2019 - 2022 The clarification of bone formation and absorption mechanism in the bone marrow microenvironment
2019 - 2022 Examination for the effect of chewing on cognitive function and comprehensive search for biomarkers for early diagnosis of dementia
2019 - 2022 Bone marrow microenvironment of MRONJ and application of Escherichia coli derived BMP-2
2018 - 2021 Understanding of molecular mechanisms of tooth development using iPS interference and application to tooth regeneration techniques
2018 - 2021 The functional analysis of WISP1 gene aimed at the prevention of osteoarthritis
2017 - 2021 Molecular understanding of the accumulation of mesenchymal stem cells in vivo by photo-manipulation techniques and its application to bone-related diseases
2018 - 2020 Elucidation of undifferentiated maintaining mechanism of stem cell towards the control of stem cell aging
2017 - 2020 Understanding of periodontal disease and peri-implantitis with stem cell disfunction
2017 - 2020 Application of artificial periosteum containing BMP-2 to the treatment of refractory bone disease and bone nonunion.
2016 - 2020 Evaluation of upper airway size using Magnet Resonance Imaging
2016 - 2019 The development of bone regeneration therapy based on the clarification of mechanism of BMP-2 induced bone formation and resorption
2016 - 2019 A comprehensive search applying 16SrRNA sequencing analysis to investigate oral and intestinal flora causing malnutrition in the elderly
2016 - 2019 Bone regenerative therapy using Escherichia coli-derived rhBMP-2 adsorbed in beta-TCP.
2015 - 2019 Guided control of keratinized epithelial mucosa as a next generation periodontal soft tissue regeneration
2016 - 2018 Identification of risk factor of CKD and pathogenic bacteria of infectious complications in dialysis
2016 - 2018 Analysis of the initial mineralization in secondary ossification center by the Life Science and Material Science viewpoints
2016 - 2018 Examine the effect of HMGB1 on bone marrow derived mesenchymal stem cell
2016 - 2018 Chronic muscle pain pathophysiology from the viewpoint of mitochondria dysfunction
2016 - 2018 Search of master regulator of odontoblastogenesis using iPS interference
2015 - 2018 Elucidation of the biological pathology of peri-implantitis and development of immunological therapy.
2014 - 2018 Development of tooth regeneration technology based on the clarification of mechanism of tooth development.
2015 - 2017 Identification of master genes for regulating developmental time in regenerated organs
2015 - 2017 Maintenance of undifferentiated state of mesenchymal stem cells using amino acids for the regulation of stem cell aging
2015 - 2017 Development of prevention and repair of degenerative joint disorders with fluocinolone acetonide (FA).
2014 - 2017 Development of tissue regeneration therapy using host stem cell homing
2014 - 2017 Comprehensive analysis of bacterial flora around dental implants by Next Generation Sequencer and development of antibacterial therapy.
2014 - 2016 Therapeutic effect of human dental pulp stem cell on Experimental autoimmune encephalomyelitis.
2013 - 2016 Development of technologies for next-generation regenerative therapies
2013 - 2016 The mechanism identification of environmental selective bone induction/suppression of BMP-2
2013 - 2016 Do severe sleep bruxism subjects have the cardiovascular risk due to sleep hypertension?
2013 - 2015 The identification and functional analysis of attached gingiva related gene and protein
2013 - 2015 Development of production technique of tissue derived stem cell using novel reprogramming system.
2012 - 2015 Investigation of biological pathogenesis and development of prevention diagnosis protocol of peri-implantitis.
2011 - 2015 A long-term cohort study of resin bonded/conventional fixed partial prosthesis and development of a next-generation clinical data recording system
2011 - 2015 Verification study of sleep bruxism pathogenesis focused on the serotonin nerve activities as neuromodulator
2012 - 2014 Study of the effect in perioperative oral management
2012 - 2014 The identification of maintenance mechanism of mesenchymal stem cells based on the niche concept of SCAP.
2012 - 2014 A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.
