Ohtani Kiyoshi

オオタニキヨシ | Ohtani Kiyoshi

Affiliation and department：
Job title： Professor

Research field (4)： Tumor biology , Virology , Cell biology , Molecular biology

Research keywords (9)： RB/E2F , がん化抑制機構 , がん化機構 , ウイルス発癌 , 転写制御 , 細胞周期制御 , Viral Oncogenesis , Transcriptional Regulation , Cell Cycle Regulation

Research theme for competitive and other funds (6)：

HTLV-Iによる発癌機序
E2Fの新しい標的遺伝子の同定
細胞周期制御
Oncogenesis by HTLV-I
Functional analyses of new E2F target genes and distinct transcriptional regulation mediated by E2F

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Papers (36)：

Mashiro Shirasawa, Rinka Nakajima, Yaxuan Zhou, Lin Zhao, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P. Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani. Activation of the CDK7 Gene, Coding for the Catalytic Subunit of the Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) and General Transcription Factor II H, by the Trans-Activator Protein Tax of Human T-Cell Leukemia Virus Type-1. Genes. 2024. 15. 8. 1080-1080
Rahma F Hayati, Rinka Nakajima, Yaxuan Zhou, Mashiro Shirasawa, Lin Zhao, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P Bradford, Kenta Kurayoshi, Keigo Araki, et al. Trans-Activation of the Coactivator-Associated Arginine Methyltransferase 1 (Carm1) Gene by the Oncogene Product Tax of Human T-Cell Leukemia Virus Type 1. Genes. 2024. 15. 6
Yaxuan Zhou, Rinka Nakajima, Mashiro Shirasawa, Mariana Fikriyanti, Lin Zhao, Ritsuko Iwanaga, Andrew P Bradford, Kenta Kurayoshi, Keigo Araki, Kiyoshi Ohtani. Expanding Roles of the E2F-RB-p53 Pathway in Tumor Suppression. Biology. 2023. 12. 12
Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Arlene Angelina, Yasuko Goto, Fumiya Tohjo, Kengo Nakahashi, et al. The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F. Biochemical and biophysical research communications. 2023. 663. 154-162
Rinka Nakajima, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Ayato Uchida, Hikaru Murakawa, Mariana Fikriyanti, Ritsuko Iwanaga, Andrew P Bradford, Keigo Araki, et al. Deregulated E2F Activity as a Cancer-Cell Specific Therapeutic Tool. Genes. 2023. 14. 2

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MISC (35)：

Hisao Masai, Chika Taniyama, Keiko Ogino, Etsuko Matsui, Naoko Kakusho, Seiji Matsumoto, Jung-Min Kim, Ai Ishii, Taku Tanaka, Toshiko Kobayashi, et al. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. The Journal of biological chemistry. 2006. 281. 51. 39249-61
R Iwanaga, H Komori, S Ishida, N Okamura, K Nakayama, KI Nakayama, K Ohtani. Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners. ONCOGENE. 2006. 25. 12. 1786-1798
Hideyuki Komori, Mitsuru Enomoto, Masataka Nakamura, Ritsuko Iwanaga, Kiyoshi Ohtani. Distinct E2F-mediated transcriptional program regulates p14ARF gene expression. The EMBO journal. 2005. 24. 21. 3724-36
Ritsuko Iwanaga, Hideyuki Komori, Kiyoshi Ohtani. Differential regulation of expression of the mammalian DNA repair genes by growth stimulation. Oncogene. 2004. 23. 53. 8581-90
N Funato, K Ohtani, K Ohyama, T Kuroda, M Nakamura. Common regulation of growth arrest and differentiation of osteoblasts by helix-loop-helix factors. MOLECULAR AND CELLULAR BIOLOGY. 2001. 21. 21. 7416-7428

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Professional career (1)：

Doctor of Medicine (Tohoku University)

Work history (4)：

2009/04 - 現在関西学院大学教授
1997/04 - 2009/03 東京医科歯科大学講師
1992/04 - 1996/03 米国Duke大学Howard Hughes医科学研究所研究員
1989/04 - 1992/03 Tohoku University Faculty of Medicine

Association Membership(s) (2)：

分子生物学会 , 癌学会

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