Rchr

J-GLOBAL ID：200901087098992479 Update date: Nov. 07, 2024

Miyata Atsuro

ミヤタアツロウ | Miyata Atsuro

Affiliation and department：
Job title： Professor

Research field (3)： Metabolism and endocrinology , Medical biochemistry , Pharmacology

Research keywords (7)：神経科学 , 内分泌学 , ペプチド生化学 , 分子薬理学 , Endocrimology , Molecular Pharmacology , Peptide Biochemistry

Research theme for competitive and other funds (35)：

2022 - 2026 PACAPによる神経細胞死防御の実体解明と神経再生・新生の基盤研究
2020 - 2023 腹内側核PACAP発現細胞の双方向性摂食調節メカニズムの解明と新規抗肥満薬の開発
2020 - 2023 Pathophysiological significance of neuron-astrocyte implication of PACAP on stress-induced emotional disorder
2016 - 2021 神経ペプチドPACAPによる脳・脊髄損傷の新規予防・治療法の開発と臨床応用研究
2017 - 2020 うつ病におけるミトコンドリア変性タンパク質ストレスレスポンスの関与の解明

2017 - 2020 アストロサイトPACAP/PAC1Rシグナルが関与する恐怖記憶メカニズムの解明

2016 - 2019 Verification of the importance of central FFAR1 system in nociceptive and emotional behaviors in mice

2015 - 2018 Investigation of pathogenic mechanisms for central post-stroke pain and its accompanying emotional disorder - evaluation of microglial activation hypothesis

2014 - 2017 Chronic pain treatment strategy targeting PACAP-PAC1-induced astrocyte signaling

2013 - 2016 Pathophysiologic significance of PACAP in hypothalamus

2013 - 2016 Research on the analgesic mechanism induced by the stimulation of the new free fatty acid receptor GPR40.

2011 - 2016 Basic and translational research for protection of neurodegeneration.

2012 - 2015 Development and pharmacological verification of a new mouse model of central post-stroke pain

2012 - 2015 Ghrelin and ghrelin autoabs in anorexia nervosa.

2011 - 2013 C-type natriuretic peptide modulates permeability of the blood-brain barrier

2009 - 2011 Testis-specific production and its physiological significance of PACAP

2006 - 2007 Testis specific regulatory mechanism of human PACAP gene expression

2006 - 2007 Neuroprotection factor of C-type natriuretic peptide (CNP)

2007 - PACAPの精巣特異的発現調節機序の解明

2003 - 2004 脊髄損傷におけるPACAPの脊髄細胞保護効果とその作用機序に関する研究

2002 - 2003 Neuroprotective effects of a pituitary adenylate cyclase activating polypeptide(PACAP)in global cerebral ischemia and in hypoxic neuronal cultures

1999 - 2000 Tissue-specific regulatory mechanism of PACAP gene expression as a vasoregulatory or neurotrophic factor

1997 - 1998 血中KPACAP特異的結合因子の生化学的研究

1997 - 神経・グリア・血管系細胞の機能連関における神経保護因子PACAPの機能解析

1997 - Studies on Neurotrophic Actions of PACAP

1995 - 1996 The study for elucidation of pathophysiolgical role of pituitary adenylate cyclase activating polypeptide (PACAO) in the cardiovascular system

1995 - 循環調節因子としてのPACAPの病態生理的意義の解明

1995 - Pathophysiology of PACAP as a vasoregulator

1992 - 1994 Molecular Biological Study on the Regulation of Metabolism of Fatty Acid and its Derivatives

1990 - 1991 Molecular Biological Study on the Regulation of the Lipid Metabolism

1986 - 1986 β型ヒト心房性Na利尿ペプチドの合成ならびにその生理的意義の解明

1985 - 1986 麻酔下における水・電解質代謝と心房性利尿ホルモン,ADH,アルドステロンとの関連

神経栄養因子としてのPACAPの神経特異的遺伝子発現機序に関する研究

development of therapeutic drug for brain attack, pain, or ischemic heart disease

Studies on neuro-specific regulatory mechanism of PACAP gene expression as a neurotrophic factor

