Research field (4):
Molecular biology
, Cell biology
, Virology
, Genetics
Research theme for competitive and other funds (15):
2017 - 2020 Regulation of gene expression by histone chaperones
2017 - 2020 Oncogenic mechanisms by nucleoporin
2014 - 2017 A novel mechanism of cell growth regulation by the intrinsically disordered protein, NPM1
2013 - 2016 Dynamic regulation of chromatin by histone chaperone
2009 - 2014 Regulatory functions of IDPs in the nuclear network of the genetic information systems
2010 - 2012 A novel function of RNA in the regulation of chromatin structure
2007 - 2011 RNA-タンパク質複合体による細胞核機能・構造制御
2008 - 2009 クロマチンダイナミクス制御因子の実体解明とその協調的機能発現機構
2005 - 2009 The mechanism for cell onocogenesis by chromosome-translocated chromatin remodeling factors
2007 - 2008 核小体形成ダイナミクスの分子解剖
2006 - 2007 クロマチンの構造・機能を制御する酸性分子シャペロン
2005 - 2006 クロマチン構造制御から迫る核小体形成機構
2004 - 2006 核小体クロマチンの機能制御機構
2005 - 2005 酸性分子シャペロンによるクロマチン機能制御
2000 - 2001 真核細胞におけるクロマチン構造を介した遺伝子発現制御機構の解析
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Papers (65):
Hitomi Okamoto, Yoichi Tanaka, Yoshio Shibagaki, Satoshi Kuronuma, Yusuke Miyatani, Satoko Umeda, Emi Mishiro-Sato, Osamu Takeuchi, Seisuke Hattori, Taku Kobayashi, et al. Measurement of the intracellular active metabolites of thiopurine drugs to evaluate the enzymatic activity of nudix hydrolase 15 in human blood samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2024. 1234. 123993-123993
Mitsuru Okuwaki, Shin-Ichiro Ozawa, Shuhei Ebine, Motoki Juichi, Tadanobu Umeki, Kazuki Niioka, Taiyo Kikuchi, Nobutada Tanaka. The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets. Journal of biochemistry. 2023
Sadik Cigdem, Shoko Saito, Daiki Nishikata, Kyosuke Nagata, Mitsuru Okuwaki. SET-NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene. Genes to cells : devoted to molecular & cellular mechanisms. 2021. 26. 10. 830-837
Hiroko Hirawake-Mogi, Nguyen Thi Thanh Nhan, Mitsuru Okuwaki. G-patch domain-containing protein 4 localizes to both the nucleoli and Cajal bodies and regulates cell growth and nucleolar structure. Biochemical and Biophysical Research Communications. 2021. 559. 99-105
Mitsuru Okuwaki, Ai Saotome-Nakamura, Masashi Yoshimura, Shoko Saito, Hiroko Hirawake-Mogi, Takeshi Sekiya, Kyosuke Nagata. RNA-recognition motifs and glycine and arginine-rich region cooperatively regulate the nucleolar localization of nucleolin. The Journal of Biochemistry. 2021. 169. 1. 87-100