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J-GLOBAL ID：200901083915352120   Update date: Apr. 10, 2024

Keiji Miyazawa

ミヤザワ ケイジ | Keiji Miyazawa
Affiliation and department：
University of Yamanashi Graduate Faculty of Interdisciplinary Research Faculty of Medicine, Basic Science for Clinical Medicine (Biochemistry 2)

About University of Yamanashi Graduate Faculty of Interdisciplinary Research Faculty of Medicine, Basic Science for Clinical Medicine (Biochemistry 2)


Job title： Professor
Homepage URL  (1)： http://www.med.yamanashi.ac.jp/basic/bioche02/bioch2.html
Research field  (5)： Pharmaceuticals - health and biochemistry ,  Tumor biology ,  Pathobiochemistry ,  Medical biochemistry ,  Functional biochemistry
Research theme for competitive and other funds  (23)：
  • 2021 - 2025 EMT関連形質を個別に誘導するTGF-βシグナル分岐経路の解析
  • 2020 - 2023 Comprehensive Studies on the Mechanisms of Cancer Metastasis from Molecular Signaling to Whole-Body Level
  • 2017 - 2020 Smad転写複合体のheterogeneityを識別する手法の開発
  • 2016 - 2019 がん悪性化に関与するSmad cofactorの同定と機能解析
  • 2011 - 2014 Studies on a role of TGF-beta mimetic activity of HCV NS3 protease in pathogenesis of liver cirrhosis
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Papers (130)：
  • Motizuki M, Yokoyama T, Saitoh M, Miyazawa K. The Snail signaling branch downstream of the TGF-β/Smad3 pathway mediates Rho activation and subsequent stress fiber formation. 2024. 300. 1. 105580
  • Itoh Y, Sawaguchi T, Fu H, Omata C, Saitoh M, Miyazawa K. Indole-derived compound SIS3 targets a subset of activated Smad complexes. JOURNAL OF BIOCHEMISTRY. 2023. 173. 283-291
  • Yokoyama T, Kuga T, Itoh Y, Otake S, Omata C, Saitoh M, Miyazawa K. Smad2Δexon3 and Smad3 have distinct properties in signal transmission leading to TGF-β-induced cell motility. JOURNAL OF BIOLOGICAL CHEMISTRY. 2023. 299. 2. 102820-102820
  • Ichikawa MK, Endo K, Itoh Y, Osada AH, Kimura Y, Ueki K, Yoshizawa K, Miyazawa K, Saitoh M. Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells. FEBS Open Bio. 2022. 12. 7. 1353-1364
  • Tomohiro Ogami, Yusuke Tamura, Kim Toss, Keiko Yuki, Masato Morikawa, Shuichi Tsutsumi, Hiroyuki Aburatani, Keiji Miyazawa, Kohei Miyazono, Daizo Koinuma. MAB21L4 regulates the TGF-β-induced expression of target genes in epidermal keratinocytes. Journal of biochemistry. 2021
ｍore...
MISC (16)：
  • Miyazawa K, Itoh Y, Fu H, Miyazono K. Receptor-activated transcription factors and beyond: multiple modes of Smad2/3-dependent transmission of TGF-β signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2024. 300. 107256
  • Yan X, Zhang L, Miyazawa K, Ten Dijke P. TGF- β and BMP signaling in cancer. Frontiers in Cell and Developmental Biology. 2022. 10. 1012326
  • Yuka Itoh, Masao Saitoh, Keiji Miyazawa. Smad3-STAT3 crosstalk in pathophysiological contexts. Acta Biochimica et Biophysica Sinica. 2018. 50. 1. 82-90
  • Keiji Miyazawa, Kohei Miyazono. Regulation of TGF-beta Family Signaling by Inhibitory Smads. COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2017. 9. 3. a022095
  • Akira Hayakawa, Masao Saitoh, Keiji Miyazawa. Dual roles for epithelial splicing regulatory proteins 1 (ESRP1) and 2 (ESRP2) in cancer progression. Advances in Experimental Medicine and Biology. 2017. 925. 33-40
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Books (18)：
  • 分子細胞生物学(第9版)
    2023
  • 薬と生命を学人のための基礎生化学
    化学同人 2023 ISBN:9784759821666
  • 臨床生化学(第6版)
    メディカ出版 2023 ISBN:9784840478328
  • ミースフェルド 生化学
    東京化学同人 2020
  • 進化するがん創薬
    化学同人 2019
ｍore...
Education (2)：
  • - 1988 The University of Tokyo 薬学系研究科
  • - 1983 The University of Tokyo 薬学部 薬学科
Professional career (1)：
  • 薬学博士 (東京大学)
Work history (7)：
  • 2009/04/01 - 山梨大学 大学院総合研究部(医学域) 生化学講座 教授
  • 2007/04/01 - 2009/03/31 東京大学 大学院医学系研究科 分子病理 准教授
  • 2001/04/01 - 2007/03/31 東京大学 大学院医学系研究科 分子病理 助教授
  • 1997/08/01 - 2001/03/31 東京工業大学 生命理工学部 助教授
  • 1995/04/01 - 1997/07/31 Ludwig Institute for Cancer Research Uppsala Branch (SWEDEN) 研究員
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