Tokuyama Hidetoshi

トクヤマヒデトシ | Tokuyama Hidetoshi

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://www.pharm.tohoku.ac.jp/~seizou/index.html , http://www.pharm.tohoku.ac.jp/~seizou/index-e.html

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (31)：

2024 - 2029 Late-Stage Functionalization戦略に立脚した複雑天然物の自在な網羅的合成
2024 - 2026 アラインおよびラジカル種の高度な制御による高次構造天然非天然物ライブラリーの構築
2021 - 2024 新規高難度酸化反応の開発を基盤とする高次構造天然物の合成研究
2020 - 2022 Development of innovative one-pot multi-step continuous cross-coupling reaction by dynamic control of catalyst structure
2018 - 2021 革新的連続反応プロセスの開発を基盤とする高次構造天然物の合成研究

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Papers (207)：

Samuele Sala, Masashi Shimomura, Louisa Tham, Juri Sakata, Alexandre N. Sobolev, Stephen A. Moggach, Jane Fromont, Oliver Gomez, Matthew J. Piggott, Hidetoshi Tokuyama, et al. Semisynthetic Studies Establish a Role for Conjugate Halide Exchange in the Formation of Chlorinated Pyrroloiminoquinones and Related Alkaloids. Journal of Natural Products. 2024
Juri Sakata, Toshifumi Tatsumi, Akira Sugiyama, Akihiro Shimizu, Yuya Inagaki, Hiroto Katoh, Takefumi Yamashita, Kazuki Takahashi, Sho Aki, Yudai Kaneko, et al. Antibody-mimetic drug conjugate with efficient internalization activity using anti-HER2 VHH and duocarmycin. Protein Expression and Purification. 2023. 106375-106375
Masashi Shimomura, Kohta Ide, Juri Sakata, Hidetoshi Tokuyama. Unified Divergent Total Synthesis of Discorhabdin B, H, K, and Aleutianamine via the Late-Stage Oxidative N,S-Acetal Formation. Journal of the American Chemical Society. 2023. 145. 33. 18233-18239
Kosuke Okada, Ken-ichi Ojima, Hirofumi Ueda, Hidetoshi Tokuyama. Concise Total Synthesis of (+)-Pleiocarpamine and Convergent Total Syntheses of (+)-Voacalgine A and (+)-Bipleiophylline via an Aerobic Oxidative Coupling. Journal of the American Chemical Society. 2023. 145. 30. 16337-16343
Ken-ichi Ojima, Hirofumi Ueda, Hidetoshi Tokuyama. Synthetic Studies on Cimiciduphytine. Bulletin of the Chemical Society of Japan. 2023. 96. 5. 484-495

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MISC (89)：

Ueda, Hirofumi, Tokuyama, Hidetoshi. Dimerization of Peptides by Tryptophan Selective Oxidation. Biochemistry & Industry. 2023. 81. 6. 522-523
徳山英利. インドールアルカロイドハプロファイチンの全合成ーThe last synthesis を目指して. ドラマチック有機合成化学感動の瞬間、有機合成化学協会編. 2023. 28-29
坂田樹里, 巽俊文, 山次健三, 児玉龍彦, 金井求, 徳山英利, 杉山暁. Antibody Mimetic Drug Conjugateによるがん治療法開発. 日本抗体学会学術大会プログラム・抄録集(Web). 2023. 2nd
Hidetoshi Tokuyama. Synthetic Organic Chemistry in the Era of New Modality. Journal of Synthetic Organic Chemistry, Japan. 2022. 80. 4. 321-321
Hidetoshi Tokuyama. Construction of N-Heterocycles Fused with a Highly Substituted Benzene Ring by a Benzyne-Mediated Cyclization/Functionalization Cascade Reaction and Its Application to the Total Synthesis of Marine Natural Products. Chemical and Pharmaceutical Bulletin. 2021. 69. 8. 707-716

