Hori Yuichi

ホリユウイチ | Hori Yuichi

Affiliation and department：
Job title： Professor

Research field (1)： Digestive surgery

Research keywords (6)： Exosome , regenerative medicine , pancreatic cancer , diabetes mellitus , cancer stem cell , tissue stem cell

Research theme for competitive and other funds (22)：

2023 - 2026 Elucidation of the pathogenic mechanism of de-differentiation into pancreatic adenocytes in diabetic pancreatic beta cells.
2021 - 2024 Establishment of organoid culture method to reconstruct neural invasion of pancreatic cancer cells
2021 - 2024 The mechanism of promoting remote metastasis by exosome derived from pancreatic cancer
2020 - 2023 ワークファミリーバランスを高める保育と地域・職域保健の連携・支援システムの開発
2020 - 2023 日本人2型糖尿病感受性遺伝子GCN2が膵β細胞機能に及ぼす影響に関する検討

2018 - 2021 Pancreatic cancer derived exosomes promote early liver metastasis

2017 - 2020 Establishment of novel target therapy for K-ras/MMP-10 signaling pathway in chemotherapy-resistant pancreatic cancer

2015 - 2018 Targeting strategy to inhibit liver metastasis for pancreatic cancer

2014 - 2017 Reconstruction of pancreatic cancer microenvironment

2017 - AMED 標的分子の臨床エビデンス取得

2012 - 2015 Study of resistant mechanism to chemotherapeutic agents of CD133 expression in biliary tract cancers

2012 - 2015 Reconstitution of microenvironment surrounding pancreatic cancer

2011 - 2014 尾側膵切除における術前内視鏡的膵管ステント留置術の有用性

2011 - 2014 ヒトCD133陽性膵癌幹細胞を用いた新規膵癌治療薬の開発

2010 - 2013 肝門部胆管癌に対する吸収性スペーサーを用いた手術と粒子線による2段階治療

2011 - 2013 Targeting therapy using chemotherapy-resistant pancreatic cancer stem cells

2011 - 2013 The effect of prophylactic preoperative endoscopic transpapillary pancreatic stenting on clinically significant pancreatic fistula following distal pancreatectomy

2009 - 2011 Isolation of adult pancreatic stem cells for regenerative medicine of diabetes mellitus

2006 - 2010 Establishment of simultaneous islet cell and pancreas transplantation from a splitting single-donor pancreas

2005 - 2006 Research of the isolation of pancreatic stem / progenitor cells for the treatment of diabetes mellitus

1999 - 2000 Mechanism for Immunosuppression in Acute Pancreatitis

1996 - 1997 INVOLVEMENT OF APOPTOSIS IN ORGAN FAILURE WITH SEVER ACUTE PANCREATITIS

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Papers (197)：

Exosomes in ascites from patients with human pancreatic cancer enhance remote metastasis partially through endothelial-mesenchymal transition. Pancreatology. 2023. 23. 377-388
Fumiya Nakayama, Makoto Miyoshi, Ai Kimoto, Akari Kawano, Kumoko Miyashita, Shingo Kamoshida, Kazuya Shimizu, Yuichi Hori. Pancreatic cancer cell-derived exosomes induce epithelial-mesenchymal transition in human pancreatic cancer cells themselves partially via transforming growth factor β1. Medical Molecular Morphology. 2022
Akari Kawano, Kazuya Shimizu, Makoto Miyoshi, Kumiko Miyashita, Yume Terada, Mion Wakita, Aya Oshimo, Hiroshi Takashima, Yuichi Hori. Exosomes from pancreatic cancer cells promote distant metastasis due to injured vascular endothelial cells. CANCER SCIENCE. 2021. 112. 493-493
Makoto Miyoshi, Hiraku Kadoguchi, Makoto Usami, Yuichi Hori. Synbiotics improved stool form via changes in the microbiota and short-chain fatty acids in hemodialysis patients. Kobe Journal of Medical Sciences. 2021
Miyoshi M, Shiroto A, Kadoguchi H, Usami M, Hori Y. Prebiotics improved the defecation status via changes in the microbiota and short-chain fatty acids in hemodialysis patients. Kobe Journal of Medical Sciences. 2020. 66. 1. E12-E21

