Rchr
J-GLOBAL ID:200901088261870153
Update date: Sep. 07, 2024
Sasayama Takashi
ササヤマ タカシ | Sasayama Takashi
Affiliation and department:
Job title:
Associate Professor
Research field (3):
Tumor diagnostics and therapeutics
, Tumor biology
, Neurosurgery
Research theme for competitive and other funds (32):
- 2024 - 2027 A Prognosis Prediction-based Stratification Method to Build an Evidence Base for the Treatment of Traumatic Brain Injury
- 2023 - 2027 Minimally invasive brain network mapping for preserving brain functions and predicting plasticity
- 2023 - 2026 Development of the physiologic marker of E/I balance of the human brain
- 2022 - 2025 Development of new treatments for medulloblastoma targeting macrophage
- 2022 - 2025 Developments of surgical systems for skull base surgery and surgical education
- 2022 - 2025 カルベノキソロンの作用を通して行う脳虚血の包括的メカニズムの解明と治療法の探究
- 2022 - 2025 Investigation for the molecular biological role of myoglobin in the cerebral aneurysm walls
- 2022 - 2025 Language brain representation and its reorganization after brain surgery: an ECoG connectome study.
- 2021 - 2024 Development of therapeutic agents for glioblastoma based on the synthesis of bronanserin metabolites and new derivatives
- 2020 - 2023 膠芽腫に対するアミノ酸代謝阻害併用ケトン食療法の基礎的研究
- 2020 - 2023 One carbon metabolism for glioma cells to survive glutamine starvation
- 2018 - 2021 脳虚血再灌流障害におけるATMキナーゼ経路の役割解明と新たな脳梗塞治療への応用
- 2018 - 2021 腫瘍関連マクロファージ免疫チェックポイント阻害による新規膠芽腫治療法の基礎研究
- 2018 - 2021 メタボローム解析を用いた原発性中枢性リンパ腫における新規バイオマーカーの探索
- 2017 - 2020 Analysis of neurofunctional network in resting state by intraoperative 3T fMRI
- 2017 - 2020 Analysis of dissemination factor of glioma cells
- 2017 - 2020 Target therapy of glutamine metabolism in glioma with IDH mutation
- 2015 - 2018 Development of precise brain model reflecting displacement / deformability based on MRI analysis
- 2015 - 2018 A study of new treatment by JAK-STAT inhibition for central nervous system lymphoma
- 2015 - 2018 Comprehennsive analysis of cerebral metabolic changes during ischemia-reperfusion by omics
- 2014 - 2017 Effect of microRNA -21 in cerebral ischemia.
- 2014 - 2017 Integrated analyses of GBM cell lines, in vivo xenograft models, and clinical samples to examine the glutamine metabolism in response to mTOR-targeted treatments
- 2013 - 2016 Diagnostic value of tumor metabolites in metabolome analysis for glioma patients
- 2013 - 2016 microRNA aberration in gliomas with IDH mutation and metastasis
- 2010 - 2012 Selective brain tumor cell death caused by synchrotron microbeam X-ray radiation
- 2010 - 2012 MicroRNA associated with prognostic factor in glioma
- 2007 - 2008 シンクロトロンによるマイクロビームを用いた悪性脳腫瘍の新しい治療法の確立
- 2005 - 2007 オーロラAのsiRNA導入によるグリオーマ移植細胞に対する抗腫瘍効果の解析
- 2004 - 2006 Genetic analysis of drug resistant malignant glioma cells by CHG and microarray
- 2003 - 2005 Basic research for the combination with anti-angiogenic therapy and heavy charged particle therapy against malignant gliomas
- 2005 - CGH、マイクロアレイの臨床応用による薬剤耐性悪性神経膠腫の遺伝子診断の確立
- 2005 - 重粒子線と血管新生阻止療法を併用した悪性神経膠腫の局所制御に関する基礎的研究
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Papers (168):
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Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama. Potential of GSPT1 as a novel target for glioblastoma therapy. Cell Death & Disease. 2024. 15. 8
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池内 佑介, 田中 一寛, 細田 弘吉, 山西 俊介, 長嶋 宏明, 伊藤 智雄, 立石 健祐, 笹目 丈, 篠山 隆司. 悪性リンパ腫の診断・治療の現状と展望 Interleukin 10を元に分類した中枢神経原発悪性リンパ腫の網羅的解析. Brain Tumor Pathology. 2024. 41. Suppl. 104-104
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池内 佑介, 田中 一寛, 細田 弘吉, 山西 俊介, 長嶋 宏明, 伊藤 智雄, 立石 健祐, 笹目 丈, 篠山 隆司. 悪性リンパ腫の診断・治療の現状と展望 Interleukin 10を元に分類した中枢神経原発悪性リンパ腫の網羅的解析. Brain Tumor Pathology. 2024. 41. Suppl. 104-104
