Rchr
J-GLOBAL ID：200901090925434555   Update date: Sep. 23, 2024

Oku Naoto

オク ナオト | Oku Naoto
Affiliation and department：
Teikyo University Faculty of Pharma-Science

About Teikyo University Faculty of Pharma-Science


Research field  (2)： Clinical pharmacy ,  Pharmaceuticals - health and biochemistry
Research keywords  (5)： Drug Delivery System ,  Life Science ,  drug delivery Systems ,  Radiobiochemistry ,  Medical biochemistry
Research theme for competitive and other funds  (39)：
  • 2022 - 2025 Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
  • 2022 - 2024 持続的な培地回収システムを用いた高機能エクソソームの探索と薬物送達への応用
  • 2019 - 2022 Development of plastic antibodies that inhibit intestinal absorption of target molecules
  • 2016 - 2020 Development of new eye drop treatment using liposomal delivery system for age-related macular degeneration.
  • 2015 - 2020 Experimental approach to respiratory and circulatory failure using artificial oxygen carriers and their derivatives
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Papers (288)：
  • Hiroyuki Koide, Chiaki Kiyokawa, Anna Okishima, Kaito Saito, Keiichi Yoshimatsu, Tatsuya Fukuta, Yu Hoshino, Tomohiro Asai, Yuri Nishimura, Yoshiko Miura, et al. Design of an Anti-HMGB1 Synthetic Antibody for In Vivo Ischemic/Reperfusion Injury Therapy. Journal of the American Chemical Society. 2023
  • Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Beverly Chou, Yu Hoshino, Sei Yonezawa, Naoto Oku, Tomohiro Asai, Kenneth J Shea. Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy. Journal of controlled release : official journal of the Controlled Release Society. 2023. 355. 745-759
  • Tomohiro Asai, Masafumi Yokota, Hideki Isomura, Hiroyuki Koide, Naoyuki Sakurai, Ayaka Okamoto, Hidenori Ando, Takehisa Dewa, Naoto Oku. Treatment of PTEN-Null Breast Cancer by a Synthetic Lethal Approach Involving PARP1 Gene Silencing. Journal of pharmaceutical sciences. 2023
  • Hiroyuki Koide, Hiroki Ochiai, Hikaru Suzuki, Shinya Hirata, Midori Watanabe, Sei Yonezawa, Takehisa Dewa, Naoto Oku, Tomohiro Asai. Easy preparation of a liposome-mediated protein delivery system by freeze-thawing a liposome-protein complex. Journal of materials chemistry. B. 2022. 10. 35. 6768-6776
  • 小出 裕之, 米澤 正, 出羽 毅久, 奥 直人, 浅井 知浩. 社会のアンメットニーズに応えるDDS 凍結融解技術を駆使した核酸・タンパク質送達方法の開発. 日本DDS学会学術集会プログラム予稿集. 2022. 38回. 74-74
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MISC (303)：
  • 渡邊翠, 小出裕之, 平田真也, 米澤正, 出羽毅久, 奥直人, 奥直人, 浅井知浩. Development of protein delivery strategy using multi-functionalized liposomes. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
  • Satoshi Hirano, Hiroyuki Koide, Takahumi Ide, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai. Design of multi-functionalized liposomes for adsorbing and neutralizing target molecules in vivo. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019. 258
  • Hiroyuki Koide, Yu Hoshino, Yuri Nishimura, Yoshiko Miura, Naoto Oku, Kenneth Shea, Tomohiro Asai. Development of a plastic antibody that captures vascular endothelial growth factor (VEGF) for anticancer therapy. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019. 258
  • Ayaka Masuda, Hiroyuki Koide, Hiromichi Egami, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai. Development of polymer nanoparticles adsorbing alpha-glucosidase for diabetes treatment. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2019. 258
  • 清水広介, 奥直人. Advantages of antibody usage in liposomal DDS for cancer chemotherapy. Drug Delivery System. 2019. 34. 1. 22-28
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Patents (30)：
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Books (19)：
  • Shimizu K, Oku N: "Liposomes conjugated with a pilot molecule." pp. 187-216.
    “Cancer drug delivery systems based on the tumor microenvironment.” (Matsumura Y, Tarin D. eds.) Springer Japan. 2019
  • Koide H, Asai T, Shimizu K, Oku N: "Drug carrier systems for anticancer agents." pp. 153-169.
    “Polymeric Biomaterials: Medical and Pharmaceutical Applications, Volume 2” (Dumitriu S, Popa V. Eds.) CRC Press, Taylor and Francis Group, Boca Raton, FL. 2013
  • Shimizu K, Oku N: "Brain tumor diagnosis using PET with angiogenic vessel-targeting liposomes." pp. 169-176.
    “Tumor of the central nervous system, Volume 3” (Hayat MA. ed.) Springer, New York, NY. 2011
  • Asai T, Oku N: "Angiogenic vessel-targeting DDS by liposomalized oligapeptides." pp.335-347.
    “Liposomes Methods and Protocols, Volume 1: Pharmaceutical Nanocarriers” (Weissig V. ed.) Methods in Molecular Biology 605, Humana Press, Totowa, NJ 2010
  • Oku N, Ishii T: "Antiangiogenic Photodynamic Therapy with Targeted Liposomes." pp. 313-330.
    “Liposomes, Part G” (Düzgüneș N. ed.) Methods in Enzymology 465, Elsevier Academic Press, San Diego CA. 2009
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Education (2)：
  • 1975 - 1980 The University of Tokyo Graduate School of Pharmaceutical Sciences
  • 1971 - 1975 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
  • Ph.D (University of Tokyo)
Work history (15)：
  • 2018/04 - 現在 Teikyo University Faculty of Pharma-Science
  • 1998 - 2018 University of Shizuoka School of Pharmaceutical Sciences
  • 1991 - 1998 University of Shizuoka School of Pharmaceutical Sciences
  • 1991 - 1998 Associate Professor University of Shizuoka
  • 1998 - - Professor University of Shizuoka
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Committee career (3)：
  • 日本学術会議 連携会員
  • 薬学教育評価機構 副理事長
  • NPO法人薬学共用試験センター 理事長
Awards (5)：
  • 2019/09 - Liposome Research Days The Alec D. Bangham, MD, FRS Achievement Award for Lifetime Contributions in Liposome Researvch
  • 2016 - 日本薬学会賞 受賞
  • 2015 - 日本薬剤学会タケル・アヤ・ヒグチ記念賞 受賞
  • 2012 - 日本DDS学会永井賞 受賞
  • 1995 - 日本薬学会奨励賞 受賞
Association Membership(s) (5)：
日本薬学教育学会 ,  Control Release Society ,  国際リポソーム学会 ,  日本DDS学会 ,  日本薬学会
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