Sakata Nobuo

Research field (4)： Experimental pathology , Clinical pharmacy , Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (6)：分子病理学 , 分子生物学 , 転写因子 , Molecular Pathology , Molecular Biology , Transcription Factor

Research theme for competitive and other funds (2)：

2013 - 2014 Smad-mediated spliceosome assembly and alternative splicing
2002 - 2004 EXPRESSION ANALYSIS OF TRANSCRIPTION FACTOR, ATBF1 AND ZFH4 IN NORMAL DEVELOPING RAT BRAIN

Papers (31)：

Eriko Nakamura, Kenji Hata, Yoshifumi Takahata, Hiroshi Kurosaka, Makoto Abe, Takaya Abe, Miho Kihara, Toshihisa Komori, Sachi Kobayashi, Tomohiko Murakami, et al. Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice. Communications Biology. 2021. 4. 1
Naoko Nakano, Nobuo Sakata, Yuki Katsu, Daiki Nochise, Erika Sato, Yuta Takahashi, Saori Yamaguchi, Yoko Haga, Souichi Ikeno, Mitsuyoshi Motizuki, et al. Dissociation of the AhR/ARNT complex by TGF-β/Smad signaling represses CYP1A1 gene expression and inhibits benze[a]pyrene-mediated cytotoxicity. Journal of Biological Chemistry. 2020. 295. 27. 9033-9051
Souichi Ikeno, Naoko Nakano, Keigo Sano, Takashi Minowa, Wataru Sato, Ryosuke Akatsu, Nobuo Sakata, Nobutaka Hanagata, Makiko Fujii, Fumiko Itoh, et al. PDZK1-interacting protein 1 (PDZK1IP1) traps Smad4 protein and suppresses transforming growth factor- (TGF-) signaling. Journal of Biological Chemistry. 2019. 294. 13. 4966-4980
Naoko Nakano, Yuki Tsuchiya, Kenro Kako, Kenryu Umezaki, Keigo Sano, Souichi Ikeno, Eri Otsuka, Masashi Shigeta, Ai Nakagawa, Nobuo Sakata, et al. TMED10 Protein Interferes with Transforming Growth Factor (TGF)-beta Signaling by Disrupting TGF-beta Receptor Complex Formation. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 10. 4099-4112
Makoto Kawaguchi, Noboru Hara, Vladimir Bilim, Hiroshi Koike, Mituko Suzuki, Tae-Sun Kim, Nan Gao, Yu Dong, Sheng Zhang, Yuji Fujinawa, et al. A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. BMC cancer. 2016. 16. 1. 805-805

ｍore...

MISC (4)：

野上重治, 石井陽子, 川口誠, 坂田宣夫, 尾矢剛志, 高川清, 金森昌彦, 木村友厚, 笹原正清. 発達ラット脳におけるATBF1及びZFH-4転写因子の発現解析. 日本整形外科学会雑誌. 2003. 77. 8. S1173-S1173
石井陽子, 川口誠, 野上重治, 高川清, 尾矢剛志, 井戸章雄, 三浦裕, 橋本知子[玉置], 坂田宣夫, Zhao Yingulan, et al. ATBF1(AT-motif Binding Factor 1)のラット脳における発現解析. 神経化学. 2001. 40. 2-3. 366-366
川口誠, 三浦裕, 井戸章雄, 森永伴法, 坂田宣夫, 尾矢剛志, 橋本知子[玉置], 笹原正清, 小泉富美朝, 玉置大器. ATBF1(AT-motif binding factor 1)におけるDNA/RNA-dependent ATPase活性の検討. 日本病理学会会誌. 2001. 90. 1. 205-205
石井陽子, 川口誠, 井戸章雄, 三浦裕, 橋本知子[玉置], 田村周, 高川清, 尾矢剛志, 坂田宣夫, Zhao Yingluan. ラット発達期脳におけるATBF1(AT-motief binding factor 1)発現の解析. 日本病理学会会誌. 2001. 90. 1. 205-205

Lectures and oral presentations (5)：

Transcriptional Repression Mechanisms of TGF-β Signaling and ATBF1 on the AFP Promoter
(Joint International Symposium on TGF-β Family and Cancer “Signal Network in Tumor Microenvironment” 2015)
ZFHX Family of Transcriptional Factors
(The Eighth NIBB-EMBL Joint Meeting, Evolution: Genomes, Cell Types and Shapes, p57, P13 (2008) 2008)
エンダイイン-クロモフォアを含む蛋白性制癌抗生物質
(日本放線菌学会第8回講演会 1993)
Bleomycin: Structure-Activity Relationship in Semisynthetic Bleomycin
(Horizons on Antibiotic Resarch: Proceedings of the Symposium Dedicated to the Late Professor Hamao Umezawa, Eds, B. D. Davis et. al., pp88-101, Japan Antibiotics Research Association 1987)
Studies on the Structure of Transfer RNA Genes
(Indian J. Biochem. Biophys., 18, 15 (1981): Proceedings of Annual Meeting and 2nd Congress of the Federation of Asian and Oceanian Biochemists 1980)

Works (5)：

Study of TGF-beta signaling
2010 - 現在
ZFHXファミリー転写因子の研究
1994 - 現在
Study of Transcription Factor, ATBF1 and ZFH4
1994 - 現在
Chromoprotein群制がん抗生物質の研究
1985 - 1993
Study of Cromoprotein Antitumor Antibiotics
1985 - 1993

Education (2)：

1978 - 1980 Showa Pharmaceutical University Graduate School Research Division in Pharmaceutical Sciences
1974 - 1978 Showa Pharmaceutical University Faculty of Pharmaceutical Sciences Department of Bio-Pharmacy

Professional career (2)：

PhD (Chiba University)
MS (Showa Pharmaceutical University)

Work history (4)：

1996/04 - 2020/03 昭和薬科大学専任講師
1980/04 - 1996/03 Showa Pharmaceutical University
1994/07 - 1995/06 カルガリー大学医学部博士研究員
1978/04 - 1980/03 国立がんセンター研究所研修生

Association Membership(s) (3)：

THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN

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