Shinya Kazuo

Affiliation and department：
Job title： Group Leader
Homepage URL (1)： http://www.aist.go.jp/RESEARCHERDB/cgi-bin/worker_detail.cgi?call=namae&rw_id=K49954079

Research field (1)： Applied microbiology

Research theme for competitive and other funds (18)：

2023 - 2028 Studies on innovative technology for modification of structural skeleton of natural products and production of artificial novel natural compounds
2020 - 2024 メタゲノミクスによる海綿における天然有機化合物生産機構の解明
2019 - 2023 Fermentative production of rare natural compounds found in marine organisms living in the seas of Thailand
2014 - 2019 Development of novel methods for target identification of natural products and chemical epigenetics
2011 - 2014 Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.

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Papers (178)：

Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-Ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie (International ed. in English). 2024. e202317805
Shiina Suzuki, Shun Saito, Yuki Narushima, Shunta Kodani, Noritaka Kagaya, Hikaru Suenaga, Kazuo Shin-ya, Midori A. Arai. Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation. The Journal of Antibiotics. 2023
Kuga Arima, Satoko Akiyama, Kazuo Shin-ya, Kenichi Matsuda, Toshiyuki Wakimoto. Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis. Angewandte Chemie International Edition. 2023
Fumitaka Kudo, Kosuke Kishikawa, Kazuma Tsuboi, Takafusa Kido, Takeo Usui, Junko Hashimoto, Kazuo Shin-Ya, Akimasa Miyanaga, Tadashi Eguchi. Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics. Chembiochem : a European journal of chemical biology. 2023. 24. 6. e202200670
Fumitaka Kudo, Atsushi Minato, Shusuke Sato, Nayuta Nagano, Chitose Maruyama, Yoshimitsu Hamano, Junko Hashimoto, Ikuko Kozone, Kazuo Shin-Ya, Tadashi Eguchi. Mechanism of S-Adenosyl-l-methionine C-Methylation by Cobalamin-dependent Radical S-Adenosyl-l-methionine Methylase in 1-Amino-2-methylcyclopropanecarboxylic Acid Biosynthesis. Organic letters. 2022

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MISC (17)：

小田忍, 中川愛美, 野村聖也, 新家一男, 加賀谷紀貴, 河原哲平, 大箸信一. 固/液界面培養による生物活性物質生産カビ,放線菌のスクリーニング. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
Kenichi Matsuda, Fumihito Hasebe, Takeo Tomita, Yu Shiwa, Hirofumi Yoshikawa, Kazuo Shin-ya, Tomohisa Kuzuyama, Makoto Nishiyama. Screening of secondary metabolites biosynthesized with novel amino acid carrier protein system. FASEB JOURNAL. 2014. 28. 1
小林正弥, 尾崎太郎, 新家一男, 西山真, 葛山智人. 放線菌由来プレニルカルバゾール類縁体生合成遺伝子の同定. 日本ゲノム微生物学会年会要旨集. 2014. 8th
小林正弥, 尾崎太郎, 新家一男, 西山真, 葛山智久. 放線菌の生産するプレニルインドールアルカロイドの生合成. 日本放線菌学会大会講演要旨集. 2014. 29th
小林正弥, 尾崎太郎, 新家一男, 西山真, 葛山智久. 放線菌の生産するプレニルカルバゾール類縁体の生合成研究. 日本農芸化学会大会講演要旨集(Web). 2014. 2014

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Education (3)：

1990 - 1993 東京大学大学院農学系研究科農芸化学専攻博士課程
1988 - 1990 東京大学大学院農学系研究科農芸化学専攻修士課程
1984 - 1988 東京農工大学卒業

Professional career (1)：

博士 (農学)

Work history (3)：

2020/04 - 現在 National Institute of Advanced Industrial Science and Technology Leading-edge biotechnology research group Department of Life Science and Biotechnology Biotechnology, Cellular and Molecular Biotechnology Research Institute Group Leader
2006/10 - 2020/03 National Institute of Advanced Industrial Science and Technology
1993/04 - 2006/09 The University of Tokyo Institute of Molecular and Cellular Biosciences

Association Membership(s) (4)：

日本神経化学会 , 日本癌分子標的治療学会 , 日本癌学会 , 日本農芸化学会

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