Rchr
J-GLOBAL ID：200901095778601892   Update date: May. 20, 2024

Mitsuru Okuwaki

オクワキ ミツル | Mitsuru Okuwaki
Affiliation and department：
Kitasato University School of Pharmaceutical Sciences

About Kitasato University School of Pharmaceutical Sciences


Homepage URL  (1)： https://www.kitasato-u.ac.jp/pharm/
Research field  (4)： Molecular biology ,  Cell biology ,  Virology ,  Genetics
Research theme for competitive and other funds  (15)：
  • 2017 - 2020 Regulation of gene expression by histone chaperones
  • 2017 - 2020 Oncogenic mechanisms by nucleoporin
  • 2014 - 2017 A novel mechanism of cell growth regulation by the intrinsically disordered protein, NPM1
  • 2013 - 2016 Dynamic regulation of chromatin by histone chaperone
  • 2009 - 2014 Regulatory functions of IDPs in the nuclear network of the genetic information systems
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Papers (65)：
  • Hitomi Okamoto, Yoichi Tanaka, Yoshio Shibagaki, Satoshi Kuronuma, Yusuke Miyatani, Satoko Umeda, Emi Mishiro-Sato, Osamu Takeuchi, Seisuke Hattori, Taku Kobayashi, et al. Measurement of the intracellular active metabolites of thiopurine drugs to evaluate the enzymatic activity of nudix hydrolase 15 in human blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024. 1234. 123993-123993
  • Mitsuru Okuwaki, Shin-Ichiro Ozawa, Shuhei Ebine, Motoki Juichi, Tadanobu Umeki, Kazuki Niioka, Taiyo Kikuchi, Nobutada Tanaka. The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets. Journal of biochemistry. 2023
  • Sadik Cigdem, Shoko Saito, Daiki Nishikata, Kyosuke Nagata, Mitsuru Okuwaki. SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 10. 830-837
  • Hiroko Hirawake-Mogi, Nguyen Thi Thanh Nhan, Mitsuru Okuwaki. G-patch domain-containing protein 4 localizes to both the nucleoli and Cajal bodies and regulates cell growth and nucleolar structure. Biochemical and Biophysical Research Communications. 2021. 559. 99-105
  • Mitsuru Okuwaki, Ai Saotome-Nakamura, Masashi Yoshimura, Shoko Saito, Hiroko Hirawake-Mogi, Takeshi Sekiya, Kyosuke Nagata. RNA-recognition motifs and glycine and arginine-rich region cooperatively regulate the nucleolar localization of nucleolin. The Journal of Biochemistry. 2021. 169. 1. 87-100
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MISC (16)：
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Books (10)：
  • 薬と生命を学ぶ人のための基礎生化学
    化学同人 2023 ISBN:9784759821666
  • 実験医学増刊「相分離 メカニズムと疾患」
    2021
  • 目的別で選べるタンパク質発現プロトコール
    2010
  • タンパク質-RNA複合体による核小体形成機構
    2005
  • ヒストンシャペロンの動的役割分担.
    2005
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Lectures and oral presentations  (21)：
  • ヒト血液サンプルにおけるNUDT15酵素活性の測定
    (日本薬学会第143年会 2023)
  • 微生物由来抗結核剤 calpinactam の標的分子の解析
    (日本薬学会第143年会 2023)
  • Mechanism of transcriptional activation regulation of C/EBPa in leukemia associated with the translocated fusion gene product DEK-NUP214
    (2022)
  • ALS関連遺伝子のリピート配列伸長が核小体構造に与える影響の検討
    (第44回日本分子生物学会年会 2021)
  • 翻訳開始位置変動がNPM1の多量体形成能と液-液相分離能へ与える影響
    (第44回日本分子生物学会年会 2021)
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Education (2)：
  • - 1999 Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering
  • - 1994 Tokyo Institute of Technology Faculty of Life Science and Engineering
Work history (6)：
  • 2018/04 - 現在 Kitasato University School of Pharmacy Professor
  • 2007/12 - 2018/03 University of Tsukuba University of Tsukuba Associate Professor
  • 2004/04/01 - 2007/11/30 University of Tsukuba
  • 2003/05/16 - 2004/03/31 University of Tsukuba Institute of Basic Medical Sciences
  • 2002/04/01 - 2003/05/15 Cancer Research UK Research Fellow
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Association Membership(s) (3)：
日本薬学会 ,  The Molecular Biology Society of Japan ,  THE JAPANESE BIOCHEMICAL SOCIETY
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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