Hoshino Tyuji

ホシノチュウジ | Hoshino Tyuji

Affiliation and department：
Job title： Associate Professor
Homepage URL (2)： https://www.p.chiba-u.jp/lab/riron/index.html , https://www.p.chiba-u.jp/lab/riron/index-e.html

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research theme for competitive and other funds (25)：

2023 - 2026 mTORシグナリング経路の新規動態解析と関連する抗がん剤開発
2023 - 2026 核小体内におけるRNA polymerase IIによるribosomal RNAの転写と癌化機構の解明
2022 - 2025 単一NVセンター配列を用いたタンパク質の1分子量子計測
2021 - 2025 In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬
2021 - 2024 Development of inhibitors targeting enzymatic activity of SARS-CoV-2 proteases

2020 - 2023 がん細胞のリボソーム構成タンパク質の発現解析と転写後調節への関与

2019 - 2023 HLA多型の構造的特徴に基づく皮膚特異的な過敏症リスク薬物の評価系構築

2018 - 2021 Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method

2018 - 2021 Development of Inhibitors for Influenza Endonuclease Activity

2017 - 2021 Establishment of detection methods of early cancers with chronic inflammation by non-viral mechanism

2017 - 2020 Developing a novel method of optically detected magnetic resonance measurement method for pharmaceutical application

2015 - 2018 Development of Inhibitors for Metallo-beta-lactamases

2014 - 2017 Development of a novel mechanism of T-ALL and its clinical application for the diagnosis and treatment.

2014 - 2017 Structure basis of reaction mechanism of beta-lactamases and new inhibitor search

2012 - 2015 Develpoment of inhibitors for endo-nuclease activity of influenza viruses

2010 - 2014 Ultra high resolution Xray crystallographic study for antibiotic mechanisms of action and resistance

2009 - 2011 Development of anti-HIV agents for the viral variants

2008 - 2010 Development of novel cancer diagnosis and treatment targeting splicing variants of c-myc transcriptional suppressor FIR

2008 - 2010 膜タンパク質の生体膜上での挙動解析に関する計算技法の開発

2007 - 2009 Search, asymmetric synthesis, and medicinal chemistry study on the plant alkaloids that regulate the brain nervous system.

2007 - 2008 Development of anti-HIV chemicals effective for the virus conferring drug resistance

2007 - 2008 薬物代謝酵素シトクロームp450の反応解析と計算機代謝能予測システムの開発

1999 - 2000 半導体固体表面の構造相転移に対する応力の影響の理論的解析

1997 - 1998 HIV-1プロテアーゼの作用機構の解明

1993 - 1996 Doping by single Ion Implantation and its application to solid state materials and devices.

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Papers (142)：

Taichi Kamo, Keiichi Kuroda, Saki Nimura, Yan Guo, Shota Kondo, Michiyoshi Nukaga, Tyuji Hoshino. Development of Inhibitory Compounds for Metallo-beta-lactamase through Computational Design and Crystallographic Analysis. Biochemistry. 2024. 63. 10. 1278-1286
Kouichi Kitamura, Tyuji Hoshino, Atsushi Okabe, Masaki Fukuyo, Bahityar Rahmutulla, Nobuko Tanaka, Sohei Kobayashi, Tomoaki Tanaka, Takashi Shida, Mashiro Ueda, et al. The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer. International journal of molecular sciences. 2023. 24. 24
Kazunori Miwa, Yan Guo, Masayuki Hata, Yoshinori Hirano, Norio Yamamoto, Tyuji Hoshino. <i>In Silico</i> Identification of Inhibitory Compounds for SARS-Cov-2 Papain-Like Protease. Chemical and Pharmaceutical Bulletin. 2023. 71. 12. 897-905
Yuma Ito, Huiyan Lu, Mariko Kitajima, Hayato Ishikawa, Yoshihiro Nakata, Yasumasa Iwatani, Tyuji Hoshino. Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase. Journal of natural products. 2023. 86. 11. 2487-2495
Sohei Kobayashi, Takaki Hiwasa, Kouichi Kitamura, Masayuki Kano, Tyuji Hoshino, Sho Hirano, Mayuko Hashimoto, Masanori Seimiya, Hideaki Shimada, Fumio Nomura, et al. Combinational antibody detection approach increases the clinical validity of colorectal cancer screening. Journal of clinical laboratory analysis. 2023. e24978

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MISC (281)：

鵜沼春菜, 志田隆史, 植田真白, 小林崇平, 星野忠次, 松下一之, 松下一之. FIR Δ exon2を選択的に阻害する分子化合物BK697は肝癌細胞の増殖を抑制する. 医療検査と自動化(Web). 2021. 46. 4
Kobayashi Sohei, Kobayashi Sohei, Hiwasa Takaki, Ishige Takayuki, Kano Masayuki, Hoshino Tyuji, Rahmutulla Bahityar, Seimiya Masanori, Shimada Hideaki, Nomura Fumio, et al. Anti-FIRΔexon2 autoantibody as a novel indicator for better overall survival in gastric cancer. Cancer Science (Web). 2021. 112. 2
宮地秀明, 松岡悠美, 松江弘之, 星野忠次, 宇津野恵美, 松下一之, 橋村知波, 堀内孝彦. 遺伝性血管性浮腫の新規遺伝子変異分子動力学シミュレーションを用いた立体構造解析による病原性の検討. 日本皮膚科学会雑誌. 2019. 129. 4. 595-596
渡邉賢治, 青木重樹, 後藤貴博, QU Liang, 星野忠次, 伊藤晃成. In silico手法を利用した特異体質薬物毒性に関与するHLA多型の構造的解析. 日本免疫毒性学会学術年会講演要旨集. 2018. 25th
松下一之, 星野忠次, 西村基, 北村浩一, 小林崇平, グザヌルアリキン, 田中信子. c-Myc制御,DNA損傷修復,癌代謝に関わるFIRに着目した消化器・難治がんの診断法および包括的がん治療法の開発. 金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的研究拠点. 2018. 2017. 163

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Works (5)：

Professional career (1)：

Association Membership(s) (3)：

CBI学会 , 日本エイズ学会 , 日本薬学会

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