Suzuki Takayoshi

2020 - 2023 Research on best dosage forms for deglutition disorders

2020 - 2022 Medicinal chemistry targeting epigenetic long noncoding RNAs

2016 - 2021 Development of inhibitors that stablize the transition state of enzymatic reactions

2017 - 2020 Design, synthesis and biological activity of SIRT7 inhibitors

2016 - 2019 Novel small-molecule sirtuin inhibitors induce cell apoptic death in leukemia cells

2016 - 2018 CH活性化反応を利用したエピジェネティクス制御化合物の創製

2016 - 2018 Elucidation of epigenome-mediated proliferation mechanism in bladder cancer and development of therapy with novel inhibitors

2016 - 2018 Development of platform for cancer epigenetic therapy by region-specific inhibition of epigenomic alteration

2015 - 2017 Discovery of demethylase/deacetylase modulators towards therapy for hereditary diseases

2014 - 2017 SIRT7阻害薬の創製研究

2014 - 2017 Selective modification of histone methylation using DNA binding-small molecules

2014 - 2016 Identification of a novel tumor-associated protein in gliomagenesis and chemicals targeting its function.

2013 - 2016 Development of drug-resistance-overcoming agents targeting histone demethylase JARID1A

2012 - 2015 Discovery of drug candidates by using in situ click chemistry

2012 - 2015 Novel small-molecule SIRT1 inhibitors induce cell death in leukaemia cells

2012 - 2015 HDAC2選択的阻害薬の創製

2011 - 2013 Basic and applied research of CH-O interaction

2010 - 2012 Oxidative stress imaging in organelle by novel TEMPO derivatives

2008 - 2011 Development of drug candidates that epigenetically regulate gene expression

2005 - 2008 Oxidative degeneration of neurodegenerative disease-related protein and reactive nitrogen oxide stress

2005 - 2006 ヒストンのアセチル化により遺伝子発現を制御するリガンドの創製と医薬への応用

2002 - 2005 Development of novel oxyl-radical quenching pharmacophores as drug candidates

エビジェネティクス制御化合物の合成と応用