Rchr

J-GLOBAL ID：200901089274893140 Update date: Sep. 02, 2024

Sugiyama Yuichi

スギヤマユウイチ | Sugiyama Yuichi

Affiliation and department：
Job title： Distinguished professor
Homepage URL (1)： https://www.sugiyamalab-en.com/

Research field (1)： Clinical pharmacy

Research keywords (4)：トランスポーター , 薬物動態 , 生物薬剤学 , Biopharmaceutics

Research theme for competitive and other funds (59)：

2022 - 2025 Integrated development of quantitative prediction methods for transporter mediated complex drug-drug interactions
2022 - 2024 Establishment of a novel methodology for estimating pharmacological target occupancy and therapeutic dosage in Phase I clinical trials for drug development.
2020 - 2023 肝OATP内在性基質の体内動態メカニズム解析による生理学的薬物速度論モデルの確立
2019 - 2022 薬物組織移行・薬効・副作用の支配要因の変動を考慮したバーチャル臨床試験系の確立
2017 - 2021 Database for variation of pharmacokinetic and pharmacodynamic parameters in various diseases

2012 - 2017 Development of quantitative prediction methods for alteration in pharmacokinetics caused by interindividual variability in transporter function and transporter-mediated drug-drug interaction

2008 - 2011 Development of probe drugs for the evaluation of the functions of drug transporters in vivo in humans

2008 - 2009 薬物動態・薬効の変動に関与する薬物トランスポーターの遺伝子多型の包括的実証研究

2008 - 2009 異物解毒システムの個人間変動要因に基づいた抗癌剤処方の最適化戦略の開発

2005 - 2009 Analysis of the function and regulatory mechanism of drug transportsome

2005 - 2007 Development of the quantitative prediction method of pharmacokinetics with considering the function of metabolic enzymes and transporters

2004 - 2004 抗癌剤のテーラーメード医療確立のための異物解毒システムにおける個人差の解明

2003 - 2004 New strategy for the drug development of CNS acting drugs by regulating drug transport across the blood-brain barrier

2000 - 2004 Analysis of the vectorial transport of amino acid and drugs in epithelial cells.

2001 - 2002 Development of the system for prediction of drug-drug interactions in hepatobiliary transport process

2001 - 2002 Drug design based on the substrate specificity of the efflux transporters expressed in the blood-brain barrier

2001 - 2002 肝・腎トランスポーターによる機能分担と活性調節に関する分子シンクロナイゼーション

1999 - 2000 Analysis of the factors governing the elimination route of therapeutic agents

1999 - 2000 肝細胞膜に発現するトランスポーターの分子機能におけるシンクロナイゼーション

1999 - 1999 Metabolic activation of procarcinogens and cancer risk

1998 - 1999 Development of recombinant proteins with an aim to increase their therapeutic activity by the regulation of intracellular sorting

1998 - 1999 Role of hepatic transporters in the detoxification

1997 - 1998 アンチセンスDNAの至適投与法の確立を目指した体内動態、細胞内動態解析法の開発

1997 - 1998 Analysis of molecular basis for the presence of interindividual difference in the biliary excretion of xenobiotics

1997 - 1998 Analysis of multiplicity and polymorphism of drug transporters expressed in the liver.

1997 - 1997 異物解毒の分子基盤:代謝・排泄能の分子から個体への予測

1997 - 1997 受容体介在性機構による遺伝子導入法の速度論的評価(組み換え型ウイルスベクターと非ウイルスベクターの細胞内動態の解析)

1997 - 1997 胆管側膜上有機アニオン輸送担体および関連蛋白とチャンネル機能の協関

1997 - 1997 Role of hepatic transporters in the detoxification

1996 - 1997 Endogenous signal-responsive drug release from bioactive bone cement

1996 - 1997 Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteins

1995 - 1997 A new approach for prediction of clinical efficacy of anticancer drugs based on toxicokinetic and pharmacokinetic analysis

1996 - 1996 薬物解毒(代謝・排泄)能力の予測:分子から個体へ

1996 - 1996 胆管側膜上有機アニオン輸送担体のクローニングとチャンネル機能の構造

1995 - 1996 Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy

1995 - 1996 Clarification of organ specific transport mechanism of druge and its application to regulation of pharmacokinetics and pharmacodynamics

