Komatsu Takayuki

コマツタカユキ | Komatsu Takayuki

Affiliation and department：
Job title： Professor

Research field (3)： Virology , Immunology , Bacteriology

Research keywords (7)：モノネガウイルス , ニューモウイルス , パラミクソウイルス , 病原性発現 , 免疫逃避 , インターフェロン , インフラマソーム

Research theme for competitive and other funds (11)：

2023 - 2026 抗インターフェロン能を欠失させた新規メタニューモウイルスワクチンの研究
2023 - 2026 モノネガウイルスに保存された抗インターフェロン機構の解明と治療薬の研究
2020 - 2023 抗インフラマソーム能欠失型ウイルスを利用した新しいウイルス予防・治療法の研究
2017 - 2020 Is inflammasome antagonism of the paramyxovirus V protein important for the pathogenicity ?
2006 - 2008 Human metapneumovirus pathogenicity and its interferon antagonism

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Papers (83)：

Yukie Tanaka, Naoko Morita, Yoshinori Kitagawa, Bin Gotoh, Takayuki Komatsu. Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination. Frontiers in Immunology. 2022. 13
Naoko Morita, Yukie Tanaka, Kenji Takeuchi, Yoshinori Kitagawa, Ryusuke Sakuma, Naoki Koide, Takayuki Komatsu. SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA. Frontiers in microbiology. 2022. 13. 780534-780534
Ryusuke Sakuma, Naoko Morita, Yukie Tanaka, Naoki Koide, Takayuki Komatsu. Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice. Microbiology and immunology. 2021
Naoko Morita, Yukie Tanaka, Erdenezaya Odkhuu, Yoshikazu Naiki, Takayuki Komatsu, Naoki Koide. Sendai virus V protein decreases nitric oxide production by inhibiting RIG-I signaling in infected RAW264.7 macrophages. Microbes and infection. 2020. 22. 8. 322-330
Hitomi Fukatsu, Naoki Koide, Saeko Tada-Oikawa, Kiyora Izuoka, Akihiko Ikegami, Sahoko Ichihara, Tamami Ukaji, Naoko Morita, Yoshikazu Naiki, Takayuki Komatsu, et al. NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model. Molecular medicine reports. 2018. 18. 6. 5279-5285

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MISC (3)：

Gantsetseg Tumurkhuu, Naoki Koide, Jargalsaikhan Dagvadorj, Abu Shadat Mohammod Noman, Imtiaz Iftakhar-E-Khuda, Yoshikazu Naiki, Takayuki Komatsu, Tomoaki Yoshida, Masataka Oda, Masahiro Nagahama, et al. The inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha and nitric oxide production by Clostridium perfringens alpha-toxin and its relation to alpha-toxin-induced intracellular ceramide generation (vol 299, pg 554, 2009). INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY. 2015. 305. 3. 433-433
Abu Shadat M. Noman, Naoki Koide, Imtiaz I. E. Khuda, Jargalsaikhan Dagvadorj, Gantsetseg Tumutkhuu, Yoshikazu Naiki, Takayuki Komatsu, Tomoaki Yoshida, Takashi Yokochi. RIZ1 Regulates Proliferation of Monocytic Leukemia Cells in Response to Tumor Necrosis Factor-alpha Through Activation of P53. JOURNAL OF IMMUNOTHERAPY. 2009. 32. 9. 1007-1007
後藤敏, 小松孝行, 竹内健司. ウイルスによるインターフェロン誘導の抑制--IRF-3の活性化を抑制するウイルス (特集ウイルスの感染防御突破戦略--インターフェロンシステム抑制の分子機構). 蛋白質核酸酵素. 2004. 49. 4. 511-516

Patents (1)：

Education (3)：

Professional career (1)：

Association Membership(s) (4)：

インターフェロン・サイトカイン学会 , 日本細菌学会 , 日本ウイルス学会 , American Society for Microbiology

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