Rchr
J-GLOBAL ID:200901088895652396
Update date: May. 04, 2024
Utsumi Hideo
ウツミ ヒデオ | Utsumi Hideo
Affiliation and department:
Job title:
Visiting Professor
Research field (1):
Pharmaceuticals - analytical and physicochemistry
Research keywords (2):
フリーラジカル
, 磁気共鳴
Research theme for competitive and other funds (53):
- 2016 - 2019 Studies on the Development of Clinical Free Radical Imaging Systme
- 2013 - 2016 Development of free radical imaging using in vivo DNP-MRI
- 2010 - 2012 Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRI
- 2010 - 2012 Non-invasive assessment for therapeutic response to gene therapy using redox imaging and MALDI-TOF mass-spectrometry
- 2007 - 2010 Hypertension in metabolic syndrome : Mechanism involved in activation of the sympathetic nervous system and therapeutic approach
- 2004 - 2008 レドックス動態の磁気共鳴統合画像解析システム
- 2007 - 2007 酸化ストレス疾患における抗酸化物質の生体内効能の測定・評価
- 2006 - 2007 生体内レドックス分子イメージングのための新規ニトロキシルラジカル開発・評価
- 2003 - 2007 Application of Molecular Spins : from Nanomagnets to Biological Spin Systems
- 2004 - 2006 生体内フリーラジカル画像解析を目的とした新規画像再構成アルゴリズムの開発
- 2004 - 2006 Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)
- 2003 - 2006 Analysis of free radical reactions in diseases model animals using in vivo ESRI
- 2002 - 2004 Non-invasive analysis of dynamic state of reactive oxygen species in tissue and blood vessel of circulatory diseases
- 2002 - 2004 Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure
- 2002 - 2003 生体ラジカル二重共鳴画像解析用共振デバイスと画像化システムの開発
- 2001 - 2003 Development of ESRI・MRI fused imaging device for oxidative stress-related diseases
- 2001 - 2002 Elucidating the mechanism of heart failure using mouse model of dilated cardiomyopathy
- 2000 - 2001 Non-invasive evaluation of free radical reactions accompanied with induction and development of heart failure by in vivo ESR-CT
- 2000 - 2001 Mechanisms of oxygen radical generation in the mitochondria from the failing hearts
- 2000 - 2001 疾患成因に関わる活性酸素・活性窒素の無侵襲画像解析手法の開発
- 1999 - 2001 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-_B AND MCP-1
- 1998 - 2001 Development of non-invasive evaluation of oxidative stress against living organisms by in vivo ESR
- 1999 - 2000 Development of non-invasive system for the evaluation of free radicals in brain with encephalopathy.
- 1998 - 2000 MOLECULAR MECHANISMS OF CARDIOVASCULAR REMODELING INDUCED BY CHRONIC INHIBITION OF NITRIC OXIDE SYNTHESIS : ROLE OF NF-κB AND MCP-1
- 1998 - 1999 Analysis of toxicity by organic halogens with in vivo ESR and transgenic mice
- 1998 - 1999 生体計測ESRによる炎症時におけるレドックス代謝活性の無侵襲画像解析
- 1998 - 1998 水処理操作における有害物質の消長の検討
- 1998 - 1998 超微量分子および分子集合体の高度機能解析およびイメージングに関する研究
- 1998 - 1998 生体を指向した新しい電子スピン共鳴法の医学・薬学的応用
- 1996 - 1998 Development of Chronic Heart Failure Model Caused by Inflammatory Cytokines and Establishment of Prophylactic and Therapeutic Strategies for the Heart Failure
- 1997 - 1997 オゾン処理による水中有機物の反応経路の検討
- 1995 - 1997 ESR studies on biological free radicals in pharmaceutical sciences
- 1995 - 1997 Roles of in vivo REDOX systems by using in vivo ESR and transgenic mice
- 1993 - 1997 "Man-Earth System : A scientific approach to realize human society in harmony with the Earth"-Genetic Determinants Affecting Sensitivity to Environmental Factors-
- 1996 - 1996 脳細胞の生存・機能維持におけるフリーラジカルの関与
- 1996 - 1996 生体内で発生する活性酸素の無侵襲検出法の開発
- 1995 - 1996 EVALUATION OF THE MUTAGENICITY IN THE ENVIRONMENTAL WATER
- 1994 - 1996 Development of in vivo ESR for detecting free radicals in human living body
- 1995 - 1995 酸化ストレスに着目した有害物質の毒性評価法の開発
- 1994 - 1995 The study on comprehensive methods for estimaiton of new water treatment technology
- 1994 - 1994 培養細胞系を用いた有害物質の包括的評価法の開発
- 1993 - 1993 非特定多様有害物質の毒性低減化に向けた新評価法の開発
- 1991 - 1993 Development of a Method for Measuring Oxyngen Concentration in Biological Systems by Means of ESR
- 1991 - 1993 Study of Free Radicals in Tissue and Transdermal Drug Delivery by using in vivo ESR with Spectral-Spatial ESR-CT Imaging
- 1990 - 1992 Real Time Analysis of Drug-Diffusion in Muscle with in vivo ESR-Spectroscopy