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MISC (58)：

村上冴, 味木徹夫, 堀裕一, 篠崎健太, 吉田優子, 大坪出, 岡崎太郎, 松本逸平, 福本巧, 具英成. YT-6-5(YRA) 粘液産生胆管腫瘍(IPNB)からの細胞株樹立(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会). 日本外科学会雑誌. 2013. 114. 2. 405-405
Yuichi Hori, Kazuya Shimizu, Sachie Chiba. Direct interaction between human pancreatic cancer stem cells and stromal cells remodels extracellular matrix formation for cancer stem cell niche. CANCER RESEARCH. 2012. 72
浦出剛史, 木戸正浩, 福本巧, 堀裕一, 楠信也, 土田忍, 高橋応典, 田中基文, 蔵満薫, 津川大介, et al. 肝切除および粒子線治療併用にて治療効果を認めた両葉多発肝細胞癌の1例. 癌と化学療法. 2011. 38. 12. 2065-2067
松本逸平, 白川幸代, 新関亮, 外山博近, 浅利貞毅, 後藤直大, 山下博成, 田中正樹, 木戸正浩, 楠信也, et al. 嚢胞成分を伴い診断困難であったStage I浸潤性膵管癌の1例. 膵臓. 2011. 26. 4. 511-516
沢秀博, 味木徹夫, 山田勇, 上野公彦, 大坪出, 後藤直大, 浅利貞毅, 新関亮, 外山博近, 木戸正浩, et al. PS-098-7 胆管癌における肝外胆管切除症例の検討(PS-098 ポスターセッション(98)胆管:悪性-1,第111回日本外科学会定期学術集会). 日本外科学会雑誌. 2011. 112. 1. 675-675

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Books (10)：

新膵臓病学「インスリノーマ」
南江堂 2017
Prominin-1 (CD133) reveals new faces of pancreatic progenitor cells and cancer stem cells: current knowledge and therapeutic perspectives
Springer 2013
前腸系ステム細胞膵臓組織幹細胞と膵での病変、病態との関連性
肝胆膵 2013
肝・胆道系症候群 / 境界領域型腺腫様過形成
日本臨床 2010
肝胆膵肝胆膵領域における幹細胞研究の最前線 / 膵組織幹細胞
アークメディア 2009

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Lectures and oral presentations (46)：

抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析
(第50回日本臨床分子形態学会総会・学術集会 2018)
抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立とその解析
(第49回日本膵臓学会大会 2018)
抗がん剤耐性膵癌細胞ではヒストンアセチル化を介したKras-MEK-Matrix Metalloproteinase-10シグナルがGemcitabine投与で増強する
(第40回日本分子生物学会 2017)
抗がん剤Gemcitabine耐性マウス膵癌細胞の樹立と解析
(第40回日本分子生物学会 2017)
がん遺伝子を導入したマウス膵臓組織幹細胞はがん幹細胞様の表現型を示す
(第40回日本分子生物学会 2017)

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Education (3)：

2000 - 2003 Stanford University School of Medicine Medicine Department of Developmental Biology
1988 - 1992 Kobe University Grad. School of Medicine
1980 - 1986 Kobe University School of Medicine

Professional career (1)：

博士(医学) (神戸大学)

Work history (11)：

2013/10 - 現在 Kobe University Graduate School of Health Sciences Department of Biophysics Professor
2011/04 - 2013/09 Kobe University Graduate School of Health Sciences Department of Biophysics Associate Professor
2008/04 - 2011/03 Kobe University Graduate School of Medicine Hepato-Biliary-Pancreatic Surgery
2004/01 - 2008/03 Kobe University Graduate School of Medicine 21th Century, Center of Excellence Program Senior scientist
2000/09 - 2003/12 Stanford University School of Medicine Postdoc

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Committee career (4)：

日本膵臓学会学会評議員
近畿外科学会学会評議員
日本臨床分子形態学会学会評議員
日本消化器病学会学会評議員

Awards (6)：

2011/09 - 日本臨床分子形態学会 The Japanese Society for Clinical Molecular Morphology, Excellent Paper Award for 2010 Excellent Paper Award for 2010
2010/11 - 日本消化器病学会 The 1st Japanese Society of Gastroenterology, International Topic Conference, “Stem Cells in Digestive Organs” Poster Award “Stem Cells in Digestive Organs” Poster Award
2009/10 - 神戸大学大学院医学研究科平成20年度神戸大学医学部優秀学術論文賞 Enrichment of putative pancreatic progenitor cells from mice by sorting for prominin1 (CD133) and platelet-derived growth factor receptor b. Stem Cells, 26:2912-2920, 2008.
2004/08 - Juvenile Diabetes Research Foundation International (JDRF) Advanced Postdoctoral Reserch Fellowship Islet Replacement Strategies for Stem Cells
2001/09 - Stanford University School of Medicine Walter V. and Idun Berry Fellowship Award Islet replacement strategies for embryonic stem cells

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Association Membership(s) (11)：

国際膵臓学会 , アメリカ癌学会 , 日本分子生物学会 , 日本臨床分子形態学会 , 日本肝臓学会 , 日本糖尿病学会 , 日本癌学会 , 日本膵臓学会 , 日本外科学会 , 日本消化器外科学会 , 日本消化器病学会

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