Rchr

J-GLOBAL ID：200901092432533433 Update date: Sep. 18, 2024

Kudo Yasusei

クドウヤスセイ | Kudo Yasusei

Affiliation and department：
Homepage URL (1)： https://yasusei6.wixsite.com/yasuseikudo

Research field (2)： Surgical dentistry , Oral medicine (pathology)

Research theme for competitive and other funds (47)：

2023 - 2026 歯周病が惹起する全身炎症性疾患の機序解明と酸化ストレス制御による予防法確立
2022 - 2026 Investigation of novel oral cancer-specific molecular targets based on genetic diversity
2022 - 2025 Investigation of the pathophysiology of oral cancer caused by Fusobacterium nucleatum infection
2022 - 2025 The identification of genes involved in the maintenance and regeneration of salivary gland stem / progenitor cells and application to new xerostomia treatment
2022 - 2025 口腔がんにおける免疫環境構築機構の解明

2021 - 2025 Investigation of novel molecular targets for oral cancer stem cells and establishment of novel oral cancer treatment strategy

2019 - 2024 Analysis of Pathogenesis of Autoimmunity through Communication between Organs

2020 - 2023 歯周炎惹起酸化ストレスに鉄代謝が及ぼす影響と体血管反応性改善のための臨床的戦略

2019 - 2022 Establishment of novel oral cancer stem cell model mimicking human oral cancer by reprogramming and insertion of gene mutation

2019 - 2021 Clarification of the mechanism on differentiation of pluripotent stem cells by Aurora-B and its application to regeneration therapy

2018 - 2021 Elucidation of regulatory chemical messengers in oral cancer stem cell niche and its diagnostic and therapeutic application

2018 - 2020 Molecular Mechanism of Autoimmune Germinal Center Reaction and a New Therapeutic Strategy for Autoimmunity

2017 - 2020 The development of preventives and therapeutics against systemic endothelial dysfunction induced by the periodontal inflammation and the effects of anesthetics to the induced endothelial dysfunction

2017 - 2019 Study on the generation of oral cancer stem cell and analysis of its nature

2017 - 2019 Establishment of highly metastatic mice model of oral squamous cell carcinoma

2016 - 2019 Analysis of autoimmunity caused by environmental factors~New pathogenesis of autoimmune disease~

2016 - 2019 Clarification of the mechanism of oral carcinogenesis by the defect of degradation of chromosome passenger complex protein

2016 - 2019 Elucidation of novel mechanism to lead DNA over-replication

2015 - 2017 Explore for master regulator of EMT in oral cancer

2013 - 2015 The mechanism of tumorigenesis by disruption of the regulation of geminin proteolysis

2011 - 2014 Mechanism of carcinogenesis by dysregulation of cell cycle via abnormal ubiquitin-mediated proteolysis

2011 - 2012 The involvement and their molecular mechanism of microRNAs in the invasion of oral cancer

2009 - 2012 Elucidation of invasive andmetastatic mechanism in oral cancer for application to molecular based diagnosisand gene therapy

2008 - 2010 Study for degradation mechanism of a cell cycle regulator induced by Stress-activated MAP kinases

2008 - 2010 Histological and molecular biological study for standardization of pathological diagnosis of salivary gland tumors

2008 - 2010 Oncogenic role of APC/C ubiquitin ligase inhibitor, Emi1

2007 - 2008 口腔扁平上皮癌の浸潤に関わる新規因子の機能および診断への応用の可能性

2005 - 2007 Development of a novel therapeutic agent of bone using synthetic peptide of ameloblastin

2005 - 2006 口腔癌におけるSkp2およびCks1タンパクの過剰発現のメカニズムの解明

2005 - 2006 PC-1を標的としたセメント質形成機構の解明と歯周再生療法開発に関する萌芽研究

2004 - 2005 Periodontal destruction and innate immunity via toll-like receptors

2003 - 2005 Study on alteration of expression of genes and proteins related to development, progression and characteristic morphogenesis of salivary gland tumors

2003 - 2004 SKP2siRNAを用いたp27タンパク分解抑制による制癌効果

2003 - 2004 多形性腺腫細胞株の樹立と同細胞株を用いた上皮間葉形質転換に関する検討

2002 - 2004 Identification creation of bioactive sites of enamel proteins for developing a new therapy of periodontal tissue regeneration.

