Rchr
J-GLOBAL ID:200901095122397598   Update date: Sep. 29, 2024

Ito Takaaki

イトウ タカアキ | Ito Takaaki
Affiliation and department:
Job title: Professor
Research field  (4): Developmental biology ,  Cell biology ,  Experimental pathology ,  Human pathology
Research theme for competitive and other funds  (47):
  • 2024 - 2027 Intratumor heterogeneity of small cell lung cancer
  • 2023 - 2026 小細胞肺がんでのmTOR・NOTCH1・YAP1の相互関係解析と抗がん剤耐性克服の検証
  • 2020 - 2024 小細胞肺癌でのがん免疫療法における、mTOR阻害剤併用の有用性の検証
  • 2020 - 2024 Signal molecules of ASCL1, a lineage-specific transcription factor for small cell carcinoma of the lung
  • 2018 - 2021 マウス胎仔単離肺上皮器官培養による小細胞肺癌モデルの開発
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Papers (271):
  • Takaaki Ito. Molecular pathology of small cell lung cancer: Overview from studies on neuroendocrine differentiation regulated by ASCL1 and Notch signaling. Pathology International. 2024. 74. 5. 239-251
  • Masaya Yamazaki, Shinjiro Hino, Shingo Usuki, Yoshihiro Miyazaki, Tatsuya Oda, Mitsuyoshi Nakao, Takaaki Ito, Kazuya Yamagata. YAP/BRD4-controlled ROR1 promotes tumor-initiating cells and hyperproliferation in pancreatic cancer. EMBO J. 2023. 42. 14. e112614
  • Mune Sanada, Masaya Yamazaki, Tatsuya Yamada, Kosuke Fujino, Shinji Kudoh, Yuki Tenjin, Haruki Saito, Noritaka Kudo, Younosuke Sato, Akira Matsuo, et al. Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer. Human Cell. 2022. 36. 1. 409-420
  • Mizumoto T, Yoshizawa T, Sato Y, Ito T, Tsuyama T, Satoh A, Araki S, Tsujita K, Tamura M, Oike Y, et al. SIRT7 deficiency extends lifespan in male mice with an increase of fibroblast growth factor 21. Cells. 2022. 11. 12. 3609
  • Keiichi Nakahara, Koutaro Takamatsu, Noritaka Kudo, Takaaki Ito, Mitsuharu Ueda. Histopathological Features of Gerhardt Syndrome in a Patient With Multiple System Atrophy: An Autopsy Case Report. Cureus. 2022. 14. 10. e30415
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MISC (93):
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Books (1):
  • 病理組織学的鑑別診断:肺の神経内分泌癌との比較を中心に
    金原出版・Merkel細胞・Merkel細胞癌この謎多き細胞達(小野友道、鈴木啓之編) 2005
Lectures and oral presentations  (8):
  • The molecular regulation of differentiation, proliferation and highly malignancy character of small cell lung cancer by proteomic analysis of post-translational modification
    (14th International Congress of Histochemistry and Cytochemistry 2012)
  • Significance of stat3-Hes1 system in mouse fetal lung epithelial differentiation
    (14th International Congress of Histochemistry and Cytochemistry 2012)
  • Mutant epidermal growth factor receptor reduces expression of Notch receptors and modifies lung epithelial differentiation.
    (14th International Congress of Histochemistry and Cytochemistry 2012)
  • Significance of Notch signaling in biology and pathology of lung carcinoma cell lines.
    (14th International Congress of Histochemistry and Cytochemistry 2012)
  • マウス肺におけるメチル化DNA結合蛋白質MeCP2の発現.
    (日本組織細胞化学会 2005)
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Works (7):
  • MCAF抗体を用いた新たなガン診断マーカー
    2007 - 2008
  • 癌幹細胞の病理組織切片における同定と臨床病理学的意義
    2007 - 2008
  • 牛深地域の疾患の病理学的研究
    2006 - 2008
  • 炎症性疾患におけるガレクチン9の役割と探索
    2005 - 2007
  • 肺発生過程における肺神経内分泌細胞分化と低酸素シグナルについて
    2005 - 2007
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Education (4):
  • - 1985 Yokohama City University
  • - 1985 Yokohama City University Graduate School, Division of Medicine
  • - 1980 Yokohama City University
  • - 1980 Yokohama City University Faculty of Medicine
Professional career (1):
  • Doctor of Medicine (Yokohama City University)
Work history (10):
  • 2021/04 - 現在 Kumamoto Health Science University Faculty of Health Science Dpartment of Medical Technology Professor
  • 2010 - 2021/03 Kumamoto University Faculty of Life Sciences Department of pathology and experimental Medicine Professor
  • 2003 - 2009 Kumamoto University
  • 1995 - 2003 Yokohama City University
  • 1991 - 1995 Yokohama City University
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Committee career (2):
  • 1989 - 2021/03 日本病理学会 学術評議員
  • 1992 - 日本組織細胞化学会 評議員
Awards (3):
  • 2021/04 - 日本病理学会 病理学会賞
  • 2001 - 病理学会 A演説(学術研究賞)
  • 2000 - 横浜医学会賞
Association Membership(s) (3):
日本組織細胞化学会 ,  日本病理学会 ,  肺癌学会
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