Research keywords (1)：
ミスマッチ結合分子 SNP検出 ドラッグの分子設計 核酸ードラッグ複合体 トリプレットリピート
Research theme for competitive and other funds (45)：
2022 - 2025 Elucidation of the binding pathway of mismatch-binding molecules to abnormally elongated repeat sequences and their shortening-inducing effects
2019 - 2022 Challenge in computational science toward the identification of the reaction pathway for the formation of nucleic acids-small molecule complexes
2019 - 2022 リピート配列を特異的に化学修飾するリピート結合分子の創成
2016 - 2019 Development of novel microRNA detection system
2014 - 2019 Chemical Biology Studies on Trinucleotide Repeat Disease using Repeat-Binding Molecules
Shuhei Sakurabayashi, Takeshi Yamada, Kazuhiko Nakatani. The heterodimer of 2-amino-1,8-naphthyridine and 3-aminoisoquinoline binds to the CTG/CTG triad via hydrogen bonding. Bioorganic & Medicinal Chemistry Letters. 2024. 129985-129985
Lu Ni, Takeshi Yamada, Kazuhiko Nakatani. Utility of oligonucleotide in upregulating circular RNA production in a cellular model. 2024
Takeshi Yamada, Shuhei Sakurabayashi, Noriaki Sugiura, Hitoshi Haneoka, Kazuhiko Nakatani. NMR analysis of 15N-labeled naphthyridine carbamate dimer (NCD) to contiguous CGG/CGG units in DNA. Chemical Communications. 2024
Qingwen Chen, Takeshi Yamada, Asako Murata, Ayako Sugai, Yasuyuki Matsushita, Kazuhiko Nakatani. A machine learning approach toward generating the focused molecule library targeting CAG repeat DNA. Digital Discovery. 2024
Eitaro Murakami, Masayuki Nakamori, Kazuhiko Nakatani, Tomonori Shibata, Kazuki Tainaka. Intracerebral Distribution of CAG Repeat-Binding Small Molecule Visualized by Whole-Brain Imaging. Bioconjugate chemistry. 2023. 34. 12. 2187-2193