2000 - 2001 口腔扁平上皮癌細胞における癌抑制遺伝子P27^<kip1>遺伝子導入による制癌効果

2000 - 2001 Experimental pathological study on roles of chemokines in LPS-induced periodontal tissue destruction - Basic analysis on remedical effects of specific antibody against chemokine -

1999 - 2001 Establishment of cementblast cell lines and periodontal ligament cell lines

1998 - 2000 Development of dental implant with support of periodontal ligament

1998 - 1999 Experimental pathological study on roles of LPS-binding receptor CD14 in LPS-induced periodontal tissue destruction

1998 - 1999 Analysis of Cell Cycle Regulators and Extracellular Matrices Associated with Cell Proliferation in Salivary Gland Tumors

1999 - 口腔扁平上皮癌における細胞周期調節因子の異常に関する研究

1999 - Study on the abnormality of cell cycle regulator in oral squamous cell carcinoma

ユビキチンリガーゼSCF複合体によるタンパク分解機構の解明

口腔扁平上皮癌の浸潤・転移に関わる新規因子の同定

The mechanism of proteolysis mediated by ubiquitin ligase SCF complex

Exploring novel factor for invasion and metastasis of oral squamous cell carcinoma

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Papers (144)：

Kumiko Kamada, Naito Kurio, Yasuhiro Mouri, Yasusei Kudo. Combination treatment with hyaluronic acid synthesis and Bcl-2 inhibitors induces senolytic elimination of oral squamous cell carcinoma cells in vitro. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology. 2024
Shengjian Jin, Takaaki Tsunematsu, Taigo Horiguchi, Yasuhiro Mouri, Wenhua Shao, Keiko Miyoshi, Hiroko Hagita, Motoharu Sarubo, Natsumi Fujiwara, Guangying Qi, et al. Involvement of the OTUB1-YAP1 axis in driving malignant behaviors of head and neck squamous cell carcinoma. Cancer medicine. 2023
金晟劍, 常松貴明, 堀口大吾, 毛利安宏, 邵文華, 三好圭子, 水澤典子, 萩田浩子, 猿棒元陽, 吉田佳世, et al. 頭頸部扁平上皮癌(HNSCC)の進行における脱ユビキチン化酵素OTUB1の役割(The role of deubiquitinating enzyme, OTUB1 in head and neck squamous cell carcinoma(HNSCC) progression). 日本癌学会総会記事. 2023. 82回. 1084-1084
Wenhua Shao, Mayuko Ichimura-Shimizu, Hirohisa Ogawa, Shengjian Jin, Mitsuko Sutoh, Satoko Nakamura, Miki Onodera, Hirosuke Tawara, Shunji Toyohara, Ryoji Hokao, et al. Establishment of repeated liver biopsy technique in experimental mice. Heliyon. 2023. 9. 6. e16978
Anrizandy Narwidina, Aya Miyazaki, Kokoro Iwata, Rika Kurogoushi, Asuna Sugimoto, Yasusei Kudo, Keita Kawarabayashi, Yoshihito Yamakawa, Yuki Akazawa, Takamasa Kitamura, et al. Iroquois homeobox 3 regulates odontoblast proliferation and differentiation mediated by Wnt5a expression. Biochemical and biophysical research communications. 2023. 650. 47-54

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MISC (220)：

牛尾綾, 新垣理恵子, 工藤保誠, 石丸直澄. 次世代歯学研究者のゆくえ自己免疫疾患モデルにおける標的臓器常在型マクロファージの役割. Journal of Oral Biosciences Supplement. 2019. 2019. 61-61
牛尾綾, 大塚邦紘, 新垣理恵子, 工藤保誠, 石丸直澄. CCL22 and autoimmune diseases. 臨床免疫・アレルギー科 = Clinical immunology & allergology. 2019. 71. 5. 520-526
牛尾綾, 新垣理恵子, 大塚邦紘, 工藤保誠, 石丸直澄. シェーグレン症候群病態形成におけるCCL22産生マクロファージの役割. 日本病理学会会誌. 2019. 108. 1. 317-317
大塚邦紘, 山田安希子, 齋藤雅子, 牛尾綾, 常松貴明, 木曽田暁, 工藤保誠, 新垣理恵子, 石丸直澄. Ascl2を介した濾胞ヘルパーT細胞分化異常による自己免疫疾患の病態形成を促進する. 日本病理学会会誌. 2019. 108. 1. 317-317
新垣理恵子, 牛尾綾, 大塚邦紘, 工藤保誠, 石丸直澄. 多層化カーボンナノチューブ吸入暴露初期の肺胞マクロファージの動態. 日本病理学会会誌. 2019. 108. 1. 353-353

ｍore...

Education (2)：

1996 - 1999 Hiroshima University Graduate School, Division of Dental Research
1990 - 1996 Hiroshima University Faculty of Dentistry

Professional career (1)：

博士(歯学) (広島大学)

Work history (8)：

2020/07 - 現在 Tokushima University Graduate School of Biomedicak Sciences Department of Oral Bioscience Professor
2012/04 - 2020/06 Tokushima University Graduate School of Biomedical Sciences Department of Oral Molecular Pathology
2002/04 - 2013/10 広島大学大学院医歯薬学総合研究科助教
2003/11 - 2012/03 Hiroshima University
2011/01 - 2011/03 ニューヨーク大学医学部・がん研究所客員研究員

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Awards (9)：

2016/01 - 徳島大学平成27年度康楽賞
2014/05 - 7th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases Best poster presentation Award
2014/03 - 徳島大学歯学部ベストメンター賞
2008/11 - 日本病理学会学術研究賞
2007/03 - 日本病理学会学術奨励賞

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