Rchr
J-GLOBAL ID：200901093304204199
Update date: Nov. 11, 2024
MIYAKI SHIGERU
ミヤキ シゲル | MIYAKI SHIGERU
Affiliation and department：
Job title：
Professor (special recognition)
Research field (1)：
Orthopedics
Research keywords (1)：
Musculoskeletal Biology, Osteoarthritis, miRNAs, Exosomes, Regenerative Medicine, Tendon, Ligament
Research theme for competitive and other funds (42)：
- 2022 - 2025 変形性関節症における骨棘軟骨を用いた新規軟骨再生医療の確立
- 2022 - 2025 低酸素下でのみ薬剤を遊離作用可能にしたプロドラッグを用いた骨肉腫治療の開発
- 2022 - 2025 レチノイン酸による骨の形成・維持の制御メカニズムの解明と臨床応用への発展
- 2022 - 2024 関節軟骨維持・再生に関わる骨格幹細胞の同定
- 2021 - 2024 microRNAを介した腰椎椎体終板障害の機能解明および新たな治療戦略の確立
- 2021 - 2024 切断四肢保存のための人工赤血球灌流療法の開発
- 2020 - 2023 Search and design of compounds with synergistic effects by AI
- 2020 - 2023 腱・靭帯の分子生物学的情報を基盤とした新たな治療法の開発
- 2020 - 2023 運動器における幹細胞老化の理解と制御
- 2020 - 2023 Study on the mechanisms of anti-aging food compounds by suppressing amyloid formation in gut
- 2020 - 2023 Development a novel approach for articular cartilage repair/regeneration using microneedle array sheet
- 2019 - 2022 The role of chondrocyte/senescent cells-derived exosomal microRNA in pathogenesis of osteoarthritis, and in silico drug discoveryathogenesis of osteoarthritis and in silico drug discovery
- 2019 - 2022 Development of a novel delivery system and osteosarcoma therapy using down-regulated MSC-derived exosomes
- 2019 - 2022 New strategy for the diagnosis of osteonecrosis of the femoral head
- 2018 - 2021 Systems Bone Biology
- 2018 - 2021 Therapeutic strategy for osteoarthritis by targeting neuropeptides.
- 2017 - 2020 Development of articular cartilage repair using minced cartilage and microRNA/exosomes
- 2017 - 2020 Anti-aging effect of transthyretin stabilizing food-derived bioactive compounds
- 2017 - 2020 Elucidation and control of gliosis mechanism after spinal cord injury via endoplasmic reticulum stress sensor OASIS
- 2016 - 2018 The role of microRNA in maturation of tendon /ligament
- 2016 - 2018 Search for early marker of Osteoarthritis using Exosome and establish monitoring index of exercise and nutritional effects
- 2015 - 2018 Analysis of novel communication factor exosomes for the treatment and diagnosis of osteoarthritis
- 2015 - 2018 Acceleration of bone repair using miRNA-induced bone marrow cells for osteonecrosis
- 2014 - 2017 Preventive effect of food-derived bioactive compounds with anti-angiogenic and autophagy activities on aging.
- 2014 - 2017 Development of a novel diagnostic system for osteochondritis dissecans of the knee using optical coherence tomography
- 2016 - 2017 Analysis of novel communication factor exosomes for the treatment and diagnosis of osteoarthritis(Fostering Joint International Research)
- 2014 - 2016 The strategy for refractory fracture using the combination of microRNA with magnetic targeting system
- 2013 - 2016 The role of exosomes as a novel communication factor in tissue regeneration
- 2013 - 2016 Development of new treatments using pro-angiogenic and tissue-specific microRNAs for the injury of musculoskeletal and nerve tissue
- 2013 - 2015 Bach1 deficiency reduces severity of osteoarthritis, and induction of HO-1 is a novel target in OA prevention.
