Matsuda Yasunobu

2017 - 2020 Creation of next-generation cell therapy for diabetes with focus on nesidioblastic change

2017 - 2020 Regenetative medicine using decidouous teeth preparing for future diseases

2017 - 2020 Elucidation of clinical significance and chemotherapy resistance mechanism of NAD(P)H:quinone oxidoreductase 1 (NQO1) expression for colorectal liver metastasis

2016 - 2019 The mechanism of exosome-mediated drug resistance in hepatoma cells

2016 - 2019 Establishment of new treatment strategy for NASH by elucidating the mechanisms of fibrosis progression due to nocturnal intermittent hypoxia.

2016 - 2019 Elucidation of the signal expression mechanism in the mTOR cell and development of the rapamycin treatment in the hepatoblastoma

2016 - 2019 Histochemical analysis and modification of the natural healing process of the large defect of rabbit trachea.

2015 - 2018 Elucidation of molecular mechanism of lipid mediator involved in metastatic ability of biliary tract cancer / pancreatic cancer and clinical application

2015 - 2018 肝内免疫監視不全の回復と抗体関連型拒絶反応を応用した肝癌に対する新規治療法の開発

2014 - 2017 Elucidation of the mechanism of drug resistance in colorectal cancer by p62-Keap 1-Nrf2 pathway

2013 - 2016 Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis C

2012 - 2015 Importance of NK cell function in the mechanisms responsible for tumor evasion of immune surveillance against hepatocellular carcinoma after liver transplantation

2012 - 2015 Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma

2012 - 2015 Effects of rapamycin on granulation formation in response to centrally-doubled coiled stents as a tracheal substitute.

2012 - 2015 Molecular Analysis of Cytokine-mediated Sorafenib Resistance

2010 - 2013 DNA障害の修復機構をマーカーとした新しいインターフェロン治療の開発

2009 - 2013 臓器移植における再生間葉系肝幹細胞門脈内投与による新たな免疫寛容誘導法の確立

2010 - 2012 Development of new IFN-strategy that based on DNA repair mechanism

2009 - 2012 Development of New Strategy of Immunological Tolerance Inductionby Intraportal administration of donor specific Mesenchymal hepatic stem cell in OrganTransplantation

2009 - 2011 胆管癌における53BP1を介したDNA損傷修復機構の解明及びその臨床的意義

2009 - 2011 Prospective analysis of DNA damage and repair markers in the patients with high risk of hepatocellular cancer

2009 - 2011 Importance of NK cells and intrahepatic immune responses for the acceleration of hepatitis C after liver transplantation

2009 - 2011 Development of a new endoscopic therapy using RNAi for intestinal fibrosis of Crohn's disease

2010 - 2010 肝がんにおける分子標的薬耐性機構の解析

2007 - 2008 Manipulating the stromal-derived factor 1 function in mouse liver cirrhosis

2006 - 2007 Analysis of the innate immune responses in the liver of patients with chronic hepatitis C following liver transplantation to develop a novel immunotherapy for the recurrent hepatitis C infection

2004 - 2006 糖鎖を標的とした肝癌遺伝子治療戦略

2005 - 2005 C型肝炎に対するインターフェロン・リバビリン併用療法の治療マーカーの探索同定

2002 - 2003 Development of a new cell therapy by adoptive transfer of regulatory T cells to induce immunological tolerance for the transplanted liver

1999 - 2000 Development of a new system identifying mutated DNA in the plasma

1999 - 1999 肝がんにおける細胞周期調節機構の解析

1996 - 1997 原発性胆汁性肝硬変の肝移植後の再発機序に関する研究

1996 - 1996 原発性胆汁性肝硬変の肝移植後の再発機序に関する研究

1990 - 1990 肝細胞増殖因子 (hepatocyte growth factor)による肝再生機構