Miyatake Shin'ichi

2016 - 2021 The novel bladder preservation therapy by selective destruction of cancercells "Boron Neutron Capture Therapy at bladder"

2017 - 2020 Clinical trial of boron neutron capture therapy with the combination of successive bevacizumab treatments for recurrent malignant gliomas

2017 - 2019 Usefulness of a super selective arterial infusion therapy of a novel boronated porphyrin for BNCT and PDT

2015 - 2018 Development of new boron drugs and molecular imaging targeting for cancer stem cell

2015 - 2018 Impact of M2 macrophages on glioma-relevant radiation necrosis of the brain

2014 - 2017 Analysis of pathophysiology of brain radiation necrosis and establishment of novel treatment strategy

2014 - 2017 An attempt to improve the possibilities of controlling local tumors through taking it into account to increase the sensitivity of oxic quiescent tumor cells

2012 - 2015 tumor specific new boron agent for BNCT

2012 - 2014 Not only angiogenesis but also inflammation participate in the pathophysiology of brain radiation necrosis

2012 - 2014 Novel bladder preservation therapy: BNCT-BOAI-Radiation, which selectively target cancer cells with very few complications

2011 - 2014 Tumor-selective high LET and high RBE particles can overcome the radiation-resistant glioma stem cells

2011 - 2011 Patho-physiology of the radiation necrosis in the brain

2010 - 2011 Novel cancer targeted organ preservation therapy, balloon occluded arterial infusion combined with boron neutron capture therapy, for invasive bladder cancer

2005 - 2009 Basic study on cancer cell selective radiotherapy by particle beam

2007 - 2008 Development of boron neutron capture therapy for the standard treatment of malignant brain tumors

2006 - 2007 Experimental and Clinical Study on Boron Neutron Capture Therapy for Oral cancer

2006 - 2007 短半減期エリスロポイエチン誘導体とFGF2を用いた神経再生と神経保護の研究

2005 - 2006 Regeneration of neurons and vessels using bone marrow cells and gene delivery

2005 - 2006 Development of fluorescence guided navigation system using a near infra-red fluorescent agent

2004 - 2005 Boron neutron capture therapy on malignant brain tumors.

2004 - 2005 悪性脳腫瘍におけるサバイビンmRNA発現量の定量的解析と遺伝子治療への応用

2003 - 2005 An approach for ALS genetic therapy using Herpes Simplex Virus Vector

2003 - 2004 DEVELOPMENT OF SENSOR TYPE TUMOR RESECTION ROBOT SYSTEM

2002 - 2003 Angiogenesis with bone marrow cells and gene therapy

2002 - 2003 Intra-operative identification of malignant glioma using real-time fluorescence spectroscopic analysis and double staining method

2002 - 2003 動脈硬化および臓器移植後血管狭窄に対する特異的複製可能型ウイルスによる遺伝子治療

2001 - 2002 a novel therapy for metastatic liver cancer using cancer specific replicating HSV-1

2001 - 2002 Effect of herpes simplex virus vector, d12CALP, on vasospasm in rabbit common carotid artery with atherosclerotic changes

2000 - 2001 Pharmacological study on the role of amygdala in sensory and affective components of pain

2000 - 2001 Gene therapy for vascular stenosis using replieation-competent HSV vector

1999 - 2000 Roles of fractalkine in neuron-microglia interaction at brain injury

1998 - 2000 Development of predictive assays for radiosensitivity, chemosensitivit apoptosis, and proliferative activity of tumor and normal tissues

1998 - 1999 Gene Therapy for analignant using fumor-Specific HSV

1996 - 1998 Gene therapy for brain fumor using adenovirus-vector with integrinalpha_3

1997 - 1997 サイトカイン遺伝子及び単純ヘルペスウイルスを用いた悪性脳腫瘍への遺伝子治療の研究

1996 - 1997 Adenovirus-mediated gene therapy for cerebrovascular disorders

1995 - 1996 Transoriptional Tayiting of herpes simplex virus for cell-specific replication

1995 - 1995 深在性放射線抵抗性腫瘍に対する熱・熱外中性子捕捉治療の開発

1991 - 1992 Trial for new cancer therapy by transfection of cytokine genes

1991 - 1991 微小核試験による初代培養腫瘍細胞の放射線感受性測定と最適放射線療法の研究

1990 - 1990 遺伝子操作により抗腫瘍活性を増強したエフェクタ-細胞の樹立と新しい免疫療法の開発

1989 - 1989 脳腫瘍関連抗原に対するモノクローナル抗体の作製及びその臨床治療への応用

神経腫瘍学

硼素中世子捕捉療法

神経変性疾患に対する遺伝子治療

脳血管障害の遺伝子治療

脳腫瘍の遺伝子治療

Neuro-Oncology

Boron neutron capture therapy

Gene therapy for neuro-degenerative disease

Gene therapy for cerebralvascular disease

Gene therapy for hain tumor