Rchr
J-GLOBAL ID：200901095134589166   Update date: Oct. 17, 2024

Shimokawa Takashi

Shimokawa Takashi | Shimokawa Takashi
Research field  (4)： Tumor biology ,  Radiology ,  Cell biology ,  Molecular biology
Research keywords  (3)： Heavy ion cancer treatment / non cancer treatment ,  radiation biology, ion beam breeding ,  Hedgehog PTCH GLI Rhabdomyosarcoma medulloblastoma, splice variant
Research theme for competitive and other funds  (10)：
  • 2023 - 2026 Development of Combination Radiation Therapy Drugs to Improve Cancer Control Rates by Regulating DNA Damage Response Molecules
  • 2020 - 2023 Development of novel cancer treatment to overcome acquired resistance mechanisms in synthetic lethal therapy targeting DNA repair
  • 2019 - 2023 重粒子線局所照射によるカンキツ類の突然変異体誘発に関する研究
  • 2019 - 2022 Development of radioprotectors that selectively protect normal tissues
  • 2019 - 2022 Quantitative evaluation of radiation-induced immunostimulating effect
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Papers (66)：
  • Reem Ahmad, Amelia Barcellini, Kilian Baumann, Malte Benje, Tamara Bender, Paloma Bragado, Alexandra Charalampopoulou, Reema Chowdhury, Anthony J Davis, Daniel K Ebner, et al. Particle Beam Radiobiology Status and Challenges: A PTCOG Radiobiology Subcommittee Report. International journal of particle therapy. 2024. 13. 100626-100626
  • Eriko Naito, Kazuyo Igawa, Sho Takada, Kenta Haga, Witsanu Yortchan, Orakarn Suebsamarn, Ryota Kobayashi, Manabu Yamazaki, Jun-Ichi Tanuma, Tsuyoshi Hamano, et al. The effects of carbon-ion beam irradiation on three-dimensional in vitro models of normal oral mucosa and oral cancer: development of a novel tool to evaluate cancer therapy. In vitro cellular & developmental biology. Animal. 2024
  • Lin Xie, Lulu Zhang, Kuan Hu, Masayuki Hanyu, Yiding Zhang, Masayuki Fujinaga, Katsuyuki Minegishi, Takayuki Ohkubo, Kotaro Nagatsu, Cuiping Jiang, et al. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell reports. Medicine. 2023. 4. 4. 100960-100960
  • Daniel K Ebner, Takashi Shimokawa, Walter Tinganelli, Charlot Vandevoorde. Editorial: New frontiers in radiobiology. Frontiers in public health. 2023. 11. 1181656-1181656
  • Mari Amino, Masatoshi Yamazaki, Koichiro Yoshioka, Noboru Kawabe, Sachie Tanaka, Takashi Shimokawa, Ryoko Niwa, Naoki Tomii, Shigeto Kabuki, Etsuo Kunieda, et al. Heavy Ion Irradiation Reduces Vulnerability to Atrial Tachyarrhythmias - Gap Junction and Sympathetic Neural Remodeling. Circulation journal : official journal of the Japanese Circulation Society. 2022
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MISC (64)：
  • 下川卓志, 富永晃好, 坂本裕一, 加川雄介. 重粒子線生物影響研究への元素分布解析の有効性検討. 量子科学技術研究開発機構資料(Web). 2024. 45
  • 網野真理, 網野真理, 株木重人, 国枝悦夫, 若月優, 森慎一郎, 下川卓志, 橋本順, 山下高史, 柳下敦彦, et al. Our Clinical Experience with “Arrhythmia Radiotherapy“: Photon and Heavy Ion Beams. 日本循環器学会学術集会(Web). 2024. 88th
  • 網野真理, 網野真理, 株木重人, 国枝悦夫, 橋本順, 山下高史, 柳下敦彦, 伊苅裕二, 下川卓志, 吉岡公一郎. 不整脈放射線治療の精度向上にむけて心臓画像検査が果たす役割. 日本生体医工学会大会プログラム・抄録集(Web). 2024. 63rd
  • 謝琳, 破入正行, 張一鼎, 藤永雅之, 峯岸克行, 大久保崇之, 永津弘太郎, 下川卓志, 足助一真, 張明栄. mGluR1陽性ヒト癌に対する211At-AITMによる標的アイソトープ治療の検証. 核医学(Web). 2023. 60. Supplement
  • 加川雄介, 野口拓也, 下川卓志. “重イオンビーム”どうでしょう?. 生物工学会誌. 2023. 101. 7
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Patents (3)：
Education (3)：
  • 1996 - 2000 The University of Tokyo Graduate School of Medicine Department of Radiological Health
  • 1994 - 1996 Toho University Graduate School of Science
  • 1990 - 1994 Toho University Faculty of Science Department of Biomolecular Science
Professional career (2)：
  • Dr. of Medical Science (The University of Tokyo)
  • (BLANK) (Toho University)
Work history (9)：
  • 2021/04 - 現在 National Institutes for Quantum and Radiological Science and Technology
  • 2016/04 - 2021/03 National Institutes for Quantum and Radiological Science and Technology National Institute of Radiological Sciences
  • 2011 - 2016/03 National Institute of Radiological Sciences
  • 2004 - 2011 Karolinska Institutet
  • 2004 - 2011 Department of Biosciences and Nutrition, Center for Biosciences, Karolinska Institutet, Sweden
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Committee career (3)：
  • 2022/06 - 現在 PTCOG Biology sub-committee
  • 2021/09 - 現在 一般社団法人 量子医科学会 学術行事委員会 委員
  • 2016/04 - 2018/03 一般社団法人 日本放射線影響学会 学術評議委員
Association Membership(s) (1)：
日本量子医科学会
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