Research field (3)：
Prosthodontics
, Regenerative dentistry and dental engineering
, Conservative dentistry and endodontics
Research keywords (5)：
biomaterials
, platelet concentrates
, 歯周組織の再生
, Bone metabolism
, Regeneration of periodontal tissue
Research theme for competitive and other funds (39)：
2022 - 2025 アスリートの選手生命を救うPRP治療の確立に向けた基盤的研究
2021 - 2024 血小板に含まれるポリリン酸がPRP組織再生治療において果たす役割の解明
2019 - 2022 Morphologically faithful reconstruct the of the jawbone with 3D printed absorbable trays and the cultured periosteal cell graft
2018 - 2021 Possible anti-inflammatory effects of transcription factors contained in platelet microparticles and periodontal regeneration
2017 - 2020 Applied research of a high cellular affinity RGD motif rich recombinant peptide as the bone regeneration material
2015 - 2018 Theranostic study for neck micro-metastasis
2015 - 2017 The search of the marker which becomes the index of the genetic-instability of the cell for the cell therapy
2014 - 2017 Qualitative analysis of the activated bone metabolism in bone regeneration with the cultured autogenous periosteal cell grafting by high quality 3D-CT image analysis
2012 - 2016 Control of the internal and surface structures of biodegradable porous membranes with the aid of surfactants and their application to bioprocess
2012 - 2016 Developments of scaffolds and processing technology to maximize the osteogenic potential of cultured periosteal sheets
2012 - 2015 Tissue-engineering of cartilage by the use of alveolar bone-derived periosteal sheets
2012 - 2015 Affibody probes for near-infrared fluorescence imaging of cancer cells in sentinel lymph nodes
2012 - 2015 Making a cultured periosteal sheet advanced function by the blend with the demarcation making periodontal ligament cell and spreading out to the new treatment
2011 - 2013 PRFによる創傷治癒促進効果の機序解明と効果的組織工学的応用法の開発
2011 - 2013 Dual-modality imaging with Tc-99m and fluorescent indocyanine green using surface-modified silica nanoparticles for the image of malignant tumors
2009 - 2011 Developments of scaffolds and processing technology to maximize the osteogenic potential of cultured periosteal sheets
2009 - 2011 A fundamental study regarding the cultured periosteum and its scaffold leading to a novel periodontal regenerative treatment
2008 - 2010 Clinical bone regeneration for indication of implantology by cultivated autologous periosteum.
2008 - 2010 Development of cryopreservation of cultured periosteum sheets for hard tissue regeneration
2007 - 2008 Three-dimensional high density culture of periodontal ligament cells on porous Hap blocks and their osteogenic induction
2005 - 2007 Tissue engineered periodontal regeneration using human autologous derived cells
2004 - 2006 Osteoblast-specific CGRP receptor -expression of osteoblastic differentiation-independent non-type I CGRP receptor-
2002 - 2004 Development of Tissue-Engineered Periodontal Regeneration Using Platelet-Rich Plasma and Periodontal Ligament Cells
2001 - 2003 Approach to PTHrP gene therapy for oral cancer
2000 - 2001 in situ hybridization study on PTHrP gene expression in oral carcinoma
2000 - 2001 Studies on CGRP receptor subtypes and their specific intracellular signaling pathways in the periodontal tissue
1998 - 2000 Study on the relationship between PTHrP gene expression and differentiation of oral squamous cell carcinoma
1989 - 1990 Identification and Functional Analysis of Cytokine Receptors on Osteoblast and Osteoclast by Monoclonal Antibodies
1987 - 1988 Studies on Ca^<2+> mobilization in osteoblasts and in odontblasts in primary culture.
歯周組織の再生
Regeneration of periodontal tissue.
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Papers (135)：
Takashi Ushiki, tomoharu mochizuki, Mami, Katsuya Suzuki, Tetsuhiro Tsujino, Taisuke Watanabe, Carlos Fernando Mourão, Tomoyuki Kawase. Plasma Gel Matrix as a Promising Carrier of Epigallocatechin Gallate for Regenerative Medicine. Journal of Functional Biomaterials. 2024
Tomoharu Mochizuki, Takashi Ushiki, Katsuya Suzuki, Misato Sato, Hajime Ishiguro, Tatsuya Suwabe, Satoshi Watanabe, Mutsuaki Edama, Go Omori, Noriaki Yamamoto, et al. Elevated IL-1β and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players. International journal of molecular sciences. 2023. 24. 24
Takashi Uematsu, Hideo Masuki, Masayuki Nakamura, Hideo Kawabata, Yutaka Kitamura, Taisuke Watanabe, Takao Watanabe, Tomoharu Mochizuki, Takashi Ushiki, Tomoyuki Kawase. Metformin-suppressed platelet's function in vitro: Possible relation to delayed or failure of platelet-rich fibrin preparation. Toxicology in vitro : an international journal published in association with BIBRA. 2023. 93. 105692-105692
Tomoharu Mochizuki, Takashi Ushiki, Katsuya Suzuki, Misato Sato, Hajime Ishiguro, Tatsuya Suwabe, Mutsuaki Edama, Go Omori, Noriaki Yamamoto, Tomoyuki Kawase. Characterization of Leukocyte- and Platelet-Rich Plasma Derived from Female Collage Athletes: A Cross-Sectional Cohort Study Focusing on Growth Factor, Inflammatory Cytokines, and Anti-Inflammatory Cytokine Levels. International journal of molecular sciences. 2023. 24. 17
Tomoyuki Kawase, Katsuya Suzuki, Masami Kamimura, Tomoharu Mochizuki, Takashi Ushiki. Optimized Protocol for Preservation of Human Platelet Samples for Fluorometric Polyphosphate Quantification. Methods and protocols. 2023. 6. 4
1993 - 2002 Niigata University Faculty of Dentistry
1993 - 2002 Associate Professor, School of Dentistry,
2002 - -date 新潟大学大学院 准教授
2002 - -date Associate Professor, Graduate School of Medical
1992 - 1993 Niigata University Faculty of Dentistry
1992 - 1993 Assistant Professor, School of Dentistry,
1986 - 1992 Niigata University Faculty of Dentistry
1986 - 1992 Research Associate, School of Dentistry,
and Dental Sciences, Niigata Univ.
Niigata Univ.
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Committee career (4)：
1998 - 現在 歯科基礎医学会 評議員
1994 - 現在 日本薬理学会 学術評議員
- 現在 日本歯周病学会 評議員
- 現在 日本再生医療学会 代議員
Awards (1)：
1993 - 歯科基礎医学会賞
Association Membership(s) (8)：
Academy of Osseointegration
, Tissue Engineering and Regenerative Medicine
, JAPANESE SOCIETY OF ORAL IMPLANTOLOGY
, THE JAPANESE SOCIETY FOR BIOMATERIALS
, THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
, 日本歯周病学会
, 歯科基礎医学会
, 日本薬理学会
