Masato Fujioka

フジオカマサト | Masato Fujioka

Affiliation and department：
Job title： Professor
Other affiliations (1)：

Kitasato University Hospital

Research field (10)： Evolutionary biology , Cognitive neuroscience , Basic brain sciences , Genomics , Developmental biology , Genetics , Laboratory animal science , Molecular biology , Otorhinolaryngology , Immunology

Research keywords (13)： Clinical trial, Regulatory affairs , Molecular Genetics , Translational Research , Clinical Genetics , central auditory pathway , iPSC based drug discovery , DTT , inner ear regeneration , autoimmune hearing loss , hearing loss , Meniere disease , endoscopic ear surgery , MRI

Research theme for competitive and other funds (28)：

2024 - 2027 多層臨床データの情報数理解析と幹細胞医学・発生工学の融合による加齢性難聴研究
2022 - 2025 Integrated understanding of the brain network: from auditory perception
2021 - 2024 IoTセンシングとiPS細胞研究の融合による内耳障害の統合的理解と次世代型創薬
2021 - 2024 分子生体制御学的・行動解析学的アプローチによる内耳性難聴の発症メカニズムの解明
2020 - 2022 A precision Medicine for acute sensorineural hearing loss

2019 - 2022 多層オミックスとiPS技術,霊長類モデルを駆使した加齢性難聴への挑戦

2018 - 2022 Biochemical and behavioral approach against inner ear disorder and development of new therapeutic modality

2018 - 2022 Construction of a mouse model for Auditory Neuropathy Spectrum Disorder

2018 - 2021 Development of novel therapeutics for autoimmune inner ear disorder by using new transgenic mouse model

2018 - 2021 Development of novel therapeutics for the cochlear hearing impairments by using hiPSCs and common marmoset models

2017 - 2020 AR-navigated transcanal endoscopic inner ear sugery

2017 - 2019 Modeling inner ear cilliopathy using patient derived iPS cells

2016 - 2019 Endoplasmic stress response in cochlear culture

2016 - 2019 Regulation of hair cell microstructure and auditory function by Hippo pathway

2016 - 2019 Establishment of selective outer hair cell differentiation induction method from human iPS cells and research of deafness by diseased iPS cells.

2015 - 2019 analysis of inner ear drug delivery system

2015 - 2018 Immunobiology in the cochlea: an analyses with a novel autoimmune transgenic mouse

2015 - 2018 Clarification of Pendred syndrome Goiter with iPS Cells Derived from the Patients

2015 - 2018 In vitro "virtual biopsy" of cochlear cells by using Wolfram syndrome patients derived hiPSCs

2015 - 2018 ヒトiPS細胞と小型霊長類コモンマーモセットを用いた蝸牛有毛細胞再生の前臨床検討

2015 - 2017 Homeostasis with Inner Ear Specific Autophagy Deficit Model Mice

2014 - 2017 Drug screening and development using hES/iPSC-derived otic progenitor

2012 - 2016 A primate model for hearing research using non-human primate common marmoset

2012 - 2015 Exploring novel therapeutic targets by using a newly generated autoimmune hearing loss transgenic mouse model

2012 - 2014 New analysis of inner ear pharmacology

2010 - 2011 Morphological analyses of Common Marmoset(Callithrix jacchus) cochlea and temporal bone for future translational researches

2010 - 2011 Mouse models of Autoimmune hearing loss generated by a transgenic approach and its implication

2005 - 2006 内耳炎症メカニズムの解明と急性感音難聴に対するサイトカイン阻害療法の検討

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Papers (343)：

Chika Saegusa, Hideki Mutai, Tsubasa Saeki, Saeko Matsuzaki, Akifumi Mizukoshi, Shin-Ichiro Kitajiri, Tatsuo Matsunaga, Makoto Hosoya, Hideyuki Okano, Masato Fujioka. Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene. Stem cell research. 2024. 79. 103489-103489
Yusuke Masano, Chika Saegusa, Mitsuru Ishikawa, Tatsuo Matsunaga, Hideyuki Okano, Masato Fujioka. Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA. Stem cell research. 2024. 78. 103452-103452
Ryota Tamura, Yoshiharu Yamanobe, Masato Fujioka, Yukina Morimoto, Mariko Fukumura, Masato Nakaya, Yumiko Oishi, Mizuto Sato, Ryo Ueda, Hirokazu Fujiwara, et al. Phase I/II Study of a Vascular Endothelial Growth Factor Receptor Vaccine in Patients With NF2-Related Schwannomatosis. Journal of Clinical Oncology. 2024
Satoshi Suda, Mitsuru Kitamura, Miho Kawaida, Masato Fujioka, Hiroyuki Ozawa. A Case Report of a Middle Ear Mass Originated From Cartilage-like Tissue Treated With Transcanal Endoscopic Ear Surgery. Ear, Nose & Throat Journal. 2024
Yuta Kurashina, Kurihara S, Kubota T, Takatsuka S, Hirabayashi M, Shinmura H, Miyahara H, Hioki A, Matsushita Y, Muramatsu J, et al. Adeno-Associated Virus-Encapsulated Alginate Microspheres Loaded in Collagen Gel Carriers for Localized Gene Transfer. Advanced healthcare materials. 2024

