Rchr
J-GLOBAL ID：200901094097758088   Update date: Oct. 10, 2024

Nakao Ryoma

ナカオ リョウマ | Nakao Ryoma
Affiliation and department：
National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I

About National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I


Job title： Head of Laboratory
Research field  (4)： Infectious disease ,  Conservative dentistry and endodontics ,  Oral medicine (pathology) ,  Bacteriology
Research keywords  (8)： Bacterial membrane vesicles ,  biofilms ,  Porphyromonas gingivalis ,  Periodontal diseases ,  Anti-bacterial agents ,  Lipopolysaccharide ,  Vaccine ,  Infectious Diseases in Oral Cavity
Research theme for competitive and other funds  (39)：
  • 2024 - 2027 Search for natural compounds with anti-periodontal pathogens and anti-glycation activity to prevent and ameliorate periodontal disease-related systemic diseases.
  • 2022 - 2025 Creation of a vaccine platform with innate immune activation
  • 2022 - 2025 Analysis of immune responses induced by intranasal administration of B. pertussis vaccine candidates
  • 2021 - 2025 Dynamic behavior and pathological significance of small RNA in outer membrane vesicles of periodontopathic bacteria
  • 2020 - 2024 歯周病関連疾患を予防・改善する抗糖化及び抗歯周病原菌活性プレニル誘導体の探索研究
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Papers (50)：
  • Kimihiro Abe, Hiroko Yahara, Ryoma Nakao, Takehiro Yamaguchi, Yukihiro Akeda. A simple and cost-effective transformation system for Porphyromonas gingivalis via natural competence. Frontiers in Microbiology. 2024. in press
  • Ryoma Nakao, Ayami Takatsuka, Kengo Mandokoro, Naoki Narisawa, Tsuyoshi Ikeda, Hideki Takai, Yorimasa Ogata. Multimodal inhibitory effect of matcha on Porphyromonas gingivalis. Microbiology Spectrum. 2024. 12. 7
  • Sadao Aoki, Hiroko Yahara, Ryoma Nakao, Osamu Tsuzukibashi, Koji Yahara. Development of selective isolation media for detecting the genera Actinomyces and Schaalia from oral specimens containing indigenous bacteria. Access Microbiology. 2024. 6. 5
  • Minato Takahara, Satoru Hirayama, Hiroyuki Futamata, Ryoma Nakao, Yosuke Tashiro. Biofilm-derived membrane vesicles exhibit potent immunomodulatory activity in Pseudomonas aeruginosa PAO1. Microbiology and Immunology. 2024. 68. 7. 224-236
  • Hiroki Uchiyama, Toshifumi Kudo, Takehiro Yamaguchi, Nozomu Obana, Kenji Watanabe, Kimihiro Abe, Hidetaka Miyazaki, Masanori Toyofuku, Nobuhiko Nomura, Yukihiro Akeda, et al. Mucosal adjuvanticity and mucosal booster effect of colibactin-depleted probiotic Escherichia coli membrane vesicles. Human Vaccines and Immunotherapeutics. 2024. 20. 1
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MISC (15)：
  • 泉福英信, 中尾龍馬. Effects of Salts on Complex Bacterial Biofilm Formation. ソルト・サイエンス研究財団助成研究報告集 2 医学 食品科学編. 2018. 2016. 151-159
  • Ryoma Nakao. Infectious Disease Up-to-Date: Antimicrobial Resistance in Dental Care. The Nippon Dental Review. 2015. 75. 10. 152-153
  • 永山 恭子, 尾花 望, 中尾 龍馬, 泉福 英信, 中村 幸治, 野村 暢彦. P25-14 クロストリジウム属細菌が産生するメンブランベシクルは宿主細胞と相互作用する(ポスター発表). 日本微生物生態学会講演要旨集. 2014. 2014. 245-245
  • R. Nakao, S. Takashiba, S. Kosono, M. Yoshida, D. Bai, H. Watanabe, M. Ohnishi, H. Senpuku. Effect of Porphyromonas gingivalis outer membrane vesicles on gingipain-mediated detachment of cultured oral epithelial cells and immune responses. IMMUNOLOGY. 2013. 140. 112-113
  • D. Bai, R. Nakao, H. Uematsu, H. Senpuku. Immunoreactive antigens recognized by sera of mice intranasally immunized with outer membrane vesicles of Porphyromonas gingivalis. IMMUNOLOGY. 2013. 140. 119-120
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Patents (11)：
  • バチルス属細菌の膜小胞を基盤とする担体及びそれを用いた製品
  • プロバイオティクス大腸菌の二重変異株、該二重変異株から産生される膜小胞、及びそれを用いた製品
  • Novel Methodology to Enhance Membrane Vesicle Production
  • ポルフィロモナス・ジンジバリス用殺菌剤、及びポルフィロモナス・ジンジバリスに対する抗菌作用を有する成分を製造する方法
  • Outer Membrane Vesicles Carrying Exogenous Protein Antigen
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Books (5)：
  • Methods in Molecular Biology
    Springer Nature 2021
  • Methods in Molecular Biology: Periodontal Pathogens, Methods and Protocol
    Springer Nature 2020
  • デンタルスタッフの口腔衛生学
    医歯薬出版 2018
  • 食と微生物の事典
    朝倉書店 2017 ISBN:9784254431216
  • Bacterial Polysaccharides Current Innovations and Future Trends
    Caister Academic Press 2009 ISBN:9781904455455
Lectures and oral presentations  (84)：
  • Effect of oral moisturizing gel with chlorhexidine, propolis, curry leaf, or turmeric in patients following head and neck radiotherapy
    (The 61st Annual meeting of Japanese Association for Oral Biology 2019)
  • Mechanistic insights into inhibitory activity of Matcha green tea on Porphyromonas gingivalis
    (The 61st Annual Meeting of Japanese Association for Oral Biology 2019)
  • Effects of regulatory genes to virulence factors on GTF-dependent Membrane vesicles in Streptococcus mutans
    (The 61st Annual Meeting of Japanese Association for Oral Biology 2019)
  • Spatiotemporal analysis of bacterial surfaces treated with antimicrobials
    (The 61st Annual Meeting of Japanese Association for Oral Biology 2019)
  • The probiotic Escherichia coli Nissle 1917-derived membrane vesicles carrying pneumococcal capsule elicit mucosal immune responses
    (The 13th Vaccine congress 2019)
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Education (4)：
  • 1999 - 2003 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences PhD Student, Maxillofacial Surgery
  • 1998 - 1999 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Maxillofacial Surgery
  • 1992 - 1998 Hokkaido University Faculty of Dental Medicine
  • 1989 - 1992 Johoku Senior High School
Professional career (2)：
  • Ph.D. (Tokyo Medical and Dental University)
  • D.D.S. (Hokkaido University)
Work history (5)：
  • 2024/07 - 現在 National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I Head
  • 2010/05 - 2024/06 National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I Senior Research Scientist
  • 2008/05 - 2010/04 Umeå University Department of Molecular Biology, Faculty of Medicine Swedish Research Council, Visiting Research Fellow
  • 2008/04 - 2008/05 National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I Senior Research Scientist
  • 2003/04 - 2008/03 National Institute of Infectious Diseases Laboratory of Oral Bacterial Infection, Department of Bacteriology I Research Fellow
Awards (1)：
  • 2012/10 - The Naito Foundation Excellent Poster Award Role of Outer Membrane Vesicles of Porphyromonas gingival in the context of Immunopathology
Association Membership(s) (7)：
THE JAPANESE SOCIETY FOR VACCINOLOGY ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  International Association for Dental Research ,  JAPANESE ASSOCIATION FOR ORAL BIOLOGY ,  American Society for Microbiology ,  JAPANESE SOCIETY FOR BACTERIOLOGY ,  Japanese Biochemical Society (JBS)
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