Rchr

J-GLOBAL ID：200901086280141534 Update date: Feb. 01, 2024

Morimoto Sachio

モリモトサチオ | Morimoto Sachio

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.researchgate.net/profile/Sachio_Morimoto , https://orcid.org/0000-0001-9171-3636

Research field (5)： Pharmacology , Biophysics , Clinical pharmacy , Physiology , Neuroscience - general

Research keywords (15)： Ristricted cardiomyopathy , Hypertrophic cardiomyopathy , Dilated cardiomyopathy , 心肥大の分子メカニズム , カルシウムシグナリング , 遺伝子変異 , トロポニンT , Knock-in mouse , Genetic cardiomyopathy , Moecular mechanism of cardiac hypertrophy , Calcium signaling , Knock-in mouse model , Mutation , Troponin , Inherited cardiomyopathy

Research theme for competitive and other funds (49)：

2021 - 2024 老化による心筋症変異ゲノム編集マウスの分泌小胞における全遺伝子解析
2019 - 2022 肥大型心筋症の病態形成における心筋エネルギー代謝異常の役割の解明と治療薬の検討
2019 - 2022 肥大型心筋症の病態形成における心筋エネルギー代謝異常の役割の解明と治療薬の検討
2017 - 2020 Role of a functional SNP of the gene coding brain serotonin synthesis rate-limiting enzyme Tph2 in dilated cardiomyopathy
2017 - 2020 Role of a functional SNP of the gene coding brain serotonin synthesis rate-limiting enzyme Tph2 in dilated cardiomyopathyRole of a functional SNP of the gene coding brain serotonin synthesis rate-limiting enzyme Tph2 in dilated cardiomyopathy

2017 - 2020 拡張型心筋症における脳セロトニン合成律速酵素Tph2遺伝子機能的多型の役割

2016 - 2019 Evaluation of cardiac function for DCM and HCM knock-in model mouse during early postnatal development

2015 - 2019 Elucidation of cardiomyopathy caused by gene mutations induced environmental stresses -exhaustive mutation analysis and genome editing-genome

2016 - 2019 ノックインマウスを用いたヒト遺伝性心筋症の病態形成メカニズム解明と治療薬の検討

2015 - 2018 環境ストレスで生じた遺伝子変異による難治疾患の発症解明-網羅的解析とゲノム編集-

2013 - 2016 Role of GSK3b-mediated suppression of cardiac hypertrophy in heart failure

2012 - 2015 Exploration of anti-arrhythmic drugs acting on RyR2 using myocardium and cultured cells.

2013 - 2015 Role of GSK3b-mediated suppression of cardiac hypertrophy in heart failure

2011 - 2014 Pathogenic mechanism of congestive heart failure in a mouse model of dilated cardiomyopathy with brain serotonin dysfunction

2010 - 2013 脳内セロトニン低下を伴う拡張型心筋症モデルマウスの心不全発症メカニズムの解明

2010 - 2013 Molecular mechanisms of an improvement in prognosis in the mouse model of dilated cardiomyopathy treated by inhibition of the RAA system

2011 - 2012 Fundamental study on developing heart failure treatment targeting the central nervous system.

2007 - 2009 Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T

2006 - 2009 心不全の成因と治療に関する分子生理学的研究

2008 - 2009 心筋トロポニンT遺伝子突然変異による肥大型心筋症の病態発現機構の解明

2007 - 2009 Molecular mechanism of contractile dysfunction and the alteration of intracellular Ca^<2+> handling caused by mutation of cardiac troponin T

2007 - 2008 肥大型心筋症ノックインマウスの作製と解析

2005 - 2007 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

1999 - 2006 アクチンフィラメントの構造と動態の解析による筋収縮・調節機構の解明

2005 - 2006 トロポニン分子突然変異による遺伝性心筋症の病態発現機構の解明

2005 - 2006 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

2003 - 2005 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

2003 - 2004 Exploration of the pathogenic mechanisms of inherited cardiomyopathies caused by cardiac troponin T mutations

1999 - 2001 Functional analyset of mutations in human cardiac troponin T that cause familial hypertrophic cardiomyopathy

1999 - 2000 Functional analyset of mutations in human cardiac troponin T that cause familial hypertrophic cardiomyopathy

