FUJISAWA J.

フジサワジユンイチ | FUJISAWA J.

Affiliation and department：
Job title： Professor
Homepage URL (1)： http://www3.kmu.ac.jp/microbiol/

Research field (4)： Virology , Cell biology , Molecular biology , Laboratory animal science

Research theme for competitive and other funds (41)：

2018 - 2021 Expression and immunogenicity of recombinant vaccinia virus containing the HTLV-1 env gene
2018 - 2020 Role of tumor microenvironment in the chronic infection HTLV-1 and the ATL development
2015 - 2018 根治不能肝腫瘍に対する増殖型遺伝子組換えウイルスを用いた新治療法の臨床応用研究
2015 - 2018 Analysis of factors involved in the establishment of asymptomatic carrier state in HTLV-1 infected humanized mice
2012 - 2015 Efficacy of third-generation oncolytic herpes simplex virus type 1 for advanced hepatocellular carcinoma

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Papers (82)：

Takataro Fukuhara, Yoshihiro Ueda, Sung-Il Lee, Tokifumi Odaka, Shinsuke Nakajima, Jun-Ichi Fujisawa, Kazu Okuma, Makoto Naganuma, Kazuichi Okazaki, Naoyuki Kondo, et al. Thymocyte Development of Humanized Mice Is Promoted by Interactions with Human-Derived Antigen Presenting Cells upon Immunization. International Journal of Molecular Sciences. 2023. 24. 14. 11705-11705
Koma Takaaki, Odaka Tokifumi, Lee Sung-Il, Doi Naoya, Kondo Tomoyuki, Okuma Kazu, Fujisawa Jun-Ichi, Adachi Akio, Nomaguchi Masako. Humanized mice generated by intra-bone marrow injection of CD133-positive hematopoietic stem cells: application to HIV-1 research. Frontiers in Virology. 2023. 3
Atsuhiko Hasegawa, Megumi Murata, Tomoka Fujikawa, Kuniko Katagiri, Yoshiko Nagano, Takao Masuda, Madoka Kuramitsu, Shinsuke Nakajima, Jun-ichi Fujisawa, Kazu Okuma, et al. Vaccination with short-term-cultured autologous PBMCs efficiently activated STLV-1-specific CTLs in naturally STLV-1-infected Japanese monkeys with impaired CTL responses. PLOS Pathogens. 2023. 19. 2. e1011104-e1011104
Misaki Matsuo, Takaharu Ueno, Kazuaki Monde, Kenji Sugata, Benjy Jek Yang Tan, Akhinur Rahman, Paola Miyazato, Kyosuke Uchiyama, Saiful Islam, Hiroo Katsuya, et al. Identification and characterization of a novel enhancer in the HTLV-1 proviral genome. Nature Communications. 2022. 13. 1
Masateru Hiyoshi, Naofumi Takahashi, Youssef M. Eltalkhawy, Osamu Noyori, Sameh Lotfi, Jutatip Panaampon, Seiji Okada, Yuetsu Tanaka, Takaharu Ueno, Jun-ichi Fujisawa, et al. M-Sec induced by HTLV-1 mediates an efficient viral transmission. PLOS Pathogens. 2021. 17. 11. e1010126-e1010126

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MISC (8)：

Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Jun-ichi Fujisawa. Carrier model of HTLV-1 infection in humanized NOG mice. Retrovirology. 2014. 11(Suppl 1). P42
Takaharu Ueno, Runze Xun, Mineki Saito, Kenta Tezuka, Yuetsu Tanaka, Jun-ichi Fujisawa. Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression. Retrovirology. 2014. 11(Suppl 1). P146
Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Hidekatu Iha, Jun-ichi Fujisawa. Inhibition of ATL development in humanized mouse model by AZT/IFN treatment. Retrovirology. 2014. 11(Suppl 1). P43
Jun-ichi Fujisawa, Kenta Tezuka, Runze Xun, Mami Tei, Norihiro Takenouchi, Masakazu Tanaka. ATL-like overgrowth and clonal expansion of HTLV-1 infected CD25+ CD4+ T- lymphocyte in humanized-NOG mouse model. Retrovirology. 2011. 8(Suppl 1). A13
Kenta Tezuka, Runze Xun, Mami Tei, Takaharu Ueno, Masakazu Tanaka, Norihiro Takenouchi, Jun-ichi Fujisawa. Inverse correlation between Tax and CD25 expressions in HTLV-1 infected CD4 T-cells in vivo. Retrovirology. 2011. 8(Suppl 1). A14

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Books (3)：

第IV章ウイルス学・分子生物学 4 HTLV-1のウイルス学「HTLV-1と疾患」
文光堂 2007 ISBN:9784830614200
「医学書院医学大辞典」
医学書院 2003 ISBN:9784260136518
【ウイルス発癌の最前線】 HTLV-1感染細胞腫瘍化におけるウイルス発現抑制機構の関与
2002

Lectures and oral presentations (82)：

NAD+-poly(ADP-ribose)代謝を標的とした創薬研究の新展開基礎から臨床応用までポリADPリボシル化経路とAKT経路との関連について
(日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 2015)
Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression
(Retrovirology 2014)
ATL-like overgrowth and clonal expansion of HTLV-1 infected CD25+ CD4+ T- lymphocyte in humanized-NOG mouse model
(Retrovirology 2011)
Inverse correlation between Tax and CD25 expressions in HTLV-1 infected CD4 T-cells in vivo
(Retrovirology 2011)
HTLV-1の個体内発現制御における低酸素シグナルの関与
(第30回日本分子生物学会年会・第80回日本生化学会大会合同大会 2007)

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Awards (1)：

1990/07 - 日本癌学会第9回日本癌学会奨励賞

Association Membership(s) (5)：

The Molecular Biology Society of Japan , Japanese Society for Bacteriology , The Japanese Cancer Association , The Japanese Society for AIDS Research , The Japanese Society for Virology

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