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Papers (86)：

Thi Thu Nguyen, Kohei Hashiguchi, James A Waschek, Atsuro Miyata, Yuki Kambe. The pivotal role of PACAP/PAC1R signaling from the anterior insular cortex to the locus coeruleus on anxiety-related behaviors of mice. Neurochemistry international. 2024. 180. 105879-105879
Yuki Kambe, Masafumi Youkai, Kohei Hashiguchi, Yoshimune Sameshima, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara. Spinal Astrocyte-Neuron Lactate Shuttle Contributes to the Pituitary Adenylate Cyclase-Activating Polypeptide/PAC1 Receptor-Induced Nociceptive Behaviors in Mice. Biomolecules. 2022. 12. 12
Yuki Kambe, Thanh Trung Nguyen, Toshiharu Yasaka, Thu Thi Nguyen, Yoshimune Sameshima, Kohei Hashiguchi, Norihito Shintani, Hitoshi Hashimoto, Takashi Kurihara, Atsuro Miyata. The Pivotal Role of Neuropeptide Crosstalk from Ventromedial-PACAP to Dorsomedial-Galanin in the Appetite Regulation in the Mouse Hypothalamus. Molecular Neurobiology. 2022
Yusuke Shintani, Yui Yamano, Manato Kuta, Rei Takeshita, Kazuhiro Takuma, Takuya Okada, Naoki Toyooka, Ichiro Takasaki, Atsuro Miyata, Takashi Kurihara, et al. Small-molecule non-peptide antagonists of the PACAP receptor attenuate acute restraint stress-induced anxiety-like behaviors in mice. Biochemical and biophysical research communications. 2022. 631. 146-151
神戸悠輝, 栗原崇, 宮田篤郎. 視床下部腹内側核PACAPによる神経ペプチドネットワークを介した摂食行動の調節. 日本内分泌学会雑誌. 2022. 98. 1. 308-308

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MISC (79)：

MORIOKA Hirofumi, IWATA Shin-ichi, MIYATA Atsuro. Gene expression alteration in the mouse prefrontal cortex after chronic administration of antipsychotic drugs : Quantification of gene expression by adaptor-tagged competitive PCR. 2003. 23. 6. 263-263
T Nishikimi, Y Hayashi, G Iribu, S Takishita, Y Kosakai, N Minamino, A Miyata, H Matsuo, M Kuro, K Kangawa. Increased plasma adrenomedullin concentrations during cardiac surgery. CLINICAL SCIENCE. 1998. 94. 6. 585-590
H Takeshima, M Shimuta, S Komazaki, K Ohmi, M Nishi, M Iino, A Miyata, K Kangawa. Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle. BIOCHEMICAL JOURNAL. 1998. 331. 317-322
T Ishimitsu, A Miyata, H Matsuoka, K Kangawa. Transcriptional regulation of human adrenomedullin gene in vascular endothelial cells. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998. 243. 2. 463-470
Y Yoshitomi, T Nishikimi, S Kojima, M Kuramochi, S Takishita, H Matsuoka, A Miyata, H Matsuo, K Kangawa. Plasma levels of adrenomedullin in patients with acute myocardial infarction. CLINICAL SCIENCE. 1998. 94. 2. 135-139

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Books (11)：

Function of PACAP in the Cardiovascular System. Pituitary Adenylate Cyclase-Activating Polypeptide (H. Vaudry & A. Arimura ed.)
Kluwer Academic Publishers 2003
Structure and functions of pituitary adenylate cyclase activating polypeptide (PACAP) as a neurotrophic factor. Strategic Medical Science against Brain Attack(H. Kikuchi ed.)
Springer-Verlag Tokyo 2002
Molecular cloning of prostacyclin synthase from bovine endothelial cells(K. V. Honn et al., Ed.)
Eicosanoids and other bioactive lipids in cancer, inflamation, and radiation injury 2 1997
Structure and function of the serine pathway enzymes in Hyphomicrobium(M.E.Lidstrom and F.R.Tabita, Ed.)
Microbial Growth on C1 Compounds 1996
Thromboxane and Leukotriene Research : Human genes for prostaglandin endoperoxide synthase-2, thromboxane synthase and prostacyclin synthase(B. Sameulsson et al., Ed.)
Advances in Prostagrandin 1995

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Education (4)：

- 1985 Miyazaki Medical College
- 1985 Miyazaki Medical College Graduate School, Division of Medicine
- 1981 Miyazaki Medical College
- 1981 Miyazaki Medical College Faculty of Medicine

Professional career (1)：

M.D. & Ph.D. (*Miyazaki Medical College*)

Work history (15)：

2003 - 現在 Kagoshima University Graduate School of Medical and Dental Sciences
2000 - 2003 Kagoshima University Faculty of Medicine
2000 - 2003 Kagoshima University School of Medicine Professor
1994 - 2000 国立循環器病センター研究所室長
1994 - 2000 National Cardiovascular Center Research Institute Laboratory Head

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Committee career (4)：

2015/04 - 現在日本薬理学会理事
2000 - 日本心血管内分泌代謝学会評議員
2000 - 日本薬理学会評議員
The Japanese Pharmacological Society councilman

Awards (1)：

1998 - 日本神経内分泌学会川上賞

Association Membership(s) (9)：

THE JAPAN NEUROSCIENCE SOCIETY , 日本心血管内分泌代謝学会 , 北米神経科学会 , 日本薬理学会 , 日本内分泌学会 , 日本生化学会 , The Japanese Pharmacological Society , The Endocrine Society , Society for NeuroScience

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