Morita Takao

モリタタカオ | Morita Takao

Affiliation and department：
Job title： Professor

Research field (1)： Oral medicine

Research theme for competitive and other funds (28)：

2023 - 2026 プロテオミクスによるタンパク質選定と歯の発生段階における発現機能の新解析
2021 - 2025 New diagnostic method of oral dryness by ELISA method produced by using salivary biomarker as an antigen
2021 - 2024 Development of novel method for xerostomia by autologous serum with freeze-drying technique
2021 - 2024 唾液腺感受性亢進におけるβアレスチンシグナル経路の関与とその分子機構の解明
2020 - 2023 歯の発生過程における上皮間葉相互作用のプロテオミクスによる解明

2020 - 2023 In vivo機能解析による唾液腺の代償性機能亢進機構の解明と分泌亢進誘導

2020 - 2022 Development of an extracellular messenger imaging method using silica nonwoven fabric and competitive FRET

2018 - 2021 A new method for diagnosis of oral dryness using salivary biomarker

2017 - 2020 Elucidation of mechanism and molecular basis of compensatory hypertrophy in salivary gland using the intravital imaging and comprehensive gene analysis

2016 - 2019 Development of low invasive long-term imaging technique for studying salivary gland Ca2+ response and functional regeneration

2014 - 2017 Analysis of Ca2+ response and mechanism of salivary secretion in salivary gland cells using in vivo micro imaging

2014 - 2017 唾液腺における開口分泌とCa2+、cAMP及びSNARE動態のリアルタイム解析

2014 - 2016 Development of bioimaging methods for intra- and intercellular messengers

2011 - 2015 Intravital imaging study for the regulation of salivary gland functions

2011 - 2013 Real-time monitoring of Ca2+ responses in rat submandibular glands and salivary secretions in living animals.

2010 - 2012 Analysis of spatiotemporal pattern in IP^ production in submandibulargland using fluorescent-biosenseor

2010 - 2012 In vivo遺伝子発現系を用いた唾液腺腺房細胞における分泌の分子機構の解明

2008 - 2010 Imaging analysis of the electrolyte transport and protein secretions in salivary ducts to reveal their regulatory mechanisms

2007 - 2008 In vivoの唾液腺に発現させたシグナル分子の動態及び機能のリアルタイム解析

2004 - 2007 STUDIES ON THE DYNAMICS OF PHOSPHOINOSITIDE PATHWAYS AND THE DEVELOPMENT OF FLUORESCENT BIOSENSORS

2005 - 2006 Visualization of spatio-temporal pattern of IP3/Ca2+ signaling in salivary glands

2003 - 2005 ビジュアルスクリーニング法を用いた耳下腺細胞の新規シグナル分子の検索と機能解析

2003 - 2004 Real-time monitoring of cellular signaling in salivary secretion by multiphoton excitation imaging

2002 - 2003 Physiological roles of the calcium wave for the regulation of fluid and electrolytes secretion in salivary cells

2001 - 2002 GFP融合タンパク質によるIP3受容体の可視化とその分布変化の解析

2001 - 2002 蛍光共鳴エネルギー転移を応用したイノシトール三リン酸の細胞内動態のイメージング

2000 - 2002 Imaging of the signal molecules mediating secretory responses in salivary gland cells

Study of molecular mechanisms on salivary secretion

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Papers (65)：

Mari Shimatani, Takao Morita, Rezon Yanuar, Akihiro Nezu, Akihiko Tanimura. Local anesthetics inhibit muscarinic acetylcholine receptor-mediated calcium responses and the recruitment of β-arrestin in HSY human parotid cells. Journal of oral biosciences. 2024. 66. 2. 465-472
Narumi Ishida, Kaori Murata, Takao Morita, Shingo Semba, Akihiro Nezu, Akihiko Tanimura. Spontaneous calcium responses of sf2 rat dental epithelial cells stably ex-pressing the calcium sensor g-geco. Biomedical Research (Japan). 2021. 42. 5. 193-201
Nezu A, Morita T, Nagai T, Tanimura A. Simultaneous monitoring of Ca2+ responses and salivary secretion in live animals reveals a threshold intracellular Ca2+ concentration for salivation. Exp Physiol. 2019. 104. 61-69
Takahashi A, Morita T, Murata K, Minowa E, Jahan A, Saito M, Tanimura A. Effects of full-length human amelogenin on the differentiation of dental epithelial cells and osteoblastic cells. Arch Oral Biol. 2019. 107
Tanimura A, Nezu A, Morita T, Murata K. Advances in methods for analyzing IP₃ signaling and understanding of coupled Ca²⁺ and IP₃ oscillations]. Folia pharmacologica Japonica. 2018. 152. 1. 21-27

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MISC (54)：

Azmeree Jahan, 村田佳織, 森田貴雄, 根津顕弘, 谷村明彦. 蛍光タンパク質の円縦列変異体を利用した改良型IP3センサーの開発(Development of improved IP3 biosensors using circularly permuted fluorescent proteins). Journal of Oral Biosciences Supplement. 2018. 2018. 328-328
村田佳織, 森田貴雄, 根津顕弘, 齊藤正人, 谷村明彦. 歯原生上皮細胞のマイグレーションと遺伝子発現におけるカルシウム応答の役割. Journal of Oral Biosciences Supplement. 2018. 2018. 335-335
根津顕弘, 森田貴雄, 谷村明彦. 細胞質型イノシトール三リン酸(IP3)バイオセンサー"cLIBRAvIIS"を用いた唾液腺腺房細胞のIP3測定法の開発. 北海道医療大学歯学雑誌 = The dental journal of Health Sciences University of Hokkaido. 2016. 35. 2. 109-118
高橋亜友美, 森田貴雄, 村田佳織, 齊藤正人, 谷村明彦. ラットエナメル芽細胞とマウス骨芽細胞の分化誘導に対するリコンビナント・ヒトアメロジェニンの作用. Journal of Oral Biosciences Supplement. 2016. 2016. 406-406
村田佳織, 福本敏, 森田貴雄, 高橋亜友美, 齊藤正人, 谷村明彦. ラット歯原性上皮細胞の分化とマイグレーションにおけるカルシウム応答の解析. Journal of Oral Biosciences Supplement. 2016. 2016. 408-408

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Education (4)：

- 1997 The University of Tokyo
- 1997 The University of Tokyo Graduate School, Division of Medical Sciences
- 1990 Niigata University Faculty of Science Department of Biology
- 1990 Niigata University Faculty of Science

Professional career (2)：

(BLANK) (The University of Tokyo)
(BLANK) (Niigata University)

Work history (2)：

1998 - 2000 Niigata University Brain Research Institute
1997 - 1998 科学技術振興事業団研究員

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