1998 - 1999 家族性肥大型心筋症を引き起こすヒト心筋トロポニンTミュータントの生理学的機能解析

1996 - 1999 Molecular mechanism of pH sensitivity of muscle contraction : investigation using site-directed mutagenesis

1995 - 1998 Molecular mechanisms of change in Ca^<2+>-sensitivity of muscle contraction induced by pH-reduction

1995 - 1998 心筋収縮のアシドーシス感受性に対するトロポニンサブユニットの役割

1996 - 1998 Molecular mechanism of pH sensitivity of muscle contraction : investigation using site-directed mutagenesis

1993 - 1997 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1995 - 1997 Molecular mechanisms of change in Ca^<2+>-sensitivity of muscle contraction induced by pH-reduction

1995 - 1995 心筋収縮のアシドーシス感受性に対するトロポニンサブユニットの役割

1993 - 1994 血管平滑筋の収縮弛緩調節機序

1992 - 1993 血管平滑筋の収縮制御機構

1993 - 1993 血管平滑筋の収縮弛緩調節機序

1993 - 1993 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1992 - 1992 血管平滑筋の収縮弛緩調節機序

1992 - 1992 血管平滑筋脱鞘筋線維のCa^<2+>非感受性異常収縮の発生機序及び脳血管れん縮との関連

1991 - 1991 血管平滑筋の収縮弛緩調節機序

1988 - 1989 筋収縮におけるCa2+受容タンパク質トロポニンCの作用発現機構

Investigation of pathogenic mechanisms of cardiomyopathy and development of therapeutic drugs using knock-in mouse mdels

Molecular mechanism of calcium-dependent regulation of muscle contraction

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Papers (134)：

Mai Takenaka, Masami Kodama, Takashi Murayama, Mari Ishigami-Yuasa, Shuichi Mori, Ryosuke Ishida, Junji Suzuki, Kazunori Kanemaru, Masami Sugihara, Masamitsu Iino, et al. Screening for Novel Type 2 Ryanodine Receptor Inhibitors by Endoplasmic Reticulum Ca²⁺Monitoring. Molecular Pharmacology. 2023. 104. 6. 275-286
Norio Fukuda, Henk Granzier, Shin’ichi Ishiwata, Sachio Morimoto. Editorial: Recent Advances on Myocardium Physiology, Volume II. Frontiers in Physiology. 2023. 14
Masataka Ikeda, Tomomi Ide, Shouji Matsushima, Soichiro Ikeda, Kosuke Okabe, Akihito Ishikita, Tomonori Tadokoro, Masashi Sada, Ko Abe, Midori Sato, et al. Immunomodulatory Cell Therapy Using αGalCer-Pulsed Dendritic Cells Ameliorates Heart Failure in a Murine Dilated Cardiomyopathy Model. Circulation. Heart failure. 2022. 15. 12. e009366
Hideaki Inazumi, Koichiro Kuwahara, Yasuaki Nakagawa, Yoshihiro Kuwabara, Takuro Numaga-Tomita, Toshihide Kashihara, Tsutomu Nakada, Nagomi Kurebayashi, Miku Oya, Miki Nonaka, et al. NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis. Circulation research. 2021. 130. 2. 234-248
Masahiro Yamamoto, Shinsuke Hanatani, Satoshi Araki, Yasuhiro Izumiya, Toshihiro Yamada, Nobuhiro Nakanishi, Toshifumi Ishida, Satoru Yamamura, Yuichi Kimura, Yuichiro Arima, et al. HE4 Predicts Progressive Fibrosis and Cardiovascular Events in Patients With Dilated Cardiomyopathy. Journal of the American Heart Association. 2021. 10. 15. e021069

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MISC (141)：

杉原匡美, 柿木亮, 村山尚, 平山哲, 三井田孝, 森本幸生, 呉林なごみ. 拡張型心筋症モデルにおける性差による自発運動の効果の違い. 臨床病理. 2020. 68
Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi. Sexual differences on effects of voluntary exercise on heart failure in DCM model mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2020. 93. 0. 2-P-207
Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi. Daily voluntary exercise suppresses progression of heart failure in DCM model mice. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 0. 1-P-057
杉原匡美, 柿木亮, 村山尚, 平山哲, 森本幸生, 呉林なごみ, 三井田孝. 拡張型心筋症モデルマウスにおける自発運動の頻度と心不全進行との関係. 臨床病理. 2018. 66. 補冊. 147-147
Sugihara Masami, Kakigi Ryo, Murayama Takashi, Miida Takashi, Sakurai Takashi, Morimoto Sachio, Kurebayashi Nagomi. Relation between Voluntary Exercise Frequency and Cardiac Function in Dilated Cardiomyopathy Model Mice. BIOPHYSICAL JOURNAL. 2018. 114. 3. 140A