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Patents (8)：

光学活性FR900482の合成中間体および該中間体の簡便な合成工程を含む光学活性FR900482の合成方法
ビンブラスチン合成用中間体類、それらの製法、およびビンブラスチン類の合成方法
ユーディストミン合成中間体およびその合成方法
オキサチアゼピン環の合成方法
ビンドリン合成中間体およびビンドリン合成中間体の合成方法

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Books (19)：

Modern Natural Product Synthesis, Overcoming Difficulties
Springer Singapore 2024 ISBN:9789819716180
ドラマチック有機合成化学感動の瞬間100
化学同人 2023 ISBN:9784759823363
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules
Springer 2019 ISBN:9789811362439
CSJ Current Review 27 天然有機化合物の全合成独創的なものづくりの反応と戦略
化学同人 2018 ISBN:9784759813876
アルカロイドの科学
化学同人 2017 ISBN:9784759814187

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Lectures and oral presentations (130)：

Bioinspired total synthesis of structurally complex alkaloids
(RSC Natural Product Reports 40th Anniversary symposium, Saarbrucken, Germany 2024)
Total Synthesis of Bisindole Alkaloids via Late-Stage Oxidative Coupling Strategy
(1st Maruoka Conference on the Frontier of Organic Synthesis and Catalysis 2024)
Total Synthesis of Bisindole Alkaloids via Late-Stage Oxidative Coupling Strategy
(2024 International Forum of Reactions and Processes for Pharmaceutical Development, Chengdu, China 2024)
合成終盤での酸化反応を駆使した複雑なアルカロイドの全合成
(早稲田大学大学院先進理工学研究科講演会 2024)
Celebrating 50 Years of Excellence at Penn
(A Symposium in Honor of Professor Amos B. Smith, III, Philadelphia, USA 2024)

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Education (3)：

1992 - 1994 Tokyo Institute of Technology Graduate School, Division of Science and Engineering
1990 - 1992 Tokyo Institute of Technology Graduate School, Division of Science and Engineering
1986 - 1990 Tokyo Institute of Technology Faculty of Science Department of Chemistry

Professional career (1)：

博士(理学) (Tokyo Institute of Technology)

Work history (10)：

2024/04 - 現在東北大学大学院薬学研究科副研究科長
2019/04 - 現在東北大学大学院薬学研究科分子薬科学専攻専攻長
2006/05 - 現在 Tohoku University Graduate School of Pharmaceutical Sciences Professor
2003/02 - 2006/04 The University of Tokyo Graduate School of Pharmaceutical Sciences Associate Professor
2002/10 - 2006/03 JST さきがけ研究21「合成と制御」領域研究者兼任

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Committee career (19)：

2023/10 - 現在日本学術会議 26-27期連携会員
2023/08 - 現在 Organic Syntheses Board of Editors Member
2023/05 - 現在 Natural Product Reports, Royal Society of Chemistry Editorial Board Member
2023/03 - 現在日本薬学会創薬セミナーアドバイザー
2020/01 - 現在 International Society of Heterocyclic Chemistry Advisory Committee Member

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Awards (17)：

2023/12 - International Conference of Cutting-Edge Organic Chemistry in Asia Asian Core Program Lectureship Award (Thailand)
2023/06 - The Royal Society of Chemistry Fellow of the Royal Society of Chemistry (FRSC)
2018/11 - International Congress on Pure & Applied Chemistry Langkawi, Symposium Award
2017/11 - International Conference of Cutting-Edge Organic Chemistry in Asia Lectureship Award (China)
2015/08 - International Society of Heterocyclic Chemistry International Society of Heterocyclic Chemistry, Alan R. Katritzky Junior Award in Heterocyclic Chemistry

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Association Membership(s) (6)：

The Society of Synthetic Organic Chemistry, Japan , The Chemical Society of Japan , The Pharmacuetical Society of Japan , Royal Society of Chemistry , American Chemical Society , International Society of Heterocyclic Chemistry

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