Rchr
J-GLOBAL ID：200901091253467367
Update date: Apr. 26, 2024
Onaka Hiroyasu
オナカ ヒロヤス | Onaka Hiroyasu
Affiliation and department：
Job title：
特任教授
Homepage URL (2)：
http://microbial-potential.bt.a.u-tokyo.ac.jp/
,
http://microbial-potential.bt.a.u-tokyo.ac.jp/en/
Research field (5)：
Pharmacology
, Pharmaceuticals - health and biochemistry
, Applied biochemistry
, Applied microbiology
, Molecular biology
Research keywords (9)：
生合成
, 抗生物質
, 放線菌
, Biosynthesis
, genetics
, Streptomyces
, Actinomycetes
, Secondary metabolism
, Antibiotics
Research theme for competitive and other funds (17)：
- 2021 - 2025 リボソーム翻訳後修飾ペプチド天然物の構造多様性拡張
- 2021 - 2024 Using terpenes as a key to unlock "Black box" of microbial interactions in subseafloor
- 2018 - 2021 the mode of action in the combined-culture methods that induce potential secondary metabolism
- 2016 - 2021 Synthetic biology of pseudo-natural products by artificial in vitro biosynthesis
- 2013 - 2017 Secondary metabolite Screening by combined-culture
- 2013 - 2015 翻訳系複素環ペプチド生合成遺伝子群の覚醒と新奇抗生物質生産システムへの適応
- 2011 - 2013 翻訳系を介した複素環含有ペプチド生合成機構を応用した抗生物質生産システムの構築
- 2010 - 2012 Characterization of indolocarbazole biosynthetic enzymes; for the application to
- 2008 - 2010 Expression of microbial enzymes in aquatic plants and their applications for phytoremediation and production of useful chemicals.
- 2006 - 2010 混合培養とコンビナトリアル生合成技術を核とした新規生理活性物質スクリーニング法の確立に関する研究
- 2005 - 2006 放線菌由来インドロカルバゾール生合成研究及び新規物質創製への展開
- 2002 - 2004 放線菌が生産するインドロカルバゾール化合物の生合成に関する研究
- 2000 - 2001 放線菌の生産するスタウロスポリンの生合成に関する研究
- 放線菌の二次代謝誘発物質に関する研究
- インドロカルバゾール生合成に関する研究
- Studies on Secondary metabolism inducers in Streptomyces
- Studies on indolocarbazole biosynthesis in Actinomycetes
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Papers (109)：
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Shotaro Hoshino, Shinta Ijichi, Shumpei Asamizu, Hiroyasu Onaka. Insights into Arsenic Secondary Metabolism in Actinomycetes from the Structure and Biosynthesis of Bisenarsan. Journal of the American Chemical Society. 2023
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Fumihiro Ishikawa, Natsumi Tsukumo, Erika Morishita, Shumpei Asamizu, Saaya Kusuhara, Shinsuke Marumoto, Katsuki Takashima, Hiroyasu Onaka, Genzoh Tanabe. Biosynthetic diversification of non-ribosomal peptides through activity-based protein profiling of adenylation domains. Chemical communications (Cambridge, England). 2023. 59. 62. 9473-9476
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Shinta Ijichi, Shotaro Hoshino, Shumpei Asamizu, Hiroyasu Onaka. SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins. Bioorganic & medicinal chemistry letters. 2023. 129323-129323
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Yukun Lei, Shumpei Asamizu, Takumi Ishizuka, Hiroyasu Onaka. Regulation of Multidrug Efflux Pumps by TetR Family Transcriptional Repressor Negatively Affects Secondary Metabolism in Streptomyces coelicolor A3(2). Applied and environmental microbiology. 2023. 89. 3. e0182222
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Manami Kato, Shumpei Asamizu, Hiroyasu Onaka. Redox-active compound generated by bacterial crosstalk induces hypha branching inStreptomycesspecies. 2023
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MISC (69)：
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LEI Yukun, 浅水俊平, 尾仲宏康. Analysis of a gene involved in secondary metabolism fully conserved in Streptomyces species. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
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河野佐知子, 浅水俊平, 尾仲宏康. Analysis on mechanism of action of goadsporin, a peptide antibiotic targeting growth, secondary metabolism, and sporulation in actinomycetes. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
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加藤愛美, 浅水俊平, 浅水俊平, 尾仲宏康, 尾仲宏康. Investigation of novel Streptomyces branching inducer. 日本農芸化学会大会講演要旨集(Web). 2022. 2022
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加藤愛美, 浅水俊平, 尾仲宏康. pyrogallol induced bump structure in Streptomyces cells. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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木田優士, 浅水俊平, 尾仲宏康. RNA-seq based analysis of mechanism responsible for activation of secondaty metabolism in combined-culture. 日本農芸化学会大会講演要旨集(Web). 2021. 2021
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Education (2)：
- - 1993 The University of Tokyo
- - 1993 The University of Tokyo Faculty of Agriculture
Professional career (1)：
- Ph.D (The University of Tokyo)
Awards (3)：
- 2008 - 日本農芸化学会奨励賞
- 2005 - 日本放線菌学会浜田賞
- 2004 - 日本農芸化学会BBB論文賞
Association Membership(s) (2)：
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