Rchr

J-GLOBAL ID：200901086021679631 Update date: Jan. 30, 2024

Hashimoto Yuuichi

Hashimoto Yuuichi

Research field (1)： Pharmacology

Research theme for competitive and other funds (8)：

2013 - 2016 Identification of Alzheimer's disease-relevant neuronal death inhibiting molecular basis and its application for drug development
2010 - 2012 Search for neuronal cell death-inhibiting drugs for Alzheimer's disease-relevant signal transduction
2006 - 2007 Estblishment of curative therapy for Alzheimer's disease with Humanin peptides
2005 - 2006 アルツハイマー病抑制因子ヒユーマニンの発癌作用の検討
2004 - 2005 Establishment of curative therapy for Alzheimer's disease with Humanin peptides

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Papers (23)：

Shinya Kusakari, Mikiro Nawa, Yuichi Hashimoto, Masaaki Matsuoka. CLSPCOL rescues Alzheimer's disease mouse models. Translational neuroscience. 2022. 13. 1. 11-19
Minoru Ishikawa, Yuichi Hashimoto. Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry. JOURNAL OF MEDICINAL CHEMISTRY. 2011. 54. 6. 1539-1554
Yuji Obata, Takako Niikura, Kohsuke Kanekura, Yuichi Hashimoto, Masaoki Kawasumi, Yoshiko Kita, Sadakazu Aiso, Masaaki Matsuoka, Ikuo Nishimoto. Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity. Journal of Neuroscience Research. 2005. 81. 5. 720-729
M Ikonen, BR Liu, Y Hashimoto, LQ Ma, KW Lee, T Niikura, Nishimoto, I, P Cohen. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein-3 regulates cell survival and apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003. 100. 22. 13042-13047
Yuichi Hashimoto, Takako Niikura, Tomohiro Chiba, Emi Tsukamoto, Hisae Kadowaki, Hideki Nishitoh, Yohichi Yamagishi, Miho Ishizaka, Marina Yamada, Mikiro Nawa, et al. The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. The Journal of pharmacology and experimental therapeutics. 2003. 306. 3. 889-902

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MISC (47)：

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Education (2)：

- 1990 Juntendo University
- 1988 National Institute of Fitness and Sports in Kanoya Faculty of Physical Education

Professional career (1)：

医学 (順天堂大学)

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