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Yusuke Ikeuchi, Atsushi Fujita, Masaaki Kohta, Shunsuke Yamanishi, Kazuhiro Tanaka, Takashi Sasayama. Multiple Synchronous Spinal Dural Arteriovenous Fistulas: A Systematic Literature Review. Neurosurgery. 2024
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Tatsuya Mori, Hidehito Kimura, Atsushi Fujita, Kosuke Hayashi, Tatsuo Hori, Masahiro Sugihara, Yusuke Ikeuchi, Masaaki Kohta, Akio Tomiyama, Takashi Sasayama. A vertebrobasilar junction aneurysm successfully treated with a combination of surgical clipping and flow diverter placement based on the results of computational fluid dynamics analysis: illustrative case. Journal of Neurosurgery: Case Lessons. 2024. 7. 10
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MISC (134):
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中田光俊, 大槻純男, 内田康雄, 中嶋理帆, 篠山隆司, 長嶋宏明, 立石健祐, 齋藤紀彦, 平井希, 棗田学, et al. Multiinstitutional research to identify the blood biomarkers for diagnosing the state of glioblastoma after standard treatment. 日本脳腫瘍学会学術集会プログラム・抄録集. 2022. 40th
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Hiroaki Nagashima, Kazuhiro Tanaka, Yuichi Fujita, Mitsuru Hashiguchi, Mashahiro Maeyama, Yuichiro Somiya, Takanori Hirose, Tomoo Itoh, Takashi Sasayama. 2-HYDROXYGLUTARATE MAGNETIC RESONANCE SPECTROSCOPY IN ADULT BRAINSTEM GLIOMA PATIENTS. NEURO-ONCOLOGY. 2021. 23. 131-131
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Kazuhiro Tanaka, Hiroaki Nagashima, Yuichi Fujita, Mitsuru Hashiguchi, Takashi Sasayama. GLIOMA CELLS REPROGRAM SERINE-DEPENDENT ONE-CARBON METABOLISM TO SURVIVE GLUTAMINE STARVATION. NEURO-ONCOLOGY. 2021. 23. 202-202
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長嶋宏明, 長嶋宏明, LEE Christine, 立石建祐, 樋口芙未, 田中一寛, 篠山隆司, MILLERT Julie, 脇本浩明, CAHILL Daniel. ポリ(ADP-リボース)グリコヒドロラーゼ阻害はNAD+を隔離し,IDH変異腫瘍細胞におけるアルキル化化学療法の代謝致死性を増強する. 日本分子脳神経外科学会プログラム・抄録集. 2021. 21st
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長嶋宏明, 長嶋宏明, 田中一寛, 篠山隆司. PARG阻害はNAD+を隔離し,IDH変異腫瘍細胞におけるアルキル化化学療法の代謝致死性を増強する. 日本癌学会学術総会抄録集(Web). 2021. 80th
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Books (2):
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神経症候群(第2版)III -その他の神経疾患を含めて- / 髄膜肉腫症
日本臨床 2014
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Neurosurgery Now 5 グリオーマ その最新知見 / 腫瘍発生の遺伝子解析
メジカルビュー 2009
Lectures and oral presentations (237):
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中枢神経悪性リンパ腫の診断バイオマーカーとしてのCXCL13の検討
(第36回日本脳腫瘍学会 2018)
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グルタミン飢餓状態のグリオーマ細胞における一炭素代謝の調整と新規治療標的の探索
(第36回日本脳腫瘍学会 2018)
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悪性脳腫瘍に対する光線力学療法 (PDT)の治療経験
(日本脳神経外科光線力学学会 2018)
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Interleukin-6 in Cerebrospinal Fluid as a Prognostic Marker for Glioblastoma Patients
(23rd Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO) 2018)
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Glutamine deprivation alters one-carbon metabolism to maintain glioma cell survival
(23rd Annual Scientific Meeting and Education Day of the society for Neuro-Oncology (SNO) 2018)
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Education (2):
- 1999 - 2003 Kobe University Graduate School of Medicine
- 1988 - 1994 Kobe University School of Medicine Faculty of Medicine
Professional career (2):
- 医学学士 (神戸大学)
- 博士(医学) (神戸大学)
Work history (5):
- 2020/09 - 現在 神戸大学大学院医学研究科 外科系講座 脳神経外科学分野 教授
- 2010/04 - 2020/08 Kobe University University Hospital
- 2007/04 - 2010/03 Kobe University University Hospital
- 2005/11 - 2007/03 Kobe University University Hospital
- 2003/10 - 2005/10 Kobe University University Hospital
Committee career (3):
- 2019/09 - 現在 日本脳神経外科学会 代議員
- 2018/05 - 現在 日本脳神経外科コングレス 運営委員
- 2015/08 - 現在 日本分子脳神経外科学会 学術企画運営委員
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