Ishida Takumi

イシダタクミ | Ishida Takumi

Affiliation and department：
Job title：教授

Research field (5)： Pharmaceuticals - health and biochemistry , Food sciences , Hygiene and public health (non-laboratory) , Hygiene and public health (laboratory) , Environmental effects of chemicals

Research keywords (8)： aryl hydrocarbon receptor , zinc homeostasis , zinc transporter , transcriptional regulation , oxidative stress , dioxins , selenium-binding protein , Molecular Toxicology

Research theme for competitive and other funds (10)：

2012 - 2015 Pathogenic mechanism of metabolic syndrome by glycation intermediates, and its sensitive diagnostic method
2011 - 2013 The involvement of dihydropyrazine-induced gene damage in diabetic complication
2009 - 2010 The study of toxic mechanisms of dioxins using selenium-binding protein deficient mouse.
2007 - 2009 Dioxin-induced imprinting of sexual immaturity and its mechanism
2006 - 2007 熱ショックタンパク質による芳香族炭化水素レセプター転写活性化制御の可能性

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Papers (60)：

Jian-Rong Zhou, Shigenori Kinno, Kenta Kaihara, Madoka Sawai, Takumi Ishida, Shinji Takechi, Jun Fang, Toshihiro Nohara, Kazumi Yokomizo. Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling. Nutrients. 2024. 16. 11. 1699
Madoka Sawai, Yuu Miyauchi, Takumi Ishida, Shinji Takechi. Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of Toxicological Sciences. 2022. 47. 9. 381-387
Yuu Miyauchi, Madoka Sawai, Takumi Ishida, Hisao Kansui, Shinji Takechi. Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products. The Journal of Toxicological Sciences. 2021. 46. 11. 509-514
Yingxia Song, Atsushi Kurose, Renshi Li, Tomoki Takeda, Yuko Onomura, Takayuki Koga, Junpei Mutoh, Takumi Ishida, Yoshitaka Tanaka, Yuji Ishii. Ablation of Selenbp1 Alters Lipid Metabolism via the Pparα Pathway in Mouse Kidney. International Journal of Molecular Sciences. 2021. 22. 10. 5334-5334
Madoka Esaki, Takumi Ishida, Yuu Miyauchi, Shinji Takechi. The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. The Journal of Toxicological Sciences. 2020. 45. 7. 401-409

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MISC (26)：

古賀貴之, 廣村信, 平尾雅代, 竹田修三, 石田卓已, 石井祐次, 小武家優子, 戸田晶久, 副田二三夫. Hepatic Bhmt regulates suppressive effect of methionine on chemical-induced dermatitis. 日本薬学会年会要旨集(Web). 2022. 142nd
古賀貴之, 廣村信, SONG Yingxia, 石井祐次, 平尾雅代, 竹田修三, 石田卓已, 小武家優子, 戸田晶久, 副田二三夫. Selenium binding protein 1 regulates suppressive effect of methionine on chemical-induced dermatitis. 衛生薬学・環境トキシコロジー講演要旨集. 2021. 2021
古賀貴之, 立川怜那, 廣村信, 香川正太, 石井祐次, 平尾雅代, 竹田修三, 石田卓已, 長島史裕, 小武家優子, et al. Selenium binding protein1(Selenbp1)欠損が高脂肪食誘発性脂肪肝へ及ぼす影響の解析. 日本薬学会九州支部大会講演要旨集. 2021. 38th (CD-ROM)
古賀貴之, 廣村信, SONG Yingxia, 武田知起, 石井祐次, 石田卓已, 小武家優子, 副田二三夫, 戸田晶久. Selenium binding protein 1 (Selenbp1) modulates chemical-induced dermatitis. 衛生薬学・環境トキシコロジー講演要旨集. 2020. 2020
SONG Yingxia, 黒瀬厚, LI Ren-shi, 武田知起, 小野村優子, 古賀貴之, 石田卓已, 田中嘉孝, 石井祐次. Ablation of selenium binding protein 1 (Selenbp1) alters lipid metabolism and oxidative stress. 衛生薬学・環境トキシコロジー講演要旨集. 2020. 2020

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Books (2)：

Bioassay and bio-informatics : for environmental assessment and medicinal sciences
Kougaku-Tosho, Publishers 2011 ISBN:9784769204954
油症研究 II 治療と研究の最前線
九州大学出版会 2010 ISBN:9784798500072

Lectures and oral presentations (149)：

Selenium-binding protein (SelenBP)1/2 modulate hepatic lipid metabolism through PPARa: Study using SelenBP1/2-double knockout mice
(The 144 Annual Meeting of the Pharmaceutical Society of Japan 2024)
果糖過剰摂取による脂肪肝形成の性差への Selenium binding protein 1 (Selenbp1) 欠損の影響
(第40回日本薬学会九州山口支部大会 2023)
The contribution of Selenium binding protein 1 (Selenbp1) to the regulation of hepatic methionine metabolizing enzyme Bhmt expression based on skin-liver interaction by allergic contact dermatitis
(Forum 2023 : Pharmaceutical Health Sciences • Environmental Toxicology 2023)
Dihydropyrazine regulates the TLR4 negative feedback mechanism
(Form 2022 : Pharmaceutical Health Sciences • Environmental Toxicology 2022)
Dihydropyrazines induce endoplasmic reticulum stress and inhibit autophagy in human hepatoma HepG2 cells
(Form 2022 : Pharmaceutical Health Sciences • Environmental Toxicology 2022)

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Education (2)：

1994 - 1997 Kyushu University
1990 - 1994 Kyushu University School of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (九州大学)

Work history (6)：

2020 - 現在 International University of Health and Welfare School of Pharmacy at Fukuoka Professor
2010 - 2020 Sojo University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences Associate Professor
2000 - 2010 Kyushu University Graduate School of Pharmaceutical Sciences Assistant Professor
1999 - 2000 Kyushu University Graduate School of Pharmaceutical Sciences Assistant Professor
1997 - 1999 Kyushu University School of Pharmaceutical Sciences Assistant Professor

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Awards (5)：

2011 - 日本毒性学会 2011年度田邉賞
2008/12 - 第25回日本薬学会九州支部大会物理・環境系優秀発表賞
2008 - 日本薬学会 Journal of Health Science Best Paper Award 2008
2005/12 - 第22回日本薬学会九州支部大会物理・環境系優秀発表賞
2004/12 - 第21回日本薬学会九州支部大会物理・環境系優秀発表賞

Association Membership(s) (2)：

The Japanese Biochemical Society , The Pharmaceutical Society of Japan

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