Onaka Hiroyasu

オナカヒロヤス | Onaka Hiroyasu

Affiliation and department：
Job title：特任教授
Homepage URL (2)： http://microbial-potential.bt.a.u-tokyo.ac.jp/ , http://microbial-potential.bt.a.u-tokyo.ac.jp/en/

Research field (5)： Pharmacology , Pharmaceuticals - health and biochemistry , Applied biochemistry , Applied microbiology , Molecular biology

Research keywords (9)：生合成 , 抗生物質 , 放線菌 , Biosynthesis , genetics , Streptomyces , Actinomycetes , Secondary metabolism , Antibiotics

Research theme for competitive and other funds (17)：

2021 - 2025 リボソーム翻訳後修飾ペプチド天然物の構造多様性拡張
2021 - 2024 Using terpenes as a key to unlock "Black box" of microbial interactions in subseafloor
2018 - 2021 the mode of action in the combined-culture methods that induce potential secondary metabolism
2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
2013 - 2017 Secondary metabolite Screening by combined-culture

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Papers (110)：

Yukun Lei, Hiroyasu Onaka, Shumpei Asamizu. Transcriptionally induced nucleoid-associated protein-like ccr1 in combined-culture serves as a global effector of Streptomyces secondary metabolism. Frontiers in microbiology. 2024. 15. 1422977-1422977
Shotaro Hoshino, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka. Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan. Journal of the American Chemical Society. 2023
Fumihiro Ishikawa, Natsumi Tsukumo, Erika Morishita, Shumpei Asamizu, Saaya Kusuhara, Shinsuke Marumoto, Katsuki Takashima, Hiroyasu Onaka, Genzoh Tanabe. Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains. Chemical communications (Cambridge, England). 2023. 59. 62. 9473-9476
Shinta Ijichi, Shotaro Hoshino, Shumpei Asamizu, Hiroyasu Onaka. SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins. Bioorganic & medicinal chemistry letters. 2023. 129323-129323
Yukun Lei, Shumpei Asamizu, Takumi Ishizuka, Hiroyasu Onaka. Regulation of Multidrug Efflux Pumps by TetR Family Transcriptional Repressor Negatively Affects Secondary Metabolism in Streptomyces coelicolor A3(2). Applied and environmental microbiology. 2023. 89. 3. e0182222

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MISC (69)：

LEI Yukun, 浅水俊平, 尾仲宏康. Analysis of a gene involved in secondary metabolism fully conserved in Streptomyces species. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
河野佐知子, 浅水俊平, 尾仲宏康. Analysis on mechanism of action of goadsporin, a peptide antibiotic targeting growth, secondary metabolism, and sporulation in actinomycetes. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
加藤愛美, 浅水俊平, 浅水俊平, 尾仲宏康, 尾仲宏康. Investigation of novel Streptomyces branching inducer. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
加藤愛美, 浅水俊平, 尾仲宏康. pyrogallol induced bump structure in Streptomyces cells. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
木田優士, 浅水俊平, 尾仲宏康. RNA-seq based analysis of mechanism responsible for activation of secondaty metabolism in combined-culture. 日本農芸化学会大会講演要旨集(Web). 2021. 2021

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Education (2)：

Professional career (1)：

Awards (3)：

Association Membership(s) (2)：

日本放線菌学会 , 日本農芸化学会

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