- 2012 - 2015 Therapeutic strategy based on angiogenesis induce by microRNA in orthopaedic field
- 2012 - 2015 Exosome-formed miRNA for the treatment of osteosarcoma
- 2012 - 2015 Exosomes including microRNA as a new mediators of communication among joint cells in OA pathogenesis
- 2012 - 2014 cartilage regeneration using decellularized tissue, peripheral blood mononuclear cell, and microRNA
- 2010 - 2013 四肢前後軸を形成する転写ネットワークの解析
- 2010 - 2011 Elucidation for mechanisms of development and regeneration in tendon and ligament
- 2008 - 2010 Non-coding RNAs regulating cartilage development
- 2007 - 2009 腱の発生・再生に関わるホメオボックス遺伝子Mohawkの機能解析
- 2006 - 2007 核内蛋白質のクロマティン因子および成長因子としての内軟骨性骨化における役割の解明
- 2005 - 2007 新規Znフィンガープロテインの機能解析による軟骨発生・分化のメカニズムの解明
- 2005 - 2006 ヒト骨髄由来間葉系幹細胞におけるmicroRNAによる分化制御の網羅的解析
- 2005 - 2005 核内蛋白HMGB1の成長因子としての骨分化におけるメカニズムの解明
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Papers (78)：
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Kawasaki, Riku, Oshige, Ayano, Kono, Nanami, Yamana, Keita, Hirano, Hidetoshi, Miura, Yamato, Yorioka, Ryuji, Bando, Kaori, Tabata, Anri, Yasukawa, Naoki, et al. Extracellular Vesicles Comprising Carborane Prepared by a Host Exchanging Reaction as a Boron Carrier for Boron Neutron Capture Therapy. ACS APPLIED MATERIALS & INTERFACES. 2024. 16. 36. 47137-47149
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Inoue, Tadashi, Kano, Toshiya, Nakasa, Tomoyuki, Ishikawa, Masakazu, Inoue, Keiichiro, Kawabata, Shingo, Miyaki, Shigeru, Kamei, Naosuke, Adachi, Nobuo. Development of a novel approach for restoration of the meniscus using silk-elastin in a rabbit meniscus injury model. BMC MUSCULOSKELETAL DISORDERS. 2024. 25. 1
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Nakata, Kyohei, Ishikawa, Masakazu, Kamei, Naosuke, Miyaki, Shigeru, Adachi, Nobuo, Inoue, Keiichiro, Kawabata, Shingo. Skeletal muscle injury treatment using the Silk Elastinツョ injection in a rat model. REGENERATIVE THERAPY. 2024. 26. 180-187
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Kawabata, Shingo, Nakasa, Tomoyuki, Nekomoto, Akinori, Yimiti, Dilimulati, Miyaki, Shigeru, Adachi, Nobuo. Osteophyte Cartilage as a Potential Source for Minced Cartilage Implantation: A Novel Approach for Articular Cartilage Repair in Osteoarthritis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024. 25. 10
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Ishibashi, Shigeki, Kamei, Naosuke, Tsuchikawa, Yuji, Nakamae, Toshio, Akimoto, Takayuki, Miyaki, Shigeru, Adachi, Nobuo. Myelin-Specific microRNA-23a/b Cluster Deletion Inhibits Myelination in the Central Nervous System during Postnatal Growth and Aging. GENES. 2024. 15. 4
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MISC (15)：
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山家 新勢, 吉本 由紀, 樋口 真之輔, 味八木 茂, 宿南 知佐. TumdCreノックインマウスの作製とTnmd陽性細胞の系譜解析. 日本骨代謝学会学術集会プログラム抄録集. 2021. 39回. 143-143
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柳樂 慶太, 味八木 茂, 生田 祥也, 眞田 洋平, 篠原 正浩, 安達 伸生, 永島 英樹, Lotz Martin. 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立. 日本整形外科学会雑誌. 2019. 93. 8. S1949-S1949
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柳樂 慶太, 真田 洋平, 篠原 正浩, 萩野 浩, 味八木 茂. 変形性膝関節症マウスモデルを用いた軟骨下骨の組織学的スコアリングシステムの確立. 日本骨代謝学会学術集会プログラム抄録集. 2019. 37回. 229-229
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秋本 崇之, 狩野 豊, 中村 一隆, 味八木 茂, 浅原 弘嗣, 牛田 多加志. ホメオボックス遺伝子Mkx欠損マウスの骨格筋表現型. 体力科学. 2015. 64. 6. 560-560
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Soutarou Izumi, Tomoyuki Nakasa, Shigeru Miyaki, Mitsuo Ochi. Stf-083010, the Inhibitor of ER Stress Transducer IRE1, Suppresses Rheumatoid Synovitis. ARTHRITIS & RHEUMATOLOGY. 2015. 67
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Patents (1)：
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変形性関節症予防用組成物、変形性関節症予防用食品組成物、変形性関節症予防用食品添加物及び変形性関節症予防用医薬
Professional career (1)：
- Ph.D. (University of Tsukuba)
Work history (5)：
- 2023/06 - 現在 Hiroshima University Professor (Special recognition)
- 2011/03 - 2023/06 Hiroshima University Hospital Associate professor
- 2009/06 - 2011/03 The Scripps Research Institute Sr. Research Accosiate
- 2007/07 - 2009/05 The Scripps Research Institute Research Associate
- 2004/03/01 - 2007/06/30 National Center for Child Health and Development Research Associate
Awards (4)：
- 2010 - Arthritis National Research Foundation, Grant Award
- 2010 - World Congress on Osteoarthritis (OARSI), Young Investigator Award
- 2010 - Orthopaedic Research Society (USA), The New Investigator Recognition Award
- 2009 - Arthritis National Research Foundation (USA), Grant Award
Association Membership(s) (6)：
老化促進モデルマウス(SAM)学会
, The Japanese Society for Bone and Mineral Research
, The Japanese society for regenerative medicine
, The Japanese Society of Cartilage Metabolism
, Orthopaedic Research Society
, Osteoarthritis research society international
