Rchr
J-GLOBAL ID：200901088899721341   Update date: Aug. 27, 2024

Takahara Kazuhiko

タカハラ カズヒコ | Takahara Kazuhiko
Affiliation and department：
Kyoto University Graduate School of Biostudies, Division of Systemic Life Science, Graduate School of Biostudies DIVISION OF SYSTEMIC LIFE SCIENCE

About Kyoto University Graduate School of Biostudies, Division of Systemic Life Science, Graduate School of Biostudies DIVISION OF SYSTEMIC LIFE SCIENCE


Job title： Lecturer
Homepage URL  (1)： http://zoo.zool.kyoto-u.ac.jp/imm/
Research field  (2)： Immunology ,  Experimental pathology
Research keywords  (8)： Polysaccharides ,  Immune regulation ,  樹状細胞 ,  レクチン ,  免疫学 ,  Dendritic Cells ,  Lectin ,  Immunology
Research theme for competitive and other funds  (33)：
  • 2021 - 2024 病原体の免疫抑制機構を利用した致死的サイトカインストームを抑制する糖鎖の開発
  • 2020 - 2023 自然免疫系レセプターの胎生期リンパ球発生における新たな働き
  • 2016 - 2019 Immune control by polysaccharides derived from microbes
  • 2013 - 2016 Immune regulation though C-type lectin using microbial polysaccharides
  • 2013 - 2015 IL-1beta production depending on size of insoluble material generated in vivo
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Papers (55)：
  • Tanaka, S.†, Kawakita, M.†, Yasui, H., Sudo, K., Itoh, F., Sasaki, M., Shibata, N., Hara, H., Iwakura, Y., Hashidate-Yoshida, T., Shindou, H., Shimizu, T., Oyama, T., Matsunaga, H. and Takahara, K. († equall contribution). An immune-adrenergic pathway induces lethal levels of platelet-activating factor in mice. Communications Biology. 2024. 7
  • Koichi Sudo, Takero Todoroki, Yuyo Ka, Kazuhiko Takahara. Vγ5Vδ1 TCR signaling is required to different extents for embryonic versus postnatal development of DETCs. International Immunology. 2022
  • Kawakita, M., Oyama, T., Shirai, I., Tanaka, S., Akaki, K., Abe, S., Asahi, T., Cui, G., Itoh, F., Sasaki, M., Shibata, N., Ikuta, K., Hatakeyama, T. and Takahara, K. Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis. Commun. Biol. 2021. 4. 1. 342-342
  • Guangwei Cui, Akihiro Shimba, Guangyong Ma, Kazuhiko Takahara, Shizue Tani-Ichi, Yuanbo Zhu, Takuma Asahi, Akifumi Abe, Hitoshi Miyachi, Satsuki Kitano, et al. IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis. Journal of immunology (Baltimore, Md. : 1950). 2020. 204. 4. 844-857
  • Takeo Goji, Kazuhiko Takahara, Manabu Negishi, Hironori Katoh. Cystine uptake through the cystine/glutamate antiporter xCT triggers glioblastoma cell death under glucose deprivation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 48. 19721-19732
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MISC (11)：
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Patents (7)：
  • インスリン結合阻害剤
  • インスリン結合用担体
  • Mammalian Tolloid-Like Gene and Protein
  • 逆転写酵素遺伝子
  • ヒトコラーゲンV型遺伝子
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Books (17)：
  • 京大発 フロンティア生命科学
    講談社 2018
  • Immune regulation though C-type lectin: Their roles in homeostasis and application
    Clinical Immunology & Allergology 2016
  • 微細粒子物質による炎症惹起
    臨床免疫・アレルギー科 2013
  • C-型レクチンDC-SIGNを介したIL-10産生と免疫制御.
    臨床免疫・アレルギー科 2013
  • 樹状細胞に発現するCタイプレクチンDCIR(Dendritic cell immunoreceptor)の機能と生体における働き)
    臨床免疫アレルギー科 2009
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Lectures and oral presentations  (3)：
  • 微細な粒子/蛋白凝集体はそのサイズ・形状により異なる細胞内応答経路を活性化する
    (広島醗酵会総会・公開講演会 2013)
  • 粒子サイズによる細胞応答性の差異
    (京都環境ナノクラスター主催「ナノ材料の安全性・社会受容に関するシンポジウム」 2012)
  • Role of SIGN-related molecules in innate immune responses
    (CREST Symposium 2009)
Education (4)：
  • - 1986 Hiroshima University
  • - 1986 Hiroshima University Graduate School, Division of Engineering
  • - 1984 Hiroshima University Faculty of Engineering
  • - 1984 Hiroshima University Faculty of Engineering
Professional career (1)：
  • Doctor of Engineering (Hiroshima University)
Work history (15)：
  • 2015 - 現在 同准教授
  • 1999 - 2002 Kyoto University Graduate School of Biostudies
  • 1999 - 2002 Graduate School of Bio studies, Kyoto University. Instructor
  • 2002 - - 京都大学大学院生命科学研究科講師
  • 2002 - - Graduate School of Biostudies, Kyoto University, Lecturer
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Committee career (1)：
  • 2019 - 現在 日本免疫学会 評議員
Awards (2)：
  • 2006 - Outstanding Merit Award from International Immunology (筆頭著者)
  • 2004 - Outstanding Merit Award from International Immunology
Association Membership(s) (2)：
日本免疫学会 ,  日本生化学会
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