2010 - 2014 The technological development of bioengineered regenerated tooth, based on the mechanism of development
2010 - 2014 Development of a new treatment for trigeminal neuron sensitization
2010 - 2014 A multifunctional implant which can achieve the site-specific tissue regeneration
2010 - 2013 高脂血症治療薬;スタチンを応用した象牙質形成促進作用を持つ新規覆髄材の開発
2011 - 2013 Functional regeneration of the oral cavity marginal muscles by cybernics approach
2011 - 2012 Development of neuro-regeneration with Botulinum toxin
2011 - 2012 Development of a technic to generate somatic stem cells using a newly reprogramming method.
2011 - 2012 Investigation of the mechanisms involving BMP-2-induced inhibition of bone formation or niche formation at the bone marrow microenvironment.
2006 - 2009 Basic mechanisms of nociceptive sensitization of first order sensory neuron in trigeminal neuralgia and treatment development
2007 - 2008 The local anti-cytokine therapy for severe osteoarthritis of temporomandibular joint with soluble TNF receptor type II
2007 - 2008 咬合感覚異常症患者における末梢および中枢知覚神経活動の亢進と治療法開発
2007 - 2008 付着歯肉の分化に関連した特異的遺伝子・蛋白の同定とその機能解析
2006 - 2008 Dentin regeneration by dental pulp stem cell, dental epithelium and dental mesenchyme
2005 - 2008 Establishment of Information Basis for Tooth Regeneration
2005 - 2008 Newly developed bio-active implant by minute control of apatite coating layer.
2006 - 2007 結合組織成長因子(CCN2/CTGF)を用いた顎顔面領域の三次元軟骨再生
2006 - 2007 Genetic analysis of monoamine transporter and relation to the frequency of the nocturnal bruxism.
2006 - 2007 Bone regeneration with degradable hydrogels and genetically modified, recombinant human BMP-2 with two additional repeats of the heparin-binding domain.
2006 - 2007 アドレナリンレプターの遺伝子多型からみた慢性筋痛の病態解明と症型分類
2005 - 2007 Synthesis of a novel functional monomer and development of an adhesive system appropriate to laser-irradiated dental tissues
2005 - 2007 Development of chair-side assay system for ongoing bone loss with peri-implant sulcus fluids
2006 - 2006 オゾン照射によるエルビウムヤグレーザー照射象牙質の脆弱層強化
2005 - 2006 The practice of anti-cytokine treatment for temporomandibular joint osteoarthritis
2004 - 2006 Assessment of gene transfer method for induction of osseo integration on dental implant
2004 - 2005 Development of functional Ti implants with release of growth factors
2004 - 2005 Establishment of an autologous cell transplantion method using mesenchymal stem cells for alveolus bone regeneration.
2004 - 2005 Epidemiological and clinical research by a miniature bruxism detection device - Verify the prevalence, proportionate contribution for TMD and efficacy of oral appliance therapy -
2003 - 2005 Cloning, Expression and Identification of Specific Genes related Osseointegration to Titanium.
2002 - 2005 Gene Therapy for Periodontal Diseases -Regulation of host response by local gene delivery-
2003 - 2004 Development of chair-side assay system for ongoing bone loss with peri-implant sulcus fluids
2003 - 2004 The trial of treatment for temporomandibular joint osteoarthritis with soluble tumor necrosis factor receptor
2003 - 2004 口腔インプラントの骨結合獲得難易度を予測する生物学的診断法の開発
2002 - 2004 Establishment of a autologous cell transplantion method using mesenchymal stem cells for perio-dontal tissue and alveolus bone regeneration.
