

2008 - 2010 Investigation of the mechanisms of osteogenic differentiation by RhoA in periodontal ligament cells for cell transplantation

2007 - 2008 New bactericide delivery system for oral care

2007 - 2008 Molecular cloning and functional analysis of non-coding RNA expressed in periodontal bacteria

2007 - 2008 付着歯肉の分化に関連した特異的遺伝子・蛋白の同定とその機能解析

2006 - 2008 The wound healing mechanisms and regenerative therapy in dental pulp and periapical tissues

2006 - 2008 Mail Medicine using Fingertip Plasma for Screening and Monitoring Periodontitis

2005 - 2008 Establishment of Information Basis for Tooth Regeneration

2006 - 2007 マイクロバブルを用いた口腔嫌気性菌除去方法の検討

2005 - 2007 New Approach to the Study on Oral Biofilm Infectious Diseases by Metagenomic Analysis

2004 - 2007 Integrate research of genomics and proteomics of novel molecular targets for development of periodontal diseases cure

2005 - 2006 The effect on dentin-pulp complex by FIP-2 isolated from rat wounded pulp

2005 - 2006 カテプシン-Lプロモーターの薬剤応答配列を標的とした歯肉増殖症の治療法開発

2004 - 2006 A study of the healing mechanisms of destructive periapical lesions and regenerative medicine for periapical bone defect

2004 - 2006 Diagnostic approaches by a susceptibility determination based on gene polymorphism in Japanese periodontitis patients.

2004 - 2006 Preparation of self-organized nano-structured apatite and the protein adsorption property

2003 - 2006 X-ray Crystal Structural Analysis of Bacterial Iron Binding Protein and Development for New Antibiotics

2005 - 2005 歯周病細菌に対する血清抗体価測定法の標準化に関する調査研究

2004 - 2005 バイオフィルムにおける歯周病細菌病原因子発現様態のゲノム-プロテオミクス解析

2002 - 2005 Gene Therapy for Periodontal Diseases -Regulation of host response by local gene delivery-

2004 - 2004 歯周靭帯細胞における機械的ストレス応答性遺伝子のグルーピングと転写機構

2003 - 2004 Regulation of gene expression of periodontal virulence factors during biofilm formation

2003 - 2004 Gene profiling of periodontal pathogens in periodontal lesion

2003 - 2004 日本人の腎結石から分離した新種ナノバクテリアに関する多面的解析

2003 - 2004 口腔インプラントの骨結合獲得難易度を予測する生物学的診断法の開発

2002 - 2004 Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.

2002 - 2003 Development of the methods for application of the factors that biologically accelerate reparative dentin formation

2002 - 2003 Role of a novel transcription factor for TNF-α, LITAF, on the pathogenesis of periodontitis

2002 - 2003 歯周病原性細菌によって起こる誤嚥性肺炎の分子免疫学的病態の研究

2000 - 2003 Project study of tissue regeneration with tissue engineering

2001 - 2002 歯周組織の治癒に関わる遺伝子の研究

2000 - 2002 Study on the influence of periapical lesions on systemic health

2000 - 2001 Molecular cloning of the factors that biologically accelerate reparative dentin formation

2000 - 2001 Periodontal Treatment by Regulation of Novel TNF-α Transcription Factor in Monocytes

2000 - 2001 Microbiological examination for periodontal therapy

2000 - 2001 Factor for induction of root resorption

2000 - 2001 歯周病の発症と進行に関わる交叉免疫応答を誘導する抗原蛋白

1999 - 2001 Study for preservation of dentin using local gene deliveryof dentin-specific genes

2000 - 2000 早期発症型歯周炎の病態解析と診断基準確立に向けた共同研究の企画調査

1999 - 2000 上皮由来抗菌ペプチドの利用による歯周病原性細菌の感染予防にむけて

1998 - 1999 The diversified research on. the genes related periodontal disease

1998 - 1999 Study on the pathogenesis of periodontal disease in patients with Down's syndrome

1998 - 1999 Studies on bone regeneration by application of osteoblast differentiation marker, Cbfal, gene products

1997 - 1999 Study of Periodontal Tissue Reconstruction using Various Growth Factors

1997 - 1999 Differentiation from dental pulp cells to odontoblasts and calcification of the pulp.

1997 - 1998 Basic studies on adaptation the immune therapy to the patients with periodontal diseases by using synthetic peptides as an immunogen

1997 - 1998 Studies on differentiation and proliferation factors for induction of biological reparative dentin formation

1996 - 1998 Study on the control of periodontal ligament fibroblast functions by transforming growth factor

1997 - 1997 L-セレクチンを介したβ_2-インテグリンのシグナル伝達機構から捉える歯周病病態

1996 - 1997 Regulation of osteogenic function of periodontal ligament fibroblast by 1d, 25-dihydroxy vitamin D3 receptor inducing factor.

1996 - Molecular biological study on tissue regeneration

1994 - 1995 Analyzes of periodontitis status from changes in gingival fibroblasts subpopulation

1994 - 1995 Molecular biological study on the IL-8 production in inflamed gingiva

1992 - 1993 Study on the interleukin-2 producing capacity in the patients with periodontitis

1991 - 1993 Molecular Basis of Leukocyte Adhesion Molecules in Early-onset Periodontitis Patients.

1992 - Study on molecular pathogenesis of inflammation

1991 - 1991 歯周病患者に検出されたHLA遺伝子変異の解析

Study on genetics of periodontal diseases