1995 - 1995 抗癌剤の前臨床データを基にしたヒトにおける動態、最大耐用量、抗腫瘍効果の予測

1994 - 1995 Development of drug delivery systems for cytokines with an aim of efficient exertion of their pharmacological effect

1994 - 1995 Drug Delivery to the Brain Using Cell Adhesion Molecule

1994 - 1995 Prediction of hepatobiliary transport of drugs : Contribution of carrier-mediated transport in the detoxication of xenobiotics

1994 - 1994 薬物動態の分子基盤:解毒(代謝・排泄)能力の予測

1994 - 1994 抗癌剤の最適投与計画の作成:骨髄毒性の定量化とその回避

1993 - 1994 Prediction and control effectiveness and safety of a drug by means of pharmacokinetics based on physiological and biochemical mechanism of its disposition in body.

1992 - 1994 A COMPREHENSIVE RESEARCH FOR EXTRAPOLATION--GENETIC HOMOLOGY BETWEEN HUMAN BEINGS AND LABORATORY ANIMALS

1993 - 1993 チトクロームP450を利用したがん原性のシュミレーションと発がんの感受性の解析

1992 - 1993 血液-脳関門における制癌剤透過機構の解明:P-糖蛋白機能発現の定量的評価

1992 - 1993 Development of the drug delivery system for brain and cancer using the inhibitory effect of some drugs on the active efflux : Application of physiological pharmacokinetics.

1992 - 1993 Analysis of drug disposition in the central nervous system based on the transport characteristics across the blood-brain barrier and blood-cerebrospinal fluid barrier : Special focus on Peptide

1992 - 1992 抗癌剤の腫瘍組織へのターゲッティングを目指した組織分布機構の速度論的解明ーP糖蛋白の関与する輸送解析ー

1991 - 1992 抗癌剤の腫瘍組織へのタ-ゲッティングを目指した組織分布機構の速度論的解明

1990 - 1992 Development of intracellular drug delivery system utilizing liposomes

1990 - 1991 Quantitative analysis of Pharmacological effects of psychiatic drugs using neuronal cultured cells

1990 - 1991 Development of a drug delivery system using the receptors located on the cerebral microvessels : An approach based on the physiological pharmacokinetio model.

1990 - 1991 Kinetic analysis of receptor-mediated endocytosis of polypeptide hormones

1988 - 1990 Kinetic Analysis of the CNS Disposition of Drugs in the Renal and Hepatic Failure

1988 - 1989 Quantitative relationship between in vivo receptor occupancy of psychotropic and the change of glucose utilization in brain

1987 - 1988 Pharmacokinetic analysis of disposition of biologically active peptide in the body.

1987 - 1988 Kinetical analysis of pharmacodynamics based on drug-receptor interactions

1984 - 1986 マウスとヒトにおける抗癌剤の比較薬理学的解析

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Papers (645)：

小石川知生, 藤原穫, 前田和哉, 降旗謙一, 杉山雄一, 楠原洋之. 健康成人における腎有機カチオントランスポーターOCT2、MATE1/2-K介在性薬物間相互作用の評価. 日本臨床薬理学会学術総会抄録集. 2024. 44回. 1-C2
Wooin Lee, Min-Soo Kim, Jiyoung Kim, Yasunori Aoki, Yuichi Sugiyama. Predicting in vivo Target Occupancy (TO) Profiles via PBPK-TO Modeling of Warfarin Pharmacokinetics in Blood: Importance of Low Dose Data and Prediction of Stereoselective Target Interactions. Drug metabolism and disposition: the biological fate of chemicals. 2023
Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, A David Rodrigues, Koji Chiba, Hiroyuki Kusuhara, Yuichi Sugiyama. Cluster Gauss-Newton method analyses of PBPK model parameter combinations of coproporphyrin-I based on OATP1B-mediated rifampicin interaction studies. CPT: pharmacometrics & systems pharmacology. 2022. 11. 10. 1341-1357
Maciej J Zamek-Gliszczynski, Vishal Sangha, Hong Shen, Bo Feng, Matthias B Wittwer, Manthena V S Varma, Xiaomin Liang, Yuichi Sugiyama, Lei Zhang, Reina Bendayan. Transporters in Drug Development: International Transporter Consortium Update on Emerging Transporters of Clinical Importance. Clinical pharmacology and therapeutics. 2022. 112. 3. 485-500
Kunal S Taskar, Xinning Yang, Sibylle Neuhoff, Mitesh Patel, Kenta Yoshida, Mary F Paine, Kim L R Brouwer, Xiaoyan Chu, Yuichi Sugiyama, Jack Cook, et al. Clinical Relevance of Hepatic and Renal P-gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective. Clinical pharmacology and therapeutics. 2022. 112. 3. 573-592