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MISC (80)：

Tamura R, Fujioka M, Morimoto Y, Ohara K, Kosugi K, Oishi Y, Sato M, Ueda R, Fujiwara H, Hikichi T, et al. Author Correction: A VEGF receptor vaccine demonstrates preliminary efficacy in neurofibromatosis type 2 (Nature Communications, (2019), 10, 1, (5758), 10.1038/s41467-019-13640-1). Nature Communications. 2020. 11. 1. 2028-2028
野口勝, 藤岡正人, 忰田かおり, 北村充, 堀明美, 薬師丸令子, 粕谷健人, 西山崇経, 石川徹, 細谷誠, et al. 高齢者の聴覚と暮らし方と健康に関する学術調査(第2報) GWASによる老人性難聴関連遺伝子多型の探索. Audiology Japan. 2019. 62. 5. 435-435
忰田かおり, 藤岡正人, 北村充, 堀明美, 薬師丸令子, 野口勝, 粕谷健人, 西山崇経, 石川徹, 細谷誠, et al. 高齢者の聴覚と暮らし方と健康に関する学術調査(第2報) 老人性難聴のリスクファクターの探索. Audiology Japan. 2019. 62. 5. 568-568
栗原渉, 藤岡正人, 平林源希, 小川郁, 山本裕, 小島博己. 小型霊長類コモンマーモセット側頭骨の解剖学的解析による内耳薬剤投与経路の検討. 日本耳鼻咽喉科学会会報. 2019. 122. 4. 624-624
山野邉義晴, 藤岡正人, 西山崇経, 野口勝, 鈴木成尚, 細谷誠, 矢部はる奈, 吉浜圭祐, 勝沼紗矢香, 鈴木法臣, et al. 自宅連日検査によるペンドレッド症候群の聴力変化の記録とその解析検討. 日本耳鼻咽喉科学会会報. 2019. 122. 4. 622-622

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Patents (13)：

内耳有毛細胞の製造方法、薬剤の評価方法、及び細胞分化誘導用組成物
内耳前駆細胞の製造方法、内耳有毛細胞の製造方法、薬剤の評価方法、及び内耳細胞分化誘導用組成物
聴覚喪失治療
頭位動揺測定装置、頭位動揺測定方法、及び、それを用いた生体情報取得システム
薬物送達用担体

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Education (2)：

2006 - Keio University Graduate School, Division of Medicine Otorhinolaryngology
2002 - Keio University Faculty of Medicine 医学科

Professional career (2)：

MD, PhD
MD (Keio University)

Work history (15)：

2024/07 - 現在 Kitasato University Faculty of Medicine Director
2024/05 - 現在北里大学病院臨床研究推進センター臨床企画推進部門
2022/04 - 現在 Kitasato University Hospital
2022/02 - 現在 Kitasato University Graduate School of Medical Sciences
2022/02 - 現在 Keio University

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Committee career (5)：

2022/09 - 現在日本耳科学会代議員
2022/06 - 現在 Frontiers Review Editor on the Editorial Board
2022 - 現在北里医学評議員
2020 - 現在 Auris Nasus Larynx Review Board
2020 - 2022/10 日本聴覚医学会代議員

Awards (8)：

2020/09 - 日本医師会医学研究奨励賞
2020/06 - 慶應義塾大学医学部三四会三四会北島賞
2019/10 - 日本耳科学会第2回日本耳科学会賞
2019/06 - 耳鼻咽喉科臨床学会第81回優秀ポスター賞
2019/03 - 東京都 Blockbuster TOKYO Beyond Next Ventures 賞

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Association Membership(s) (16)：

The international Otopathology society (a.k.a. The Schuknecht Society) , International Society for Stem Cell Research , Association for Researchers in Otolaryngology , 日本マーモセット研究会 , 日本炎症再生医学会 , 日本神経科学学会 , 日本臨床遺伝学会 , 日本再生医療学会 , 日本アレルギー学会 , 耳鼻咽喉科短期滞在手術研究会 , 耳鼻咽喉科臨床学会 , 日本小児耳鼻咽喉科学会 , 日本めまい平衡医学会 , 日本聴覚医学会 , 日本耳科学会 , 日本耳鼻咽喉科学会

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