Kubo Shuji

クボシュウジ | Kubo Shuji

Affiliation and department：
Job title： Laboratory head
Other affiliations (2)：

Research field (3)： Fetal medicine/Pediatrics , Virology , Medical biochemistry

Research keywords (6)： Cancer virotherapy , 細胞治療 , 遺伝子治療 , Viral vectors , Cell therapy , Gene therapy

Research theme for competitive and other funds (21)：

2023 - 2026 脳梗塞後の組織修復・再生における脳傷害/虚血誘導性幹細胞による老廃物除去の役割
2021 - 2025 播種性癌に対する革新的な自殺遺伝子ウイルス療法の開発
2019 - 2022 Development of virotherapy for osteosarcoma pulmonary metastases using stem cells as carriers
2018 - 2021 Development of cell transplantation therapy using human injury/ischemia-induced neural stem/progenitor cells
2016 - 2019 Development of retroviral replicating vector-mediated suicide gene therapy for malignant mesothelioma

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Papers (68)：

Shuichi Fujiwara, Akiko Nakano-Doi, Toshinori Sawano, Shuji Kubo, Nobutaka Doe, Takayuki Nakagomi. Administration of Human-Derived Mesenchymal Stem Cells Activates Locally Stimulated Endogenous Neural Progenitors and Reduces Neurological Dysfunction in Mice after Ischemic Stroke. Cells. 2024. 13. 11
Emiko Sonoda-Fukuda, Yuya Takeuchi, Nao Ogawa, Shunsuke Noguchi, Toru Takarada, Noriyuki Kasahara, Shuji Kubo. Targeted Suicide Gene Therapy with Retroviral Replicating Vectors for Experimental Canine Cancers. International Journal of Molecular Sciences. 2024. 25. 5. 2657-2657
Lisa Isoda, Emiko Sonoda-Fukuda, Hiroaki Fujino, Toru Takarada, Kosei Hasegawa, Noriyuki Kasahara, Shuji Kubo. Therapeutic Efficacy of Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors for Human Ovarian Cancer. Anticancer research. 2023. 43. 12. 5311-5317
平野佳伸, 中込隆之, 土居亜紀子, 久保秀司, 湊雄介, 澤野俊憲, 都築建三, 阪上雅史. ミクログリアがマウス脳梗塞巣由来傷害/虚血誘発性神経幹細胞に及ぼす影響. 脳循環代謝. 2023. 35. 1. 116-116
Hiroaki Fujino, Emiko Sonoda-Fukuda, Lisa Isoda, Ayane Kawabe, Toru Takarada, Noriyuki Kasahara, Shuji Kubo. Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model. International journal of molecular sciences. 2023. 24. 19

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MISC (37)：

S. Kubo, M. Takagi-Kimura, N. Kasahara. Retroviral replicating vector-mediated prodrug activator gene therapy in an experimental model of human osteosarcoma. HUMAN GENE THERAPY. 2017. 28. 12. A28-A29
Masatoshi Tagawa, Thao T. T. Nguyen, Takao Morinaga, Boya Zhong, Michiko Hanazono, Shuji Kubo, Masato Shingyoji, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, et al. An Inhibitor for the MDM2-p53 Interaction Produces Synergistic Cytotoxicity with Oncolytic Adenoviruses on Mesothelioma with Wild-Type p53 Genotype. MOLECULAR THERAPY. 2017. 25. 5. 280-280
Shuji Kubo, Misato Takagi-Kimura, Noriyuki Kasahara. Prodrug Activator Gene Therapy Using Retroviral Replicating Vectors in an Experimental Model of Human Osteosarcoma. MOLECULAR THERAPY. 2017. 25. 5. 61-61
Y. Tada, T. T. Nguyen, S. Kubo, M. Shingyoji, I. Sekine, K. Tatsumi, H. Shimada, K. Hiroshima, M. Tagawa. E1B-55kDa-defective adenoviruses produced cytotoxicity in combination with MDM2 inhibitors on INK4A/ARF-defective mesothelioma. HUMAN GENE THERAPY. 2016. 27. 11. A89-A89
S. Kubo, Y. Mawatari-Furukawa, N. Kasahara. Customization of virotherapy with retroviral replicating vectors on the basis of cellular receptor expression profiles. HUMAN GENE THERAPY. 2016. 27. 11. A82-A82

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Education (2)：

Professional career (1)：

Association Membership(s) (7)：

日本癌学会 , 日本分子生物学会 , 日本人類遺伝学会 , 日本小児科学会 , 日本遺伝子細胞治療学会 , 米国遺伝子細胞治療学会 , 欧州遺伝子細胞治療学会

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