Research field (3)：
Metabolism and endocrinology
, Internal medicine - General
, Molecular biology
Research keywords (2)：
分子医学
, Molecular medicine
Research theme for competitive and other funds (24)：
2020 - 2023 Gene dysregulation by single nucleotide polymorphism of hypoxia-inducible transcription factor in molecular pathology of pulmonary hypertension
2017 - 2020 Molecular pathology for IPAS/HIF-3a gene SNP-mediated pulmonary hypertension in connective tissue disease
2014 - 2017 Role of IPAS/HIF-3alpha-mediated signals in the pathophysiology of pulmonary hypertension associated with connective tissue disease
2012 - 2016 Elucidation of the regulatory mechanism for glucose-mediated pathogenic gene expression in diabetic nephropathy and its therapeutic application
2011 - 2013 Role of hypoxia-inducible transcription factors in regulation of immune response and its therapeutic application
2010 - 2012 マイクロRNAによるNF-κB制御を介した関節リウマチ治療戦略に関する研究
2008 - 2010 Mechanism of regulation of immune response by hypoxia-inducible factors and its therapeutic application to inflammatory diseases
2007 - 2009 Strategise for treatment of rheumatoid synovitis on the focus of IκBβ2 expression.
2006 - 2007 低酸素シグナル抑制分子IPASの発現制御法の開発とがん治療への応用
2005 - 2006 Development of a novel therapy targeting the hypoxia response system in the immune cells for inflammatory diseases.
2005 - 2005 HIF-1拮抗分子IPASの発現制御機構の解明と抗血管新生療法開発への応用
2002 - 2005 低酸素シグナルによる生体機能調節機構の解明と疾患治療への応用
2002 - 2005 Signal transduction in hypoxic cells, biological consequence and therapeutic exploit
2004 - 2004 低酸素誘導性転写因子群を標的とする新規抗血管新生療法開発に関する研究
2003 - 2004 低酸素シグナルによるリンパ球機能制御機構の解明
2003 - 2004 低酸素応答性選択的スプライシング機構の解明と生体機能調節
2003 - 2003 HIF-1抑制分子IPAS遺伝子の発現調節機構の解明
2002 - 2002 低酸素誘導性転写因子に拮抗する新規蛋白IPASのがん増殖、進展における役割
2000 - 2001 Research on development of novel pharmacological strategy for antiinflammatory drugs targeting the glucocorticoid receptor
2000 - 2001 慢性関節リウマチの分子病態の解明と治療法開発に関する研究
核内受容体の機能制御機構の解明に関する研究
酸素分圧による遺伝子発現調節機構の解明に関する研究
Study on regulatory mechanism of nuclear receptor function
Study on gene regulation by oxygen tension
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Papers (24)：
Tomoki Kawahata, Kitaru Tanaka, Kyohei Oyama, Jun Ueda, Kensaku Okamoto, Yuichi Makino. HIF3A gene disruption causes abnormal alveoli structure and early neonatal death. PloS one. 2024. 19. 5. e0300751
- 1996 Asahikawa Medical College Graduate School, Division of Medicine
- 1992 Asahikawa Medical University School of Medicine Medical Course
- 1992 Asahikawa Medical College Faculty of Medicine
Professional career (1)：
-
Work history (6)：
2011/10 - 2019/05 Asahikawa Medical University Division of Metabolism and Biosystemic Sience、Department of Medicine Associate Professor
2007/07 - 2011/09 Asahikawa Medical University Division of Metabolism and Biosystemic Sience, Department of Medicine Lecturer
2004/04 - 2006/06 Institute of Medical Science, University of Tokyo Hospital The Institute of Medical Science Research Hospital Department of Rheumatology and Allergy assistant professor
