Endo Hitoshi

エンドウヒトシ | Endo Hitoshi

Affiliation and department：
Job title： Professor

Research field (1)： Medical biochemistry

Research keywords (6)：遺伝子発現調節 , 生体エネルギー学 , 生化学 , Gene expression regulation , Energy transduction , Biochemistry

Research theme for competitive and other funds (26)：

2021 - 2024 疾患iPS細胞によるピルビン酸脱水素酵素欠損症の研究基盤の開発
2020 - 2023 Study of the new therapeutic target of fatty acid metabolism for malignant glioma
2020 - 2023 Lipid-derived acetyl-CoA promotes lipid-specific gene expression in alloreactive T-cells
2017 - 2020 Study for the mechanism of mitochondrial-nuclear compatibility and the development of therapeutic methods
2010 - 2012 Study for metabolic regulatory mechanism by a mitochondrial protein and a sex hormone

2006 - 2007 神経性RNA結合タンパク質に着目した吸入麻酔薬の中枢性麻酔薬作用の解析

2002 - 2004 A basic study for mitochondria-targeting liposome vector using human mitochondrial fusiogenic protein.

2002 - 2003 Involvement of the fibrin networks on the repairement of the injured blood vessels

2002 - 2002 筋分化システムに働くスプライシング因子の同定とその調節メカニズムの研究

2000 - 2002 無精子症の発現に関する新しい候補遺伝子の解明

1999 - 2001 STUDY FOR MOLECULAR MECHANISM OF MUSCLE-SPECIFIC ALTERNATIVE RNA SPLICING.

1996 - 1996 核孔を介したmRNA核外輸送に関与するRNA結合蛋白の解析

1995 - 1995 ATP合成酵素RNA前駆体における筋特異的スプライシング調節因子の研究

1995 - 1995 新たな方法によるヒトRNA結合蛋白のcDNAクローニングの研究

1994 - 1994 心筋分化におけるATP合成酵素の筋特異的選択的スプライシングの調節機構とその機能

1992 - 1994 Construction of transgenic mice into which mutant mitochondrial DNA is artificially introduced.

1993 - 1993 ミトコンドリア異常増殖腫瘍に関する分子遺伝子学的解析

1990 - 1993 Regulation factors in the human energy supplying system.

1992 - 1992 ピルビン酸脱水素酵素のTPP結合部位に関する分子生物学的研究

1991 - 1991 中鎖アシルCoA脱水素酵素欠損症の分子遺伝学的研究

1990 - 1991 Genetic analysis of pyruvate dehydrogenase deficiency and a study on pathogenesis of this disease

1990 - 1990 ピルビン酸脱水素酵素複合体欠損症の分子生物学的研究

ミトコンドリア膜タンパク質の網羅的プロテオーム解析

RNAプロセシングの分子メカニズムの研究

Study for molecular mechanism of RNA processing

Study for comprehensive proteomic analysis of mitochondrial membrane proteins

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Papers (82)：

Hirofumi Nakano, Kazuya Sato, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Takashi Ikeda, Shin-Ichiro Kawaguchi, Kiyomi Mashima, Kento Umino, Kaoru Morita, et al. Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease. ImmunoHorizons. 2024. 8. 3. 228-241
Kaoru Tominaga, Eiji Sakashita, Katsumi Kasashima, Kenji Kuroiwa, Yasumitsu Nagao, Naoki Iwamori, Hitoshi Endo. Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells. International Journal of Molecular Sciences. 2023. 24. 3. 2113-2113
Eiji Sakashita, Katsuya Nagatani, Hitoshi Endo, Seiji Minota. Serum level of IFNβ distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis. Scientific Reports. 2022. 12. 1
Kiyomi Mashima, Kazuya Sato, Takashi Ikeda, Junko Izawa, Norihito Takayama, Hiroko Hayakawa, Shin-Ichiro Kawaguchi, Hirofumi Nakano, Takashi Nagayama, Kento Umino, et al. Dimethyl fumarate ameliorates graft-versus-host disease by inhibiting T-cell metabolism and immune responses through a reactive oxygen species-dependent mechanism. British journal of haematology. 2022
Katsuya Nagatani, Eiji Sakashita, Hitoshi Endo, Seiji Minota. A novel multi-biomarker combination predicting relapse from long-term remission after discontinuation of biological drugs in rheumatoid arthritis. Scientific reports. 2021. 11. 1. 20771-20771

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MISC (19)：

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Patents (11)：

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Books (1)：

Heart/muscle-specific alternative splicing in ATP Synthase r-subunit pre-mRNA during muscle development
Cardiac Development and Gene Regulation (Ed. by Y. Yazaki) Excerpta Medica. Tokyo. Japan 1995

Professional career (1)：

Association Membership(s) (4)：

日本RNA学会 , The RNA Society , 日本分子生物学会 , 日本生化学会

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