NOBUHIKO KOJIMA

コジマノブヒコ | NOBUHIKO KOJIMA

Affiliation and department：
Job title： Professor

Research field (2)： Neuroscience - general , Neuropathology

Research keywords (11)：行動テストバッテリー , トランスジェニックマウス , ノックアウトマウス , 樹状突起スパイン , 遺伝子発現 , シナプス可塑性 , 学習記憶 , dendritic spine , gene expression , synaptic plasticity , learning&memory

Research theme for competitive and other funds (14)：

2014 - 2017 情動記憶における核ーシナプス間情報伝達を担う分子の探索
2011 - 2015 PKN1 regulates metaplasticity in hippocampus
2010 - 2015 スパイン内アクチン細胞骨格の多面的制御メカニズムとその脳機能における役割の解明
2010 - 2013 情動記憶の分子機構に関わるmicroRNAの同定とその機能解析
2010 - 2011 Mapping of the developmental stages of neurons in the brain using the radiosensitivity as an index.

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Papers (54)：

Yuki Kajita, Nobuhiko Kojima, Tomoaki Shirao. A lack of drebrin causes olfactory impairment. Brain and Behavior. 2023. 14. 1. e3354
Mizuno Y, Konishi S, Imai H, Fujimori E, Kojima N, Kajiwara C, Yoshinaga J. Telomere length and urinary 8-hydroxy-2’-deoxyguanosine and essential trace element concentrations in female Japanese university students. J Environmental Science and Health (Part A). 2021. 56. 12. 1328-1334
Matthias D. Seidl, Benedikt Fels, Daniel Kranick, Alexandra Sternberg, Kristina Grimm, Frank T. Stümpel, Florentina Pluteanu, Jan S. Schulte, Alexander Heinick, Nobuhiko Kojima, et al. Induction of ICER is superseded by smICER, challenging the impact of ICER under chronic beta-adrenergic stimulation. The FASEB Journal. 2020. 34. 8. 11272-11291
Mizuno Y, Konishi S, Imai H, Fujimori E, Kojima N, Yoshinaga J. Cadmium exposure and blood telomere length in female University students in Japan. Biological Trace Element Research. 2019
Bohn T, Rapp S, Luther N, Klein M, Bruehl T-J, Kojima N. Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages. Nature Immunology. 2018. 19. 12. 1319-1329

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MISC (67)：

Matthias Dodo Seidl, Iris Hildebrandt, Christian Wolf, Annika Kathrina Steingraeber, Shogo Endo, Nobuhiko Kojima, Wilhelm Schmitz, Frank Ulrich Mueller. The cAMP dependent transcription factor CREM and its isoform ICER inhibit proliferation of vascular smooth muscle cells. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY. 2014. 387. S91-S92
白尾智明, 児島伸彦, 梶田裕貴. B-34 マーモセット脳におけるシナプス可塑性関連蛋白ドレブリンの免疫組織化学的解析. 霊長類研究所年報. 2013. 43. 102-102
N. Koganezawa, A. Puspitasari, N. Kojima, T. Shirao. Acute effect of X-irradiation on adult mouse brain. JOURNAL OF NEUROCHEMISTRY. 2013. 125. 275-276
N. Kojima, T. Shirao. Synaptic vulnerability and disruption of postsynaptic drebrin-actin complex. JOURNAL OF NEUROCHEMISTRY. 2013. 125. 21-22
Matthias Dodo Seidl, Iris Hildebrandt, Christian Klugstedt, Frank Nunes, Shogo Endo, Nobuhiko Kojima, Wilhelm Schmitz, Frank Ulrich Mueller. The function of cAMP responsive element modulator (CREM) in PDGF induced proliferation of vascular smooth muscle cells. FASEB JOURNAL. 2013. 27

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Patents (2)：

気分障害の予防又は治療剤
シナプス成熟障害モデル動物

Books (8)：

Drebrin: From Structure and Function to Physiological and Pathological Roles (Ed by Shirao T, Sekino Y)
Springer 2017
インテグレーテッドシリーズ6 神経科学
東京化学同人 2011
インテグレーテッドシリーズ6 神経科学
東京化学同人 2011
遺伝子と行動
ナカニシヤ出版 2003
廣川ニューロサイエンス 3新しい神経伝達研究法II
廣川書店 2000

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Lectures and oral presentations (161)：

Prenatal exposure to valproic acid in mice leads to abnormalities in synaptic pruning and microglia activation.
(The 101st Annual meeting of Japan Physiological Society 2024)
Alterations in microbiome-gut-brain axis in chronic unpredictable mild stress mice and attempts to normalize them.
(The 46th annual meeting of the Japan Neurosicence Society 2023)
Effect of BTP2 a drebrin inhibitor on drebrin efflux from dendric spine during chemical LTP induction in primary cultured hippocampal neurons.
(The 46th annual meeting of the Japan Neurosicence Society 2023)
Confirmation duration of chronic unpredictable mild stress exposure correlates with changes in M1/M2 polarization and priming of microglia.
(The 46th annual meeting of the Japan Neurosicence Society 2023)
Effect of drebrin inhibitor BTP2 on synaptic function in cultured hippocampal neurons
(Neuro2022 2022)

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Education (3)：

1985 - 1989 Gunma University Graduate School of Medicine (Doctor course)
1983 - 1985 University of Tsukuba Graduate School of Medical Sciences (Master course)
1979 - 1983 University of Tsukuba Second Cluster of Colleges College of Biological Sciences

Professional career (2)：

Master of Medical Sciences (University of Tsukuba)
Doctor of Phylosophy (Gunma University)

Work history (7)：

2013/04 - 現在 Toyo University Faculty of Life Sciences Professor
2008/08 - 2013/03 Gunma University Graduate School of Medicine Department of Neurobiology and Behavior Associate Professor
2005/06 - 2008/07 Gunma University Graduate School of Medicine Department of Neurobiology and Behavior Assistant Professor
2005/04 - 2005/05 Okinawa Institute of Science and Technology Graduate University Initial Research Project Research Scientist
1998/09 - 2005/03 RIKEN Brain Science Institute Neuronal Circuit Mechanisms Research Group Research Scientist

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Association Membership(s) (5)：

International Society for Neurochemistry , 北関東医学会 , 日本生理学会 , 日本神経科学学会 , 日本神経化学会

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