- 1991 - 1991 Management and restoration of river ecosystem and resources
- 1990 - 1990 Analysis of Human Impacts on the Deterioration of an Aquatic Ecosystem in Korea and Development of a Computer-Aided System for Basin-Wide Management
- 1990 - 1990 生物関連汚濁に対応する水質改善技術
- 1987 - 1989 Development of in situ liver function measurement with a L-band ESR imaging technique
- 1985 - 1986 Studies on the relation between the biological function and the dynamic properties of rat liver plasma and microsomal membranes
- 1983 - 1984 細胞認識における膜タンパク質・脂質相互作用の意義に関する研究
- 1982 - 1982 外部シグナルと膜蛋白質・脂質相互作用
- 1981 - 1981 抗原・抗体反応における膜受容体蛋白質と膜脂質との相互作用に関する研究
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Papers (248):
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Keiji Yasukawa, Kazunori Yamada, Hiroto Tokuda, Susumu Koyama, Hideo Utsumi. Redox imaging of dextran sodium sulfate-induced colitis mice treated with nitric oxide synthase inhibitors. Advances in Redox Research. 2022. 6. 100047-100047
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Hideo Utsumi, Toshiki Masumizu, Ryoma Kobayashi, Tomoko Tahira, Fuminori Hyodo, Tatsuya Shimizu, Tatsuya Naganuma, Kazunori Anzai. Development and Preclinical Study of Free Radical Imaging Using Field-Cycling Dynamic Nuclear Polarization MRI. Analytical Chemistry. 2021. 93. 42. 14138-14145
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Fuminori Hyodo, Hinako Eto, Tatsuya Naganuma, Norikazu Koyasu, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masaharu Murata, Tomohiko Akahoshi, Makoto Hashizume, et al. In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. Antioxidants & redox signaling. 2021. 36. 1-3. 172-184
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Fuminori Hyodo, Shinji Ito, Hinako Eto, Abdelazim Elsayed Elhelaly, Masaharu Murata, Tomohiko Akahoshi, Hideo Utsumi, Masayuki Matuso. Free radical imaging of endogenous redox molecules using dynamic nuclear polarization magnetic resonance imaging. Free radical research. 2021. 55. 4. 343-351
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Keiji Yasukawa, Yukio Ishihara, Fumi Hirayama, Megumi Nakanishi, Hideo Utsumi, Susumu Koyama. Electricity use is associated with residents' vital data and lifestyles: observational study using an IT health support system in Japan. Scientific reports. 2020. 10. 1. 17162-17162
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MISC (23):
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兵藤文紀, 伊藤慎治, 江藤比奈子, 中路睦子, 内海英雄. 磁気共鳴イメージングによる新たなレドックス代謝イメージング法の開発. 日本分析化学会年会講演要旨集. 2015. 64年会. 2-2
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兵藤文紀, 伊藤慎治, 江藤比奈子, 中路睦子, 安川圭司, 小林竜馬, 内海英雄. 生体内分子・医薬品を用いた新たな代謝イメージング法の開発. 日本薬学会年会要旨集(CD-ROM). 2015. 135年会. 1. 147-147
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Keiji Yasukawa, Yoko Yamada, Kazuhiro Ichikawa, Hideo Utsumi. Visualization of Redox Imbalance in Mice with Indomethacin-induced Intestinal Damage and the Recovery Effect of Rebamipide Using Overhauser-Enhanced MRI. FREE RADICAL BIOLOGY AND MEDICINE. 2010. 49. S203-S203
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Shuichiro Araki, Yoshitaka Hirooka, Satomi Konno, Koji Ito, Takuya Kishi, Keiji Yasukawa, Hideo Utsumi, Kenji Sunagawa. Aldosterone and Salt Induce Hypertension in Association with Increased Oxidative Stress and Altered Glucose Metabolism in Apolipoprotein E-Deficient Mouse Brain. HYPERTENSION. 2009. 54. 4. E101-E101
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Shuichiro Araki, Yoshitaka Hirooka, Takuya Kishi, Koji Ito, Yasuaki Koga, Satomi Konno, Keiji Yasukawa, Hideo Utsumi, Kenji Sunagawa. Aldosterone and Salt Induces Hypertension Associated with Increased Oxidative Stress in the Brain of Apolipoprotein E Knockout Mice. FASEB JOURNAL. 2009. 23
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Education (2):
- - 1976 The University of Tokyo
- - 1971 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1):
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