KANNA MACHI

カンナマチ | KANNA MACHI

Affiliation and department：
Job title： Assistant professor

Research field (1)： Medical biochemistry

Research theme for competitive and other funds (6)：

2023 - 2026 Hippo/YAP経路へのPin1作用と肝や脂肪組織の肥大、炎症、線維化への関与
2022 - 2025 NASHの炎症、線維化におけるPin1の役割解明と臨床応用への展開
2020 - 2023 栄養状態に依存する筋肉機能制御と代謝異常におけるプロリン異性化酵素Pin1の役割
2016 - 2018 Realization of high ethanol production from lignocellulosic biomass
2013 - 2018 Liquid phase simultaneous saccharification and fermentation process using hydrothermal dissolution of cellulose

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Papers (35)：

Takeshi Yamamotoya, Yukino Ohata, Yasuyuki Akasaka, Shun Hasei, Masa-Ki Inoue, Yusuke Nakatsu, Machi Kanna, Hiroki Yamazaki, Akifumi Kushiyama, Midori Fujishiro, et al. Trk-fused gene plays a critical role in diet-induced adipose tissue expansion and is also involved in thyroid hormone action. PNAS nexus. 2024. 3. 4. pgae150
Yasuyuki Akasaka, Shun Hasei, Yukino Ohata, Machi Kanna, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Akio Matsubara, et al. Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells. International journal of molecular sciences. 2023. 24. 21
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Akifumi Kushiyama, Midori Fujishiro, Hideyuki Sakoda, Hiraku Ono, Koji Arihiro, Tomoichiro Asano. Hepatic Pin1 Expression, Particularly in Nuclei, Is Increased in NASH Patients in Accordance with Evidence of the Role of Pin1 in Lipid Accumulation Shown in Hepatoma Cell Lines. International journal of molecular sciences. 2023. 24. 10
Shunya Aoyama, Yuri Kido, Mayu Kanamoto, Miki Naito, Mikako Nakanishi, Machi Kanna, Takeshi Yamamotoya, Tomoichiro Asano, Yusuke Nakatsu. Prolyl isomerase Pin1 promotes extracellular matrix production in hepatic stellate cells through regulating formation of the Smad3-TAZ complex. Experimental cell research. 2023. 425. 2. 113544-113544
Mayu Kanamoto, Shunsuke Takahagi, Shunya Aoyama, Yuri Kido, Mikako Nakanishi, Miki Naito, Machi Kanna, Takeshi Yamamotoya, Akio Tanaka, Michihiro Hide, et al. The expression of prolyl isomerase Pin1 is expanded in the skin of patients with atopic dermatitis and facilitates IL-33 expression in HaCaT cells. The Journal of dermatology. 2023. 50. 4. 462-471

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MISC (6)：

Akifumi Kushiyama, Yusuke Nakatsu, Xinglong Cui, Hideyuki Sakoda, Midori Fujishiro, Haruya Ohno, Misaki Iwashita, Machi Kanna, Fusanori Nishimura, Tomoichiro Asano. Involvement of Xanthine Oxidase Pathway in Pathogenesis of Macrophage Activation. DIABETES. 2010. 59. A233-A233
熊本園子, 岩下未咲, 中津祐介, 櫛山暁史, 迫田秀之, 藤城緑, 神名麻智, 郭榮, 菊池貴子, 西村英紀, et al. 活性化マクロファージによる脂肪・肝のインスリン抵抗生誘導とARBによる抵抗性改善作用の機序に関する網羅的解析. 糖尿病. 2010. 53. Suppl.1. S-120
岩下未咲, 熊本園子, 迫田秀之, 櫛山暁史, 藤城緑, 中津祐介, 張君, 菊池貴子, 神名麻智, 西村英紀, et al. LPSによる脂肪組織インスリン抵抗性へのマクロファージの関与およびARBによるインスリン抵抗性改善作用の機序. 糖尿病. 2010. 53. Suppl.1. S-119
A Kubo, S Bathula, M Tamaoki, M Kanna, M Aono, N Nakajima, H Saji. Characterization of an ozone-sensitive ozs1 mutant of Arabidopsis thaliana. PLANT AND CELL PHYSIOLOGY. 2005. 46. S169-S169
M Aono, M Kanna, T Kawashima, A Kubo, M Tamaoki, N Nakajima, H Saji. Isolation and analysis of ozone-sensitive Arabidopsis mutants. PLANT AND CELL PHYSIOLOGY. 2003. 44. S149-S149

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