2002 - 2003 Molecular mechanism of temporomandibular joint osteoarthritis and gene therapy for degraded, cartilage
2002 - 2003 Development of the methods for application of the factors that biologically accelerate reparative dentin formation
2001 - 2002 Risk assessment of peri-inplantitis patients with chair-side MMP-8 assay system
2001 - 2002 Responses of Hypothalamic-Pituitary-Adrenal axis to cold pressor stimulation
1995 - 1996 Osteoarthritis of the TMJ and Mechanical Stress
1993 - 1993 片側噛みしめ時におけるヒト顎関節関節円板動態
1992 - 1992 成人顎関節の骨改造能に関する研究
1991 - 1991 顎関節円板,顎関節軟骨の耐圧縮特性に関する生物力学的ならびに組織学的研究
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Papers (262)：
Aung Ye Mun, Kentaro Akiyama, Ziyi Wang, Jiewen Zhang, Wakana Kitagawa, Teisaku Kohno, Ryuji Tagashira, Kei Ishibashi, Naoya Matsunaga, Tingling Zou, et al. Macrophages modulate mesenchymal stem cell function via tumor necrosis factor alpha in tooth extraction model. JBMR plus. 2024. 8. 8. ziae085
Emi Hatano, Nahid Akhter, Risa Anada, Mitsuaki Ono, Toshitaka Oohashi, Takuo Kuboki, Hiroshi Kamioka, Masahiro Okada, Takuya Matsumoto, Emilio Satoshi Hara. The cell membrane as biofunctional material for accelerated bone repair. Acta biomaterialia. 2024
Kana Tokumoto, Takuya Mino, Ikue Tosa, Ko Omori, Michiyo Yamamoto, Kazuki Takaoka, Kenji Maekawa, Takuo Kuboki, Hiromitsu Kishimoto. Long-term follow-up of a patient with Parkinson's disease under nursing care after replacement of fixed implant-supported prostheses with an implant overdenture: a case report. International journal of implant dentistry. 2024. 10. 1. 37-37
Kenji Fueki, Yuta Manabe, Keiichi Sasaki, Katsuhiko Kimoto, Mamoru Hashimoto, Takayuki Ueda, Kumiko Utsumi, Tomohisa Ishikawa, Kazuyoshi Baba, Manabu Ikeda, et al. Medical-dental collaboration on an exploratory research project on the correlation between cognitive and oral function: The ECCO project. Journal of prosthodontic research. 2024
Anh Tuan Dang, Mitsuaki Ono, Ziyi Wang, Ikue Tosa, Emilio Satoshi Hara, Akihiro Mikai, Wakana Kitagawa, Tomoko Yonezawa, Takuo Kuboki, Toshitaka Oohashi. Local E-rhBMP-2/β-TCP Application Rescues Osteocyte Dendritic Integrity and Reduces Microstructural Damage in Alveolar Bone Post-Extraction in MRONJ-like Mouse Model. International Journal of Molecular Sciences. 2024. 25. 12. 6648-6648
坂本和基, 大野彩, 黒崎陽子, 三野卓哉, 中川晋輔, 下村侑司, 小山絵理, 樋口隆晴, 大森江, 徳本佳奈, et al. Association of prosthodontic treatment with dietary diversity and nutritional intake in older outpatients. 日本補綴歯科学会誌(Web). 2024. 16
坂本和基, 大野彩, 大野彩, 三野卓哉, 三野卓哉, 黒崎陽子, 黒崎陽子, 中川晋輔, 下村侑司, 大森江, et al. Association between prosthodontic treatment methods and food intake status in elderly patients after prosthodontic treatment. 日本補綴歯科学会中国・四国支部学術大会プログラム・抄録集(Web). 2023. 2023
LOC Hoangdinh, LOC Hoangdinh, 青山絵理子, 日浅未来, 表弘志, 久保田聡, 窪木拓男, 滝川正春. S-adenosylmethionine promotes chondrocyte differentiation via polyamine synthesis and gene expression of growth factors. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
DO THUY Hang, DO THUY Hang, 大野光昭, 大野光昭, 小盛大志, 小盛大志, 北川若奈, 北川若奈, 窪木拓男, 窪木拓男, et al. Comparative in silico analysis of keratinized and non-keratinized gingiva by reanalysis of previously published human single-cell RNA-seq data. 日本補綴歯科学会誌(Web). 2023. 15
北川若奈, 北川若奈, 大野充昭, 大野充昭, 土佐郁恵, 石橋啓, 石橋啓, 窪木拓男, 窪木拓男, 大橋俊孝. Mechanism of delayed bone wound healing in mice long bone due to bone marrow aging using scRNA-seq. 日本補綴歯科学会誌(Web). 2023. 15