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MISC (267)：

屋木祐亮, 木村寛之, 前田和哉, 有光健治, 安井裕之, 杉山雄一, 杉山雄一, 佐治英郎. 有機アニオントランスポーター(OATPs)を標的としたPETイメージングプローブの開発:[¹⁸F]pitavastatinの合成と評価. メディシナルケミストリーシンポジウム講演要旨集. 2017. 35th. 278
Kayoko Kanamitsu, Yoshitane Nozaki, Yoko Nagaya, Yuichi Sugiyama, Hiroyuki Kusuhara. Quantitative prediction of histamine H1 receptor occupancy by the sedative and non-sedative antagonists in the human central nervous system based on systemic exposure and preclinical data (vol 32, pg 135, 2017). DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 4. 228-228
Soo-Jin Kim, Takashi Yoshikado, Ichiro Ieiri, Maeda Kazuya, Miyuki Kimura, Shin Irie, Hiroyuki Kusuhara, Yuichi Sugiyama. THE DRUG-DRUG INTERACTIONS OF CLOPIODGREL FOR OATP1B1 AND CYP2C8: IN VITRO PREDICTION AND A CLINICAL CASSETTE SMALL-DOSE STUDY. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S53-S53
Takashi Yoshikado, Kota Toshimoto, Yuichi Sugiyama. Analysis of drug-drug interactions caused by the inhibition of hepatic organic anion transporting polypeptides using a rational physiologically based pharmacokinetic model and parameters obtained from human hepatocytes. FASEB JOURNAL. 2016. 30
Saki Izumi, Yoshitane Nozaki, Takafumi Komori, Osamu Takenaka, Kazuya Maeda, Hiroyuki Kusuhara, Yuichi Sugiyama. Investigation of fluorescein derivatives as substrates of organic anion transporting polypeptide (OATP) 1B1 to develop sensitive fluorescence-based OATP1B1 inhibition assays. DRUG METABOLISM REVIEWS. 2016. 48. 149-150

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Professional career (2)：

(BLANK) (The University of Tokyo)
(BLANK) (The University of Tokyo)

Work history (8)：

2021/04 - 現在 Josai International University
2012/04 - 2021/03 理化学研究所杉山特別研究室特別招聘研究員
2005 - 2012/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
1997 - 2012/03 The University of Tokyo Graduate School of Pharmaceutical Sciences
2008/04 - 2011/03 (東京大学大学院薬学系研究科長)

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Committee career (7)：

2012/11 - 現在薬物動態談話会会長
2005 - 2007 日本薬物動態学会会長
2005 - 2007 国際薬物動態学会(ISSX) President
2000 - 2004 世界薬学連合(FIP)薬科学部門委員長
2004 - 再生医療学会理事

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Awards (21)：

2014/08 - 経済産業省経済産業大臣賞
2014/03 - ASCPT 2014 Rawls Palmer Progress in Medicine Award
2013/10 - The 2013 R.T. Williams Distinguished Scientific Achievement Award
2012/04 - 米国薬理・治療学会 Bernard B. Brodie 賞
2010/05 - 紫綬褒章

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Association Membership(s) (17)：

CBI学会 , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , 日本くすりと糖尿病学会 , THE JAPANESE SOCIETY FOR ALTERNATIVES TO ANIMAL EXPERIMENTS , JAPANESE SOCIETY OF PHARMACEUTICAL HEALTH CARE AND SCIENCES , THE JAPANESE SOCIETY OF CLINICAL PHARMACOLOGY AND THERAPEUTICS , THE JAPAN SOCIETY OF HEPATOLOGY , 日本臨床腫瘍学会 , THE JAPANESE SOCIETY OF TOXICOLOGY , レギュラトリーサイエンス学会 , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本薬物動態学会 , 国際薬物動態学会(ISSX) , 世界薬学連合(FIP)薬科学部門 , 日本DDS学会 , 日本薬剤学会

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