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Patents (1)：

心不全治療に有益な新規カルシウムセンシタイザー

Books (4)：

心不全(第2版)上-最新の基礎・臨床研究の進歩-
日本臨牀社 76巻増刊号9(通巻1155号) 2018
肥大型心筋症ハンドブック - life long disease としてのマネジメント
日本医事新報社 2007 ISBN:9784784954162
モデル動物の作製と維持
(株)エル・エス・シー 2004
医科生化学
講談社 2000 ISBN:406153663X

Lectures and oral presentations (10)：

Myofilament Ca sensitivity and genetic cardiomyopathies
(Cardiovascular and Metabolic Week 2018 2018)
Knockin mouse models of inherited cardiomyopathies and potential therapeutics
(2016 Chinese Rare Disease Conference(Wohun, China) 2016)
Up-regulation of type 2 iodothyronine deiodinase in dilate cardiomyopathy
(Cardiovascular System Dynamics Society XIX International Conference (Fukuoka,Japan) "Genetic and molecular risk for heart failure" 2010)
トロポニンと遺伝性心筋症
(Heart Failure Forum 2009, 武田薬品工業主催(千里阪急ホテル) 2009)
心筋症研究が拓いたトランスレーショナルリサーチ
(第85回日本生理学会大会 <サテライト企画> 名取禮二記念筋肉シンポジウム「筋肉の構造と機能のシンポジウム」(東京)森本幸生 2008)

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Works (6)：

The following cardiomyopathy model mice that have been successfully produced in our previous studies are available from Kumamoto University CARD (http://cardb.cc.kumamoto-u.ac.jp/transgenic/localeAction.do).
Transgenic mouse specifically expressing human ΔE160 mutant cardiac troponin T in the heart;;C57BL/6N-TgN(cTnT delta Glu160) 15 Imeg ;C57BL/6N-TgN(cTnT delta Glu160) 17 Imeg ;C57BL/6N-TgN(cTnT delta Glu160) 7 Imeg
Sachio Morimoto
Transgenic mouse specifically expressing human wild-type cardiac troponin T in the heart; cTnT wild-10 C57BL/6N-Tg(cTnTwild)10Imeg; cTnT wild-14 C57BL/6N-Tg(cTnTwild)14Imeg
Sachio Morimoto
Knock-out mouse of cardiac troponin T on C57BL6/J background (B6;129-Tnnt2tm1Mmto); Dilated cardiomyopathy model
Sachio Morimoto
Knock-in mouse with a cardiac troponin T △K210 mutation on BALB/c background (C.129(B6)-Tnnt2tm2Mmto ) ; Dilated cardiomyopathy model(die of severe CHF)
Sachio Morimoto

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Education (1)：

1984 - 1987 Kyushu University

Professional career (2)：

PhD(DSc) (Kyushu University)
MSc. (Kyushu University)

Work history (14)：

2017 - 現在 International University of Health and Wefare Department of Health Sciences at Fukuoka Professor
2007 - Laboratory of Clinical Pharmacology, Department of Bioinformatics,Section of Basic Medicine, Kyushu University Graduate School of Medicine Associate Professor
2004 - Kyushu University Graduate Scool of Medine, Department of Basic Medicine, Laboratory of Clinical Phamacology, Associate Professor
1998 - Kyushu University Graduate Scool of Medical Sciences, Department of Clinical Phamacology, Associate Professor
1997 - Kyushu University School of Medicine

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Committee career (11)：

2018 - 現在 Heliyon Editorial Board
2017 - 現在 World Journal of Pharmacology Editorial Board
2011 - 現在 World Journal of Hypertension Editorial Board
2011 - 現在 Journal of Geriatric Cardiology Editorial Board
2011 - 現在 Journal of Geriatric Cardiology Editorial Board

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Association Membership(s) (6)：

International Society of Heart Research , Biophysical Society , THE PHYSIOLOGICAL SOCIETY OF JAPAN , 日本薬理学会 , Biophysical Society , American Heart Association

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