Maki Masatoshi

Homepage URL (1)： http://www.agr.nagoya-u.ac.jp/~mcr/

Research field (1)： Applied biochemistry

Research keywords (7)： calpain , ALG-2/PDCD6 , ESCRT , apoptosis , molecular recognition , protein-proein interaction , calcium

Research theme for competitive and other funds (26)：

2020 - 2023 Elucidation of physiological functions of EF-hand protein ALG-2 in lysosomal membrane damage response
2017 - 2020 Elucidation of physiological functions of the EF-hand protein ALG-2 as a calcium-stress response factor
2015 - 2018 Elucidation and application of regulatory mechanisms underlying biogenesis of transport vesicles budding from the endoplasmic reticulum
2015 - 2017 Analysis of cellular signal transduction by amino acids via intracellular Ca2+ rise
2014 - 2017 Mechanism of calcium-response regulation of EF-hand protein ALG-2 in the nucleus and membranes

2013 - 2015 Regulatory mechanism of adipocyte differentiation by PLSCR3 mediated by extracellularly secreted vesicle exosomes

2012 - 2015 Analysis of oscillatory calcium signaling and its decoding machinery in the early secretory pathway

2011 - 2014 Roles of calcium-dependent adaptor protein ALG-2 in regulation of intracellular delivery system

2009 - 2010 BSCRT関連因子との相互作用によるカルパイン7/PalBH の生理機能

2009 - 2010 Studies on regulation of transport vesicle budding from endoplasmic reticulum by the calcium-binding protein ALG-2

2008 - 2010 Analysis of calcium-dependent adaptor function of apoptosis-associated protein ALG-2

2007 - 2008 小胞輸送を介したシグナル伝達制御におけるカルパイン7/PalBHの役割

2005 - 2007 The mechanism of the Action of the calcium-binding protein ALG-2on the regulation of cell membrane receptor sorting

2005 - 2006 細胞間コミュニケーション媒体としての細胞外小胞エキソソームの形成と分泌の分子基盤

2002 - 2004 Mechanism of regulation of programmed cell death by intracellular calcium-binding protein ALG-2

2000 - 2001 Studies on activating mechanisms oftransglutaminase in epidermis

1999 - 2001 Functional analysis of a novel intracellular calcium-binding protein peflin

1996 - 1999 Mechanism of Selective Degradation of Proteins

1996 - 1997 Biochemical analysis of the novel tumor suppressor gene product RECK

1992 - 1994 エイズ制圧に向けての基礎研究柱1 HIVの分子遺伝学

1991 - 1993 Identification of endogenous calcium channel activator and develpment of clinical analysis method by spedific antibodies.

1991 - 1991 ウイルスによるがん化と抑制

1989 - 1991 Studies on Regulation of Cellular Function by Calpastatin

1988 - 1991 Analysis of gene expression of calpain and calpastatin

1988 - 1989 Intra-cellular manipulation of human retroviruses by NOS

1985 - 1987 がんにおける遺伝子発現の特異性

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Papers (173)：

Ryuta Inukai, Kanako Mori, Masatoshi Maki, Terunao Takahara, Hideki Shibata. Cytoprotective Role of Autophagy in CDIP1 Expression-Induced Apoptosis in MCF-7 Breast Cancer Cells. International journal of molecular sciences. 2024. 25. 12
Yuna Amemiya, Masatoshi Maki, Hideki Shibata, Terunao Takahara. New Insights into the Regulation of mTOR Signaling via Ca2+-Binding Proteins. International journal of molecular sciences. 2023. 24. 4
Lin Deng, Yujiao Liang, Adi Ariffianto, Chieko Matsui, Takayuki Abe, Masamichi Muramatsu, Takaji Wakita, Masatoshi Maki, Hideki Shibata, Ikuo Shoji. Hepatitis C Virus-Induced ROS/JNK Signaling Pathway Activates the E3 Ubiquitin Ligase Itch to Promote the Release of HCV Particles via Polyubiquitylation of VPS4A. Journal of virology. 2022. 96. 6. e0181121
Yuna Amemiya, Nao Nakamura, Nao Ikeda, Risa Sugiyama, Chiaki Ishii, Masatoshi Maki, Hideki Shibata, Terunao Takahara. Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin. International journal of molecular sciences. 2021. 22. 13
Ryuta Inukai, Kanako Mori, Keiko Kuwata, Chihiro Suzuki, Masatoshi Maki, Terunao Takahara, Hideki Shibata. The novel ALG-2 target protein CDIP1 promotes cell death by interacting with ESCRT-I and VAPA/B. International Journal of Molecular Sciences. 2021. 22. 3. 1-25

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MISC (40)：

尾関希美, 中山菜月, 松下明理, ZHENG Guangjie, 牧正敏, 高原照直, 柴田秀樹. Analysis of the interaction between PRRC1, a novel ER exit site localization protein, and COPII. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
森花菜子, 川野琢己, 牧正敏, 柴田秀樹, 高原照直. Role of ESCRT-III proteins IST1 and LIP5/VTA1 in the lysosomal damage response. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
天野柊吾, 林本敬大, 船戸聖音, 牧正敏, 高原照直, 柴田秀樹. Analysis of the intracellular dynamics of annexin A11 mutants associated with ALS. 日本農芸化学会大会講演要旨集(Web). 2023. 2023
雨宮優奈, 池田奈央, 牧正敏, 柴田秀樹, 高原照直. Ca²⁺/Calmodulin modulates mTORC1 activity by disrupting TSC2-Rheb interaction. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
正田駆, 石井千愛, 牧正敏, 柴田秀樹, 高原照直. Insulin receptor substrate 4 is a novel modulator of the amino acids-sensing mTORC1 pathway. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th

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