Sasaki Akira

2018 - 2021 The role of neuropeptide CGRP and regulatory mechanism for bone destruction in bone invasion and bone metastasis of oral cancer

2017 - 2020 Role and regulatory mechanisms of Semaphorin 4D in bone invasion of oral cancer.

2017 - 2020 The relationship between cancer-associted fibroblast and mast cell on the osteolysis of cancer induced bone disease

2017 - 2019 Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis

2016 - 2019 Function of PRL-3 in oral squamous cell carcinoma

2014 - 2017 Nicotine Induces Lymph Node Metastasis of Oral Cancer Cells through EGFR Activation

2014 - 2017 Role of cancer-associate fibroblasts on the regulation of angiognesis and bone resorption

2012 - 2015 Analysis of the biological role and the expression of angiogenin in the process of fracture healing

2011 - 2014 Development of molecular target therapy using new angiogenin inhibitor against cancer induced bone diseases

2008 - 2010 Angiogenin-induced differentiation of endothelial progenitor cell and the mechanism of tumor angiogenesis

2008 - 2010 Investigation of mechanism of angiogenesis factor, angiogenin, as a molecular target against cancer-induced bone destruction

2007 - 2008 癌誘発骨破壊病変の制御に立脚した血管骨代謝研究分野の創生に向けての基礎的研究

2006 - 2007 Investigation of the Mechanism of Angiogenin-Mediated Cancer Cell Proliferation and Tumor Angiogenesis, and Its Application for Cancer Treatment

2005 - 2007 The development of evaluation model of the cancer bone invasion reproducing bone microenvironment and the search of the new diagnosis marker for the cancer-induced bone resorption

2004 - 2005 ANALYSIS OF CISPLATIN RESISTANT TARGET FACTOR UNDER STRESS CONDITIOS IN SOLID TUMOR

2004 - 2005 THE EXPRESSION OF ANGIOGENIN IN ORAL CANCER AND ITS FUNCTIONS

2003 - 2004 Investigation of mechanism of methionine aminopeptidase-2 as a molecular target against cancer-induced bone destruction

2003 - 2004 Effect of topical administration of Bisphosphponate on bone resorption under denture base

2002 - 2003 ANALYSIS OF APOPTOSIS INDUCED MOLECULAR TARGET THERAPY OF CISPLATIN RESISTANT TUMOR UNDER STRESS CONDITIONS

2001 - 2002 Investigation of mechanism of connective tissue growth factor (CTGF) as a molecular target against cancer-induced bone destruction

2001 - 2002 INVESTIGATION OF HIF-1α TARGET MOLECULE THERAPY OF SOLID TUMORUNDER STRESS CONDITIONS

2000 - 2001 STUDY OF TUM0R SUPPRESSOR GENE AND ANGIOGENESIS IN ORAL CAJNCER -Effect of the transfection of p53 and p16 tumor suppressor genes on angiogenesis-.

2000 - 2001 EXPERIMENTAL STUDY OF MECHANISM OF ANGIOGENESIS INHIBITOR, TNP-470 ON THE BONE METABOLISM AND CLINICAL APPROACH FOR HUMORAL HYPERCALCEMIA OF MARIGNANCY.

1999 - 2001 EXPERIMENTAL STUDY OF GENE THERAPY FOR ORAL CANCER USING A TUMOR SUPPRESSOR GENE DOC-1.

1999 - 2000 INVESTIGATION OF MECHANISM OF MATRIX METALLOPROTEINASE ON THE ROLE OF BONE METABOLISM AND CLINICAL APPOACH FOR BONE INVASION AND OSTEOLYTIC LESIONS BY CANCER IN ANIMAL MODEL

1999 - 2000 The Experimental Research for Analysis and Treatment of Invasion of Ora Cancer. (Inhibitory effects regarding MMP production as target.)

1999 - 1999 口腔癌に特異的なTruncated EGF-Receptorの発現と治療への応用

1998 - 1999 INVESTIGATION OF MECHANISMS OF CDDP-INDUCED APOPTOSIS IN THE CDDP-RESISTANT A431 CELL LINE

1997 - 1999 INVESTIGATION OF MECHANISM OF BONE METTASTASIS AND MOLECULAR CLONING OF BONE METASITASIS RELATED GENE

1997 - 1998 INVESTIGATION OF MECHANISM OF ANGIOGENESIS INHIBITOR,TNP-470 ON THE ROLE OF BONE METABOLISM AND CLINICAL APPROACH FOR HUMAN ORAL CANTER JAW INVASION IN NUDE MICE MODEL.

1997 - 1998 EXAMINATION OF TELOMERASE ACTIVITY AND TUMOR SUPPRESSOR GENE ON HUMAN ORAL CANCERS

1996 - 1996 口腔癌の顎骨浸潤に対するビスフォスフォネートの応用に関する研究-放射線治療との併用効果ならびに骨への障害について-

1995 - 1995 口腔癌の顎骨浸潤の予防および治療におけるビスフォスフォネートの応用に関する研究