Morimoto Sachio

2017 - 2020 Role of a functional SNP of the gene coding brain serotonin synthesis rate-limiting enzyme Tph2 in dilated cardiomyopathyRole of a functional SNP of the gene coding brain serotonin synthesis rate-limiting enzyme Tph2 in dilated cardiomyopathy

2017 - 2020 拡張型心筋症における脳セロトニン合成律速酵素Tph2遺伝子機能的多型の役割

2016 - 2019 Evaluation of cardiac function for DCM and HCM knock-in model mouse during early postnatal development

2015 - 2019 Elucidation of cardiomyopathy caused by gene mutations induced environmental stresses -exhaustive mutation analysis and genome editing-genome

2016 - 2019 ノックインマウスを用いたヒト遺伝性心筋症の病態形成メカニズム解明と治療薬の検討

2015 - 2018 環境ストレスで生じた遺伝子変異による難治疾患の発症解明-網羅的解析とゲノム編集-

2013 - 2016 Role of GSK3b-mediated suppression of cardiac hypertrophy in heart failure

2012 - 2015 Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.

2013 - 2015 Role of GSK3b-mediated suppression of cardiac hypertrophy in heart failure

2011 - 2014 Pathogenic mechanism of congestive heart failure in a mouse model of dilated cardiomyopathy with brain serotonin dysfunction

2011 - 2014 Pathogenic mechanism of congestive heart failure in a mouse model of dilated cardiomyopathy with brain serotonin dysfunction

2010 - 2013 脳内セロトニン低下を伴う拡張型心筋症モデルマウスの心不全発症メカニズムの解明

2010 - 2013 Molecular mechanisms of an improvement in prognosis in the mouse model of dilated cardiomyopathy treated by inhibition of the RAA system

2011 - 2012 Fundamental study on developing heart failure treatment targeting the central nervous system.

2007 - 2009 Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T

2006 - 2009 心不全の成因と治療に関する分子生理学的研究

2008 - 2009 心筋トロポニンT遺伝子突然変異による肥大型心筋症の病態発現機構の解明

2007 - 2009 Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T

2007 - 2008 肥大型心筋症ノックインマウスの作製と解析

2005 - 2007 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

1999 - 2006 アクチンフ ィラメントの構造と動態の解析による筋収縮・調節機構の解明

2005 - 2006 トロポニン分子突然変異による遺伝性心筋症の病態発現機構の解明

2005 - 2006 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

2003 - 2005 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

2003 - 2004 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

1999 - 2001 Functional analyset of mutations in human cardiac troponin T that cause familial hypertrophic cardiomyopathy

1999 - 2000 Functional analyset of mutations in human cardiac troponin T that cause familial hypertrophic cardiomyopathy

1998 - 1999 家族性肥大型心筋症を引き起こすヒト心筋トロポニンTミュータントの生理学的機能解析

1996 - 1999 Molecular mechanism of pH sensitivity of muscle contraction : investigation using site-directed mutagenesis

1995 - 1998 Molecular mechanisms of change in Ca^<2+>-sensitivity of muscle contraction induced by pH-reduction

1995 - 1998 心筋収縮のアシドーシス感受性に対するトロポニンサブユニットの役割

1996 - 1998 Molecular mechanism of pH sensitivity of muscle contraction : investigation using site-directed mutagenesis

1993 - 1997 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1995 - 1997 Molecular mechanisms of change in Ca^<2+>-sensitivity of muscle contraction induced by pH-reduction

1995 - 1995 心筋収縮のアシドーシス感受性に対するトロポニンサブユニットの役割

1993 - 1994 血管平滑筋の収縮弛緩調節機序

1992 - 1993 血管平滑筋の収縮制御機構

1993 - 1993 血管平滑筋の収縮弛緩調節機序

1993 - 1993 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1992 - 1992 血管平滑筋の収縮弛緩調節機序

1992 - 1992 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1991 - 1991 血管平滑筋の収縮弛緩調節機序

1988 - 1989 筋収縮におけるCa2+受容タンパク質トロポニンCの作用発現機構

Investigation of pathogenic mechanisms of cardiomyopathy and development of therapeutic drugs using knock-in mouse mdels

Molecular mechanism of calcium-dependent regulation of muscle contraction