Rchr
J-GLOBAL ID：200901085421585753   Update date: Dec. 18, 2024

Shinkai Yoichi

シンカイ ヨウイチ | Shinkai Yoichi
Affiliation and department：
RIKEN Cellular Memory Laboratory, Cluster for Pioneering Research

About RIKEN Cellular Memory Laboratory, Cluster for Pioneering Research


Job title： Chief Scientist
Homepage URL  (1)： http://shinkai.riken.jp/
Research field  (5)： Genetics ,  Genomics ,  Cell biology ,  Molecular biology ,  Functional biochemistry
Research keywords  (13)： transcriptional regulation ,  heterochromatin ,  protein post-translational modification ,  epigenetics ,  クロマチン ,  染色体 ,  ヒストン ,  メチル化酵素 ,  Chromatin ,  Chromosome ,  Telomere ,  Histone ,  Methyltransferase
Research theme for competitive and other funds  (25)：
  • 2024 - 2027 Deciphering of the transposable elements enhancing cardiac myocyte proliferation to overcome heart failure
  • 2022 - 2025 Elucidation of molecular mechanism of heterochromatin formation and maintenance
  • 2018 - 2023 Oviduct as the site of fertilization and early embryonic development: Verification of its physiological functions using genetically engineering hamster model for clinical application
  • 2018 - 2023 細胞分化にともなうクロマチンポテンシャルの変化とその分子基盤
  • 2018 - 2022 ヒストンH3K9メチル化修飾による転写抑制の包括的理解
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Papers (125)：
  • Motoi Yamashita, Chihiro Ogawa, Baihao Zhang, Tetsuro Kobayashi, Aneela Nomura, Clive Barker, Chengcheng Zou, Satoshi Yamanaka, Ken-Ichiro Hayashi, Yoichi Shinkai, et al. Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems. Nature communications. 2024. 15. 1. 10129-10129
  • Akeo Shinkai, Hideharu Hashimoto, Chikako Shimura, Hiroaki Fujimoto, Kei Fukuda, Naoki Horikoshi, Masaki Okano, Hitoshi Niwa, Erik W Debler, Hitoshi Kurumizaka, et al. The C-terminal 4CXXC-type zinc finger domain of CDCA7 recognizes hemimethylated DNA and modulates activities of chromatin remodeling enzyme HELLS. Nucleic acids research. 2024
  • Hisashi Ideno, Kazuhisa Nakashima, Koichiro Komatsu, Hiroshi Kimura, Yoichi Shinkai, Makoto Tachibana, Akira Nifuji. Epigenetic modifier G9a is involved in regulation of mouse tongue development. Journal of oral biosciences. 2024. 66. 1. 35-40
  • Tadahiro Shimazu, Rei Yoshimoto, Kaoru Kotoshiba, Takehiro Suzuki, Shogo Matoba, Michiko Hirose, Mai Akakabe, Yoshihiro Sohtome, Mikiko Sodeoka, Atsuo Ogura, et al. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes & Development. 2023
  • Kei Fukuda, Takeshi Shimi, Chikako Shimura, Takao Ono, Takehiro Suzuki, Kenta Onoue, Satoko Okayama, Hisashi Miura, Ichiro Hiratani, Kazuho Ikeda, et al. Epigenetic plasticity safeguards heterochromatin configuration in mammals. Nucleic Acids Research. 2023
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MISC (167)：
  • 福田 渓, 志村 知古, 志見 剛, 木村 宏, 眞貝 洋一. 転写促進と抑制-表と裏から理解する遺伝子発現制御 ヘテロクロマチンの核内空間制御におけるクロマチン修飾の役割. 日本生化学会大会プログラム・講演要旨集. 2022. 95th. 2S16e-06
  • TAKEMOTO Keiko. Mechanism for endogenous retrovirus silencing and innate immune responses. 2018
  • Takuma Nakatsuka, Keisuke Tateishi, Hiroyuki Kato, Hiroaki Fujiwara, Keisuke Yamamoto, Yotaro Kudo, Yasuo Tanaka, Hideaki Ijichi, Yoichi Shinkai, Kazuhiko Koike. Histone Methyltransferase G9a Promotes Hepatocarcinogenesis By Regulating p53 Transactivity during DNA Damage Response. HEPATOLOGY. 2018. 68. 1248A-1248A
  • Shabeesh Balan, Yoshimi Iwayama, Mikiko Fukuda, Atsuko Shirai, Kaoru Kotoshiba, Motoko Maekawa, Tomoko Toyota, Tetsuo Ohnishi, Manabu Toyoshima, Yoichi Shinkai, et al. Targeted re-sequencing of genes involved in H3K9 methylation machinery in autism spectrum disorders reveal a loss of function variant in SUV39H2. HUMAN GENOMICS. 2018. 12
  • Keiko Takemoto, Masaki Kato, Yoichi Shinkai. Mechinism for endogenous retrovirus silencing in MEF by histone methyltransferase Setdb1. Annual meeting of the Molecular Biology. 2017
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Education (3)：
  • 1986 - 1990 Juntendo University Graduate School of Medicine Immunology
  • 1984 - 1986 Tsukuba University Master course Medical Science
  • 1980 - 1984 Yamagata University Faculty of Science Department of Biology
Professional career (2)：
  • Doctor of Medicine (Juntendo University)
  • Master of Medical Science (University of Tsukuba)
Work history (11)：
  • 2015/04 - 現在 RIKEN Cellular memory laboratory Chief Scientist
  • 2012/04 - 2015/03 RIKEN Cellular memory laboratory Chief Scientist
  • 2011/04 - 2012/03 RIKEN Cellular memory laboratory, Advanced Science Institute Visiting Chief Scientist
  • 2003/07 - 2012/03 Kyoto University Institute for Virus Research Professor
  • 1998/06 - 2003/06 Kyoto University Institute for Virus Research Associate Professor
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Association Membership(s) (3)：
The Japanese Society for Epigenetics ,  日本生化学会 ,  